CX3CR1(+) B Cells Show Immune Suppressor Properties

Wu, Zhiqiang

doi:10.1074/jbc.m114.569459

Cited by 14 publications

(6 citation statements)

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“…It has been reported that CX 3 CR1 + B cells are increased in people with food allergies ( 16 ). CX 3 CR1 + B cells have transforming growth factor (TGF)-β and integrin αvβ6 that can suppress CD4 + T cell activity.…”

Section: Bone Marrow and Immune Systemmentioning

confidence: 99%

“…CX 3 CR1 + B cells have transforming growth factor (TGF)-β and integrin αvβ6 that can suppress CD4 + T cell activity. Neonatal regulatory B lymphocytes (nBreg cells) can react with protein F of respiratory syncytial virus to upregulate CX 3 CR1 which can then react with glycoprotein G, resulting in viral infection ( 16 ). These interactions could make nBreg cells induce IL-10 production, resulting in weakened cytokine production of Th1 cells ( 17 ).…”

Section: Bone Marrow and Immune Systemmentioning

confidence: 99%

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Tissue-specific Role of CX₃CR1 Expressing Immune Cells and Their Relationships with Human Disease

et al. 2018

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Chemokine (C-X3-C motif) ligand 1 (CX3CL1, also known as fractalkine) and its receptor chemokine (C-X3-C motif) receptor 1 (CX3CR1) are widely expressed in immune cells and non-immune cells throughout organisms. However, their expression is mostly cell type-specific in each tissue. CX3CR1 expression can be found in monocytes, macrophages, dendritic cells, T cells, and natural killer (NK) cells. Interaction between CX3CL1 and CX3CR1 can mediate chemotaxis of immune cells according to concentration gradient of ligands. CX3CR1 expressing immune cells have a main role in either pro-inflammatory or anti-inflammatory response depending on environmental condition. In a given tissue such as bone marrow, brain, lung, liver, gut, and cancer, CX3CR1 expressing cells can maintain tissue homeostasis. Under pathologic conditions, however, CX3CR1 expressing cells can play a critical role in disease pathogenesis. Here, we discuss recent progresses of CX3CL1/CX3CR1 in major tissues and their relationships with human diseases.

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Section: Bone Marrow and Immune Systemmentioning

confidence: 99%

Section: Bone Marrow and Immune Systemmentioning

confidence: 99%

Tissue-specific Role of CX₃CR1 Expressing Immune Cells and Their Relationships with Human Disease

et al. 2018

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“…Enfin, il a été montré dans plusieurs études que les cellules B CX3CR1 + régulatrices étaient impliquées dans l'établissement de la tolérance orale. En effet, chez des patients souffrant d'allergie alimentaire on retrouve un taux fortement diminué de cellules B CX3CR1 positives dans le sang [60]. De plus, le transfert adoptif de cellules B régulatrices CD5 + CD19 + CX3CR1 + permet de supprimer l'allergie alimentaire dans un modèle murin [61].…”

Section: Les Récepteurs De Chimiokines Dans L'allergie Alimentaireunclassified

Rôles des récepteurs de chimiokines dans les maladies allergiques

Castan

Magnan

Bouchaud

2016

Revue Française d'Allergologie

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“…B cells (BC) are a major fraction of the immune cells in the body. Apart from producing antibodies, B cells also have an immune regulatory function via producing immune regulatory cytokines, such as interleukin (IL)-10 [ 1 ] or transforming growth factor (TGF)-β [ 2 , 3 ]. IL-10 can be produced by several cell types, including dendritic cells, T cells, BCs and monocytes, etc [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Interleukin-13 suppresses interleukin-10 via inhibiting A20 in peripheral B cells of patients with food allergy

Zhu

Linghu

et al. 2016

Oncotarget

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The regulatory B cells (Breg) are important in the body immunity. The differentiation process of Breg is not fully understood yet. Ubiquitin A20 has immune regulatory functions. This study aims to investigate the role of A20 in the regulation of interleukin (IL)-10 in B cells. In this study, B cells were isolated from the peripheral blood samples of healthy subjects and patients with food allergy (FA). The B cells were analyzed by flow cytometry, real time RT-PCR, Western blotting and chromatin immunoprecipitation. We observed that the frequency of Breg and the levels of A20 in B cells were markedly lower in FA patients than in healthy controls. In vitro deletion of A20 compromised the expression of IL-10. B cells in FA patients showed higher levels of histone deacetylase (HDAC)-11 than in healthy subjects. Exposure to IL-13 in the culture induced high levels of HDAC11 in B cells. IL-13 also repressed the expression of A20 in B cells, in which HDAC11 played a critical role via inducing the chromatin remoldeling at the IL-10 promoter locus. Mice with A20-deficient B cells are prone to FA. In summary, ubiquitin A20 can increase the IL-10 expression in B cells, which can be affected by the IL-13-induced HDAC11. To inhibit HDAC11 may have therapeutic potential for FA.

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CX3CR1(+) B Cells Show Immune Suppressor Properties

Abstract: Background:The properties of regulatory B cells are not fully understood. Results: CX3CR1ϩ B cells do not express but contain ␣v␤6 and TGF-␤ and inhibit T cell proliferation. Conclusion: CX3CR1ϩ B cells have immune suppressor properties.

Cited by 14 publications

References 27 publications

Tissue-specific Role of CX₃CR1 Expressing Immune Cells and Their Relationships with Human Disease

Tissue-specific Role of CX₃CR1 Expressing Immune Cells and Their Relationships with Human Disease

Rôles des récepteurs de chimiokines dans les maladies allergiques

Interleukin-13 suppresses interleukin-10 via inhibiting A20 in peripheral B cells of patients with food allergy

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CX3CR1(+) B Cells Show Immune Suppressor Properties

Abstract: Background:The properties of regulatory B cells are not fully understood. Results: CX3CR1ϩ B cells do not express but contain ␣v␤6 and TGF-␤ and inhibit T cell proliferation. Conclusion: CX3CR1ϩ B cells have immune suppressor properties.

Cited by 14 publications

References 27 publications

Tissue-specific Role of CX3CR1 Expressing Immune Cells and Their Relationships with Human Disease

Tissue-specific Role of CX3CR1 Expressing Immune Cells and Their Relationships with Human Disease

Rôles des récepteurs de chimiokines dans les maladies allergiques

Interleukin-13 suppresses interleukin-10 via inhibiting A20 in peripheral B cells of patients with food allergy

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Product

Resources

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Tissue-specific Role of CX₃CR1 Expressing Immune Cells and Their Relationships with Human Disease

Tissue-specific Role of CX₃CR1 Expressing Immune Cells and Their Relationships with Human Disease