2022
DOI: 10.14814/phy2.15304
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CXCL10 is a novel anti‐angiogenic factor downstream of p53 in cardiomyocytes

Abstract: Tumor suppressor protein p53 plays crucial roles in the onset of heart failure. p53 activation results in cardiac dysfunction, at least partially by suppressing angiogenesis. Though p53 has been reported to reduce VEGF production by inhibiting hypoxia‐inducible factor, the anti‐angiogenic property of p53 remains to be fully elucidated in cardiomyocytes. To explore the molecular signals downstream of p53 that regulate vascular function, especially under normoxic conditions, DNA microarray was performed using p5… Show more

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Cited by 3 publications
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“…We previously established CXCL10 as an antiangiogenic agent both in vitro and in vivo in different mouse models of vasoproliferative eye diseases as the VLDR or laser choroidal neovascularization (CNV) model. 14 Beyond the eye, CXCL10 is well known for reducing angiogenesis in sarcoma, 50 after spinal cord injury, 51 or in the heart, 52 suggesting that CXCL10 could be a noteworthy candidate for further research concerning vasoproliferative eye diseases.…”
Section: Discussionmentioning
confidence: 99%
“…We previously established CXCL10 as an antiangiogenic agent both in vitro and in vivo in different mouse models of vasoproliferative eye diseases as the VLDR or laser choroidal neovascularization (CNV) model. 14 Beyond the eye, CXCL10 is well known for reducing angiogenesis in sarcoma, 50 after spinal cord injury, 51 or in the heart, 52 suggesting that CXCL10 could be a noteworthy candidate for further research concerning vasoproliferative eye diseases.…”
Section: Discussionmentioning
confidence: 99%