Saksenaea vasiformis is an emerging human pathogen, most often associated with cutaneous or subcutaneous lesions following trauma. This is the report of a case of subcutaneous zygomycosis from which Saksenaea vasiformis was isolated on culture. As the patient developed acute interstitial nephritis, amphotericin B could not be administered in full dose. Surgical debridement was carried out, but the patient deteriorated gradually and died. To the best of our knowledge, this is the first reported case of Zygomycosis due to Saksenaea vasiformis from Visakhapatnam.

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Hydrops Fetalis is a Greek term that describes pathological fluid accumulation in fetal soft tissues and serous cavities, peritoneal, pleural, pericardial, scalp and body wall. Hydrops Fetalis is considered as a prenatal form of cardiac failure. It is broadly divided into two groups-Immune Hydrops Fetalis (IHF) and Non-Immune Hydrops Fetalis (NIHF). In previous years most of the Immune Hydrops Fetalis is caused by Erythroblastosis Fetalis secondary to Rh Iso-immunization with presence of maternal circulating red cell antibodies. IHF has now decreased with passive maternal immunization markedly up to 20% (1990). Recently, Non-immune Hydrops Fetalis (NIHF) is relatively more common and accounts for 90% of Hydrops Fetalis. NIHF is also defined as universal edema unassociated with Erythroblastosis Fetalis. It can be caused by wide variety of factors including fetal disorders (Chromosomal abnormalities, Congenital malformation & Twinning), Cardiovascular, metabolic causes, maternal diseases (Diabetes, Hypothyroidism, Anemias), placental and cord abnormalities and infectious pathogens acquired in-utero (Cytomegalovirus). The incidence of NIHF is estimated at 1 in 3000 pregnancies. The aetiology of Hydrops Foetalis is based on the presence or absence of anaemia leading to heart failure and generalized oedema in the foetus and neonate. In approximately 1/4 of all cases, the cause is not determined.