Cyanidin-3-O-glucoside inhibits the UVB-induced ROS/COX-2 pathway in HaCaT cells

He, Yong; Y, Hu; Jiang, Xinwei; Chen, Tianfeng; Ma, Yu-Bin; Wu, Shengjun; Sun, Jianxia; Jiao, Rui; Li, Xiaoling; Deng, Liehua; Bai, Weibin

doi:10.1016/j.jphotobiol.2017.10.006

Cited by 61 publications

(49 citation statements)

References 34 publications

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“…The results of this study indicated that C3G may inhibit UVA‐induced oxidative damage and apoptosis in primary HDFs by increasing the autophagy levels. Our previous studies have shown that C3G inhibits the formation of ROS, reduces DNA damage and p53 expression, and regulates the COX‐2 pathway against UVB‐induced apoptosis in HaCaT keratinocytes. However, whether C3G can reduce ROS by regulating autophagy in a UVB‐induced keratinocyte injury model remained unknown.…”

Section: Discussionmentioning

confidence: 98%

“…previous studies showed that cyanidin-3-o-glucoside (C3G), which is a monomer of anthocyanin, 15 can effectively and safely reduce UVA-induced oxidative damage and apoptosis in primary HDFs. 7 C3G is abundant in foods, such as black rice and black beans, and has several beneficial effects on health, including reducing age-related oxidative stress and improving cognitive function.…”

Section: Ourmentioning

confidence: 99%

“…Studies have shown that milk thistle and olive extracts prevent sun‐induced skin damage, while ellagic acid and rosmarinic acid could prevent damage due to UVB in HaCaT cells . Our previous studies showed that cyanidin‐3‐o‐glucoside (C3G), which is a monomer of anthocyanin, can effectively and safely reduce UVA‐induced oxidative damage and apoptosis in primary HDFs . C3G is abundant in foods, such as black rice and black beans, and has several beneficial effects on health, including reducing age‐related oxidative stress and improving cognitive function.…”

Section: Introductionmentioning

confidence: 99%

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Cyanidin‐3‐o‐glucoside inhibits UVA‐induced human dermal fibroblast injury by upregulating autophagy

Bai

et al. 2019

Photoderm Photoimm Photomed

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Background/Purpose Ultraviolet (UV) A (315‐400 nm) is the UV light that most frequently reaches the Earth's surface and can penetrate the epidermis through to the dermis, causing various issues, including skin aging and skin cancer. The results of our previous studies have shown that the flavonoid monomer cyanidin‐3‐o‐glucoside (C3G) can effectively inhibit primary human dermal fibroblast (HDF) oxidative damage and apoptosis caused by UVA radiation. Many flavonoids can regulate the level of autophagy. However, whether C3G inhibits UVA‐induced oxidative damage to primary HDFs by regulating autophagy levels remains unclear. Methods and Results In this study, we used different doses (0‐12 J/cm2) of UVA to irradiate cells and showed that the expression levels of autophagy‐related gene 5 (Atg5) and microtubule‐associated protein 1 light chain 3 (LC3)‐II in primary HDFs first increased and then decreased. The expression of Atg5 and LC3‐II was significantly decreased under 12 J/cm2 (light‐damage model). C3G increased the levels of Atg5 and LC3‐II. Primary HDFs were pretreated with C3G, followed by treatment with the autophagy inhibitor 3‐methyladenine (3‐MA) after 12 J/cm2 UVA irradiation. The inhibitory effects of C3G on morphological changes, oxidative damage, and apoptosis in primary HDFs induced by UVA were significantly decreased. Conclusion C3G can inhibit UVA‐induced damage to primary HDFs by inducing autophagy. These results provide a theoretical basis for the application of natural compounds to resist light damage to the skin in the future.

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Section: Discussionmentioning

confidence: 98%

Section: Ourmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cyanidin‐3‐o‐glucoside inhibits UVA‐induced human dermal fibroblast injury by upregulating autophagy

Bai

et al. 2019

Photoderm Photoimm Photomed

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“…Moreover, shoot extracts from halophytes showed superior Fe-reducing power and DPPH radical scavenging ability than glycophytes (Ksouri et al, 2012), implying polyphenols are also a key player to decrease ROS damage in halophytes. Similarly, the key role of the cyanidin-3-O-glucoside, as a typical anthocyanin, as a component of the UVB-protection mechanism was shown in both plant (Sgherri, Scattino, Pinzino, Tonutti, & Ranieri, 2015) and mammalian (He et al, 2017) cells.…”

Section: Superior K + Retention May Be Related To Higher Nonenzymatmentioning

confidence: 85%

Revealing mechanisms of salinity tissue tolerance in succulent halophytes: A case study for Carpobrotus rossi

Zeng

Shabala

Maksimović

et al. 2018

Plant Cell & Environment

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Efforts to breed salt tolerant crops could benefit from investigating previously unexplored traits. One of them is a tissue succulency. In this work, we have undertaken an electrophysiological and biochemical comparison of properties of mesophyll and storage parenchyma leaf tissues of a succulent halophyte species Carpobrotus rosii ("pigface"). We show that storage parenchyma cells of C. rossii act as Na sink and possessed both higher Na sequestration (298 vs. 215 mM NaCl in mesophyll) and better K retention ability. The latter traits was determined by the higher rate of H -ATPase operation and higher nonenzymatic antioxidant activity in this tissue. Na uptake in both tissues was insensitive to either Gd or elevated Ca ruling out involvement of nonselective cation channels as a major path for Na entry. Patch-clamp experiments have revealed that Caprobrotus plants were capable to downregulate activity of fast vacuolar channels when exposed to saline environment; this ability was higher in the storage parenchyma cells compared with mesophyll. Also, storage parenchyma cells have constitutively lower number of open slow vacuolar channels, whereas in mesophyll, this suppression was inducible by salt. Taken together, these results provide a mechanistic basis for efficient Na sequestration in the succulent leaf tissues.

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“…CG is a potent antioxidant and protects against oxidative damage 157 . CG was also reported to reduce UVB-induced damage in vitro [158][159][160] and in vivo 161,162 .…”

Section: Chrysantheminmentioning

confidence: 93%

Ultraviolet A protective potential of plant extracts and phytochemicals

Škařupová

Vostalová

Svobodová

2020

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Chronic exposure to solar radiation is related to an increased incidence of various skin disorders, including premature skin aging and melanoma and non-melanoma skin cancers. Ultraviolet (UV) photons in particular are responsible for skin damage. Solar UV photons mainly belong to UVA wavebands, however UVA radiation has been mostly ignored for a long time. At the cellular level, UVA photons mainly provoke indirect oxidative damage to biomolecules via the massive generation of unstable and highly reactive compounds. Human skin has several effective mechanisms that forestall, repair and eliminate damage caused by solar radiation. Regardless, some damage persists and can accumulate with chronic exposure. Therefore, conscious protection against solar radiation (UVB+UVA) is necessary. Besides traditional types of photoprotection such as sunscreen use, new strategies are being searched for and developed. One very popular protective strategy is the application of phytochemicals as active ingredients of photoprotection preparations instead of synthetic chemicals. Phytochemicals usually possess additional biological activities besides absorbing the energy of photons, and those properties (e.g. antioxidant, anti-inflammatory) magnify the protective potential of phytochemicals and extracts. Therefore, compounds of natural origin are in the interest of researchers as well as developers. In this review, only studies on UVA protection with well-documented experimental conditions are summarized. This article includes 17 well standardized plant extracts (Camellia sinensis (L.) Kuntze, Silybum marianum L. Gaertn., Punica granatum L., Polypodium aureum L., Vaccinium myrtillus L., Lonicera caerulea L., Thymus vulgaris L., Opuntia ficus-indica (L.) Mill., Morinda citrifolia L., Aloe vera (L.) Burm.f., Oenothera paradoxa Hudziok, Galinsoga parviflora Cav., Galinsoga quadriradiata Ruiz et Pavón, Hippophae rhamnoides L., Cola acuminata Schott & Endl., Theobroma cacao L. and Amaranthus cruentus L.) and 26 phytochemicals.

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Cyanidin-3-O-glucoside inhibits the UVB-induced ROS/COX-2 pathway in HaCaT cells

Cited by 61 publications

References 34 publications

Cyanidin‐3‐o‐glucoside inhibits UVA‐induced human dermal fibroblast injury by upregulating autophagy

Cyanidin‐3‐o‐glucoside inhibits UVA‐induced human dermal fibroblast injury by upregulating autophagy

Revealing mechanisms of salinity tissue tolerance in succulent halophytes: A case study for Carpobrotus rossi

Ultraviolet A protective potential of plant extracts and phytochemicals

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