CXCL9/CXCL10 angiostasis CXC-chemokines in parallel with the CXCL12 as an angiogenesis CXC-chemokine are variously expressed in pre-eclamptic-women and their neonates

Darakhshan, Shokoofeh; Hassanshahi, Gholamhossein; Mofidifar, Zohreh; Soltani, Boshra; Karimabad, Mojgan Noroozi

doi:10.1016/j.preghy.2019.05.001

Cited by 19 publications

(13 citation statements)

References 51 publications

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“…ELR-CXC chemokines including CXCL10 and CXCL12 serve as pro-migratory agents of peripheral blood mononuclear cells (PBMC) such as lymphocytes, monocytes and natural killer (NK) cell types [13,14]. CXCL10 chemokine, known as interferon γ (IFN-γ)-inducible protein 10 (or IP-10) was initially discovered as an IFN-γ-induced protein produced by a wide spectrum of cell types varying from endothelial cells [15], monocytes [16,17], keratinocytes [18], neutrophils [19], dendritic cells [20] and fibroblasts [21] to hepatocytes [22], and mesenchymal cells [23,24]. The common but not specialized receptor for CXCL10 is CXCR3 [25].…”

Section: Introductionmentioning

confidence: 99%

The Involvement of CXC Motif Chemokine Ligand 10 (CXCL10) and Its Related Chemokines in the Pathogenesis of Coronary Artery Disease and in the COVID-19 Vaccination: A Narrative Review

et al. 2021

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Coronary artery disease (CAD) and coronary heart disease (CHD) constitute two of the leading causes of death in Europe, USA and the rest of the world. According to the latest reports of the Iranian National Health Ministry, CAD is the main cause of death in Iranian patients with an age over 35 years despite a significant reduction in mortality due to early interventional treatments in the context of an acute coronary syndrome (ACS). Inflammation plays a fundamental role in coronary atherogenesis, atherosclerotic plaque formation, acute coronary thrombosis and CAD establishment. Chemokines are well-recognized mediators of inflammation involved in several bio-functions such as leucocyte migration in response to inflammatory signals and oxidative vascular injury. Different chemokines serve as chemo-attractants for a wide variety of cell types including immune cells. CXC motif chemokine ligand 10 (CXCL10), also known as interferon gamma-induced protein 10 (IP-10/CXLC10), is a chemokine with inflammatory features whereas CXC chemokine receptor 3 (CXCR3) serves as a shared receptor for CXCL9, 10 and 11. These chemokines mediate immune responses through the activation and recruitment of leukocytes, eosinophils, monocytes and natural killer (NK) cells. CXCL10, interleukin (IL-15) and interferon (IFN-g) are increased after a COVID-19 vaccination with a BNT162b2 mRNA (Pfizer/BioNTech) vaccine and are enriched by tumor necrosis factor alpha (TNF-α) and IL-6 after the second vaccination. The aim of the present study is the presentation of the elucidation of the crucial role of CXCL10 in the patho-physiology and pathogenesis of CAD and in identifying markers associated with the vaccination resulting in antibody development.

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Section: Introductionmentioning

confidence: 99%

The Involvement of CXC Motif Chemokine Ligand 10 (CXCL10) and Its Related Chemokines in the Pathogenesis of Coronary Artery Disease and in the COVID-19 Vaccination: A Narrative Review

et al. 2021

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“…CXCL1 and CXCL12 both exhibit angiogenesis, activities whereas, CXCL9 and CXCL10 have antiangiogenesis properties and display angiostasis activities [19][20][21]. CXCL9 and CXCL10 exert their functions via binding to CXCR3 (a specific receptor for CXCL9 and CXCL10) [22,23]. In an almost similar mode of expression as CXCL10, the CXCL9 is also similarly expressed by a broad range of cell types in response to some members of cytokine family including, IFN-α/β and IFN-γ [24].…”

Section: Introductionmentioning

confidence: 99%

Serum concentration of angiogenic (CXCL1, CXCL12) and angiostasis (CXCL9, CXCL10) CXC chemokines are differentially altered in normal and gestational diabetes mellitus associated pregnancies

Darakhshan

Fatehi

Hassanshahi

et al. 2019

J Diabetes Metab Disord

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Background The present study was aimed and designed to determine the serum levels of CXCL1 and CXCL12 as angiogenesis along with CXCL9 and CXCL10 as angiostasis, chemokines in, Gestational diabetes mellitus mothers (GDMM) and normal pregnancy mothers (NPM) and neonates who delivered by them. Methods We have recruited 63 pregnant GDMM and 63 normal pregnant mothers at the third trimester of pregnancy to this cross-sectional study. Cord blood specimens were obtained from neonates who were delivered from GDMM and NPM. The serum and cord blood levels of chemokines were measured by ELISA in studied groups. Data were analyzed by chi-square and student's t test between two groups. The P-values less than 0.05 were considered significant. Results Our results revealed that the serum levels of CXCL1, CXCL9 and CXCL12 were increased in GDMM, while no alteration was found in the serum levels of CXCL10 when compared to NPM. We have observed that in neonates the serum levels of angiogeneic chemokines followed an inverse fashion when compared to angiostasis chemokines. Interestingly, CXCL1 and CXCL12 were both increased in neonates who were delivered by GDMM, while, CXCL9 and CXCL10 were decreased in neonates delivered by GDMM. Keywords CXCL1. CXCL9. CXCL10. CXCL12. Chemokine. Gestational diabetes mellitus Abbreviations APGAR is a quick test performed on delivered infants at 1 and 5 min after birth BMI Body mass index FBS Fasting blood sugar GCT Glucose challenge test GDM Gestational diabetes mellitus INF Interferon PAI-1, Plasminogen activator inhibitor-1 TNF-α Tumor necrosis factor-α T2DM Type 2 diabetes mellitus MetS Metabolic syndrome HbA1C The hemoglobin A1C ELISA Enzyme linked immunosorbent assay SPSS Statistical package for the Social sciences GDMM Gestational diabetes mellitus mothers NPM Normal pregnancy mothers * Mojgan Noroozi Karimabad

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“…It has been shown that in the plasma of PE women the levels of CXCL9 and CXCL10 are increased, in line with the increase in IFN‐γ 59 . Similarly CXCL9 has been shown to increase in the PE placenta while CXCL10 was unaffected 60 …”

Section: Chemokines and Pementioning

confidence: 89%

“…59 Similarly CXCL9 has been shown to increase in the PE placenta while CXCL10 was unaffected. 60 Collectively, these findings suggest that the CXC chemokines may contribute to the inflammatory pathogenesis of PE and may present good therapeutic targets.…”

Section: Chemok Ine S and Pementioning

confidence: 94%

T lymphocytes and preeclampsia: The potential role of T‐cell subsets and related MicroRNAs in the pathogenesis of preeclampsia

Zolfaghari

ArefNezhad

Parhizkar

et al. 2021

American J Rep Immunol

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Innate and adaptive immune systems have a crucial role in initiating and progressing some pregnancy disorders such as preeclampsia (PE), which is one of the pregnancy‐specific disorders that could result in neonatal and maternal morbidity and mortality. The dysregulation of the spiral artery and inadequate trophoblast invasion lead to PE symptoms through producing various inflammatory cytokines and anti‐angiogenic factors from the placenta. T lymphocytes play a special role in the epithelium and stroma of the human endometrium. CD4+ T helper (Th) cells, Th1/Th2, and Th17/T regulatory (Treg) balance mainly contribute to the establishment of a pregnancy‐favorable environment. This review examined the dysregulation of some cytokines produced from T cells, the dysregulation of the transcription factors of Th cells, the expression of chemokine receptors on T cells, as well as the effects of some factors including vitamin D on the activity of T cells, and finally, the dysregulation of various miRNAs related to T cells, which could cause PE.

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CXCL9/CXCL10 angiostasis CXC-chemokines in parallel with the CXCL12 as an angiogenesis CXC-chemokine are variously expressed in pre-eclamptic-women and their neonates

Cited by 19 publications

References 51 publications

The Involvement of CXC Motif Chemokine Ligand 10 (CXCL10) and Its Related Chemokines in the Pathogenesis of Coronary Artery Disease and in the COVID-19 Vaccination: A Narrative Review

The Involvement of CXC Motif Chemokine Ligand 10 (CXCL10) and Its Related Chemokines in the Pathogenesis of Coronary Artery Disease and in the COVID-19 Vaccination: A Narrative Review

Serum concentration of angiogenic (CXCL1, CXCL12) and angiostasis (CXCL9, CXCL10) CXC chemokines are differentially altered in normal and gestational diabetes mellitus associated pregnancies

T lymphocytes and preeclampsia: The potential role of T‐cell subsets and related MicroRNAs in the pathogenesis of preeclampsia

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