Cyanidin-3-O-glucoside protects against cadmium-induced dysfunction of sex hormone secretion via the regulation of hypothalamus-pituitary-gonadal axis in male pubertal mice

Liu, Xusheng; Guo, Jingting; Jiang, Xingwei; Sun, Jianxia; Tian, Lingmin; Jiao, Rui; Tang, Yunge; Bai, Weibin

doi:10.1016/j.fct.2019.04.033

Cited by 46 publications

(20 citation statements)

References 46 publications

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“…We measured testosterone plasma levels at different time points during the adolescent period (from PDN21 to PDN60). Our results show that testosterone levels increase with age, as previously reported [50,51]. However, although we observed more antagonistic behaviors in C57BL/6J pubescent mice, the results did not show higher testosterone levels than CD1 and SCID Beige mice.…”

Section: Discussionsupporting

confidence: 82%

Postweaning Grouping as a Strategy to Reduce Singly Housed Male Mice

Grífols

Zamora

Ortega-Saez

et al. 2020

Animals

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Rearing laboratory mice in groups is important since social isolation after weaning induces brain alterations, which entails behavioral abnormalities in adulthood. Age is an important factor when grouping males of different litters due to inter-male aggressiveness. The aim of this study was to determine whether newly weaned mice could safely be grouped with late juvenile or early and late pubescent mice, and whether cage cleaning, the number of the hosting group members and testosterone plasma levels have any influence. Newly weaned C57BL/6J, CD1, and SCID Beige male mice were systematically grouped with same strain late juvenile, early or late pubescent male mice in clean or dirty cages of 1, 2 or 3 hosting members. We also analyzed plasma testosterone levels at different postnatal days. Our result showed that only strain and hosting male’s age influence agonistic behavior toward newly weaned mice. Thus, in order not to house a recently weaned male alone, we would recommend grouping it with late juvenile same strain mice in all studied strains. In the same way, CD1 and SCID Beige pubescent mice will admit a newly weaned mouse in their group. However, we would not recommend grouping newly weaned and pubescent C57BL/6J males.

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Section: Discussionsupporting

confidence: 82%

Postweaning Grouping as a Strategy to Reduce Singly Housed Male Mice

Grífols

Zamora

Ortega-Saez

et al. 2020

Animals

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“…In addition, this anthocyanin also upregulated the activities of the MAPK and PKA signalling pathways [90], promoting steroid production. Cyanidin-3-glucoside (20) was also reported to improve the expression levels of steroidogenic proteins (StAR, Hsd3b, and Cyp11a1) and of the LH receptor within the testes of mice exposed to cadmium, an important neuroendocrine disruptor [91]. Thus, anthocyanidins may promote testosterone production by Leydig cells through their antioxidant properties.…”

Section: Anthocyanidinsmentioning

confidence: 99%

Improvement of Testicular Steroidogenesis Using Flavonoids and Isoflavonoids for Prevention of Late-Onset Male Hypogonadism

Martin

Touaibia

2020

Antioxidants

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Androgen production, being important for male fertility, is mainly accomplished by the Leydig cells from the interstitial compartment of the testis. Testosterone plays a critical role in testis development, normal masculinization, and the maintenance of spermatogenesis. Within seminiferous tubules, appropriate Sertoli cell function is highly dependent on testicular androgen levels and is essential to initiate and maintain spermatogenesis. During aging, testosterone production by the testicular Leydig cells declines from the 30s in humans at a rate of 1% per year. This review outlines the recent findings regarding the use of flavonoids and isoflavonoids to improve testosterone production, contributing to normal spermatogenesis and preventing age-related degenerative diseases associated with testosterone deficiency. With the cumulation of information on the actions of different flavonoids and isoflavonoids on steroidogenesis in Leydig cells, we can now draw conclusions regarding the structure-activity relationship on androgen production. Indeed, flavonoids having a 5,7-dihydroxychromen-4-one backbone tend to increase the expression of the steroidogenic acute regulatory protein (StAR), being critical for the entry of cholesterol into the mitochondria, leading to increased testosterone production from testis Leydig cells. Therefore, flavonoids and isoflavonoids such as chrysin, apigenin, luteolin, quercetin, and daidzein may be effective in delaying the initiation of late-onset hypogonadism associated with aging in males.

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“…Single antioxidants and their combinations offer protection against AD. Cyanidin-3- O -glucoside is effective in alleviating the toxicity of Cd [67]. It might be possible to eliminate toxic metals through their chelation with ANTs [68].…”

Section: Alzheimer’s Disease and Oxidative Stressmentioning

confidence: 99%

Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease

2019

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Anthocyanins (ANTs) are plant pigments that belong to a flavanol class of polyphenols and have diverse pharmacological properties. These compounds are primarily found in fruits and vegetables, with an average daily intake of 180 mgd−1 of these compounds in the developed world. ANTs are potent antioxidants that might regulate the free radical-mediated generation of amyloid peptides (Abeta-amyloids) in the brain, which causes Alzheimer’s disease (AD). This study presents a literature review of ANTs from different berries and their potential therapeutic value, with particular emphasis on neurodegenerative AD, which owing to oxidative stress. This review also highlights reactive oxygen species (ROS) generation through energy metabolism, nitrogen reactive species, the role of transition metals in generating ROS, and the radical-quenching mechanisms of natural antioxidants, including ANTs. The current status of the bioavailability, solubility, and structure activity relationship of ANTs is discussed herein.

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Cyanidin-3-O-glucoside protects against cadmium-induced dysfunction of sex hormone secretion via the regulation of hypothalamus-pituitary-gonadal axis in male pubertal mice

Cited by 46 publications

References 46 publications

Postweaning Grouping as a Strategy to Reduce Singly Housed Male Mice

Postweaning Grouping as a Strategy to Reduce Singly Housed Male Mice

Improvement of Testicular Steroidogenesis Using Flavonoids and Isoflavonoids for Prevention of Late-Onset Male Hypogonadism

Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease

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