Cutaneous zygomycosis - Necrotising fascitis due to Saksena vasiformis

Padmaja, IJ; Ramani, TV; Kalyani, S

doi:10.4103/0255-0857.19898

Cited by 26 publications

(12 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…vasiformis infections occur most often after trauma (Table 2), including motor vehicle accidents (4,81,100,162), insect or spider bites, scorpion stings, bird pecks, tattoos, burns, and nosocomial exposures or health care-associated exposure via intramuscular injections, needle sticks, and vascular catheter and surgery sites (29,58,64,110,134,185,230,240,241,250,319,334,343). Similar to the case with Apophysomyces elegans, soil contamination of the trauma site is the probable cause of S. vasiformis infection in most patients (279).…”

Section: Saksenaea Vasiformis Complexmentioning

confidence: 99%

“…Necrotizing fasciitis or cellulitis (29,37,51,58,64,107,162,171,185,230,241,253,319,366) extending rapidly to neighboring tissues (29,37,51,58,64,107,162,185,253,319,366) is the most common characteristic of soft tissue S. vasiformis infection. Abscess formation with fat necrosis has also been described (266,326,366), with histological evidence of satellite lesions in one of these cases (366).…”

Section: Saksenaea Vasiformis Complexmentioning

confidence: 99%

See 1 more Smart Citation

Mucormycosis Caused by Unusual Mucormycetes, Non-Rhizopus, -Mucor, and -Lichtheimia Species

2011

View full text Add to dashboard Cite

SUMMARY Rhizopus , Mucor , and Lichtheimia (formerly Absidia ) species are the most common members of the order Mucorales that cause mucormycosis, accounting for 70 to 80% of all cases. In contrast, Cunninghamella , Apophysomyces , Saksenaea , Rhizomucor , Cokeromyces , Actinomucor , and Syncephalastrum species individually are responsible for fewer than 1 to 5% of reported cases of mucormycosis. In this review, we provide an overview of the epidemiology, clinical manifestations, diagnosis of, treatment of, and prognosis for unusual Mucormycetes infections (non- Rhizopus , - Mucor , and - Lichtheimia species). The infections caused by these less frequent members of the order Mucorales frequently differ in their epidemiology, geographic distribution, and disease manifestations. Cunninghamella bertholletiae and Rhizomucor pusillus affect primarily immunocompromised hosts, mostly resulting from spore inhalation, causing pulmonary and disseminated infections with high mortality rates. R. pusillus infections are nosocomial or health care related in a large proportion of cases. While Apophysomyces elegans and Saksenaea vasiformis are occasionally responsible for infections in immunocompromised individuals, most cases are encountered in immunocompetent individuals as a result of trauma, leading to soft tissue infections with relatively low mortality rates. Increased knowledge of the epidemiology and clinical presentations of these unusual Mucormycetes infections may improve early diagnosis and treatment.

show abstract

Section: Saksenaea Vasiformis Complexmentioning

confidence: 99%

Section: Saksenaea Vasiformis Complexmentioning

confidence: 99%

Mucormycosis Caused by Unusual Mucormycetes, Non-Rhizopus, -Mucor, and -Lichtheimia Species

2011

View full text Add to dashboard Cite

show abstract

“…Among the 22 cases of cutaneous infection, one occurred after insect bites (5) and one after a spider bite (10). Most cases of human disease occur in warmer, tropical and subtropical climates and have been found in the United States, Australia, New Zealand, Colombia, Ecuador, French Guiana, Israel, Thailand, Spain, India, and Iraq (6,12,17,18). The case in this report is the 36th reported case of S. vasiformis infection and the first reported case contracted in Tunisia.…”

Section: Mucormycoses Are Infections Caused By Zygomycetes and Mostlymentioning

confidence: 69%

“…Up to now, 35 cases of S. vasiformis infection have been reported (1,3,6,12,17,18). Twenty of the 28 patients reported in the review of Vega et al were immunocompetent (18).…”

Section: Mucormycoses Are Infections Caused By Zygomycetes and Mostlymentioning

confidence: 99%

Molecular Diagnosis of Saksenaea vasiformis Cutaneous Infection after Scorpion Sting in an Immunocompetent Adolescent

et al. 2008

View full text Add to dashboard Cite

We report the first case of cutaneous mucormycosis after a scorpion sting in Tunisia. Histopathology showed broad aseptate hyphae suggestive of a Zygomycete. Saksenaea vasiformis was identified by PCR amplification and sequencing of the fungal DNA on a cutaneous biopsy. Successful treatment was obtained by surgery and liposomal amphotericin B. CASE REPORTA previously healthy 14-year-old patient was admitted to Robert Debré hospital (Paris) with a left calf lesion following a scorpion sting in Tunisia 10 days before. At that time, he had been hospitalized for 4 days in an intensive care unit for acute renal failure and pulmonary edema induced by the scorpion venom. When he came back to France, the lesion due to the scorpion sting failed to heal.On the day of admission, the patient had a limping gait. Physical examination of the left calf revealed a painful, indurated, erythematous, 5-cm lesion. Ultrasonic tomography revealed a diffuse, soft tissue swelling. The white blood cell count was 14.1 ϫ 10 9 /liter with 71% neutrophils, the platelet count was 395 ϫ 10 9 /liter, and the C-reactive protein level was less than 10 mg/liter. The patient was started on antibacterial therapy with cefotaxime and fosfomycin according to our local guidelines for antibiotic treatment (9).On day 5, the lesion grew to a 10-cm area of swelling and induration, with a central area of black blisters. No sample was taken at this stage. The patient had a fever (38.7°C) and experienced severe pain. The white blood cell count was 18.9 ϫ 10 9 /liter with 80% neutrophils, and the C-reactive protein level was 52 mg/liter. Three blood cultures performed between day 1 and day 5 were sterile. A second ultrasonic tomography showed an extension within subcutaneous tissues, with collection of fluids. Because of the increasing area of the wound, vancomycin and metronidazole were added to the treatment regimen.On day 7, the patient required local debridement to remove devitalized tissues, including muscles and fascia. A 7-cm incision was made to evacuate the necrotizing tissue. A piece of debrided tissue was submitted for microbiological and histopathological examination. On day 12, histological analysis showed many areas of necrosis and nonspecific inflammation. Within the necrotic areas, branched, broad, nonseptate fungal hyphae suggestive of Zygomycetes were found. The material was inoculated onto routine bacteriological media and Sabouraud dextrose agar. On the Sabouraud dextrose agar, there were few colonies of filamentous fungi, with no evidence of sporulation, and the loss of viability of the isolate, possibly due to growth conditions, precluded subcultures on specific media (11), impaired any further mycological identification. All other cultures on solid media were negative for bacteria. The cutaneous biopsy, kept frozen at Ϫ80°C, was then sent to the National Reference Center for Mycoses and Antifungals, Pasteur Institute, for molecular studies. Tissues were ground, and DNA extraction was performed as previously described (16). Direct examinat...

show abstract

“…Primary cutaneous zygomycosis due to Saksenaea vasiformis has subsequently been reported from Chandigarh in 1977[9] and recently in 2006 by Padmaja et al . [10] from Vishakhapatnam.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous zygomycosis due to Saksenaea vasiformis in an immunocompetent host

Baradkar

Kumar

2009

Indian J Dermatol

View full text Add to dashboard Cite

Saksenaea vasiformis is an emerging zygomycete species, most often associated with cutaneous, subcutaneous and rhino- orbito-cerebral infections. Herein, we report a case of cutaneous zygomycosis of face caused by Saksenaea vasiformis in a 54-year-old immunocompetent female. The diagnosis was carried out by microscopy using KOH mount, Gram staining, Gomori's methenamine silver staining, hemotoxylin and eosin staining and culture on Sabouraud's Dextrose agar without actidione. Slide cultures were put up on Czapek Dox agar, which showed typical flask-shaped sporangium with rhizoids. The patient was treated successfully with intravenous amphotericin B.

show abstract

Cutaneous zygomycosis - Necrotising fascitis due to Saksena vasiformis

Cited by 26 publications

References 7 publications

Mucormycosis Caused by Unusual Mucormycetes, Non-Rhizopus, -Mucor, and -Lichtheimia Species

Mucormycosis Caused by Unusual Mucormycetes, Non-Rhizopus, -Mucor, and -Lichtheimia Species

Molecular Diagnosis of Saksenaea vasiformis Cutaneous Infection after Scorpion Sting in an Immunocompetent Adolescent

Cutaneous zygomycosis due to Saksenaea vasiformis in an immunocompetent host

Contact Info

Product

Resources

About