In minimal quantity lubrication (MQL) machining of aluminum alloys, since they have highly adhesive characteristics, more effective lubrication is necessary. This study therefore proposes that oxygen-including compounds, such as esters, alcohols and acids, are considered to be a potential MQL lubricant. The experimental investigations have shown the cutting performance of those oxygen-including compounds has greatly been influenced by their chemical structures. Some of them have been able to provide the successful cutting performance as a MQL cutting fluid and, in particular, specific alcohols have demonstrated the superior anti-adhesive characteristics in MQL end milling.