Cyanidin-3-O-β-glucoside inactivates NLRP3 inflammasome and alleviates alcoholic steatohepatitis via SirT1/NF-κB signaling pathway

Zhou, Y.; Wang, Sufan; Wan, Ting; Huang, Yuanling; Pang, Nengzhi; Jiang, Xuye; Gu, Yingying; Zhang, Zhenfeng; Luo, Jing; Yang, Lili

doi:10.1016/j.freeradbiomed.2020.08.006

Cited by 59 publications

(32 citation statements)

References 27 publications

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“…As we know, inflammation plays an important role in inducing osteoclast differentiation (Z. Liu et al, 2019; Loi et al, 2016). Our subsequent study confirmed that miR‐128 promoted osteoclast differentiation in mice via targeting the SIRT1/NF‐κB signaling pathway (G. Shen et al, 2020), which is an important inflammation pathway (G. Shen et al, 2020; Zhou et al, 2020). By using the osteoclastic deletion of miR‐128, we further demonstrated that miR‐128 inhibited ovariectomy‐triggered osteoclastogenesis, and exerted a protective effect against bone loss in mice (G. Shen et al, 2020).…”

Section: Effect Of Mir‐128 On Bone Homeostasis and Osteoporosissupporting

confidence: 68%

“…Hence, miR-128 may play a negative role in osteoblastogenesis but further molecular mechanisms still deserve to be explored (Table 2). Zhou et al, 2020). By using the osteoclastic deletion of miR-128, we further demonstrated that miR-128 inhibited ovariectomy-triggered osteoclastogenesis, and exerted a protective effect against bone loss in mice (G. Shen et al, 2020).…”

Section: Mir-128 and Osteoblastogenesismentioning

confidence: 86%

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The emerging role of miR‐128 in musculoskeletal diseases

Shang

Shen

Chen

et al. 2020

Journal Cellular Physiology

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MicroRNA-128 (miR-128) is associated with cell proliferation, differentiation, migration, apoptosis, and survival. Genetic analysis studies have demonstrated that miR-128 participates in bone metabolism, which involves bone marrow-derived mesenchymal stem cells, osteoblasts, osteoclasts, and adipocytes. miR-128 also participates in regeneration of skeletal muscles by targeting myoblast-associated proteins. The deregulation of miR-128 could lead to a series of musculoskeletal diseases. In this review, we discuss recent findings of miR-128 in relation to bone metabolism and muscle regeneration to determine its potential therapeutic effects in musculoskeletal diseases, and to propose directions for future research in this significant field.

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Section: Effect Of Mir‐128 On Bone Homeostasis and Osteoporosissupporting

confidence: 68%

Section: Mir-128 and Osteoblastogenesismentioning

confidence: 86%

The emerging role of miR‐128 in musculoskeletal diseases

Shang

Shen

Chen

et al. 2020

Journal Cellular Physiology

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“…Oryza sativa C3G ↓NLRP3 ↓NF-κB, [37] Lonicera caerulea C3G ↑AMPK ↓Lipid accumulation ↓F4/80 ↓IL-1β [38] Table 1. Cont.…”

Section: Hypercholesterolemiamentioning

confidence: 99%

Anthocyanins: Promising Natural Products with Diverse Pharmacological Activities

et al. 2021

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Anthocyanins are natural products that give color to plants. As natural plant pigments, anthocyanins also have a series of health-promoting benefits. Many researchers have proved that anthocyanins have therapeutic effects on diseases, such as circulatory, nervous, endocrine, digestive, sensory, urinary and immune systems. Additionally, a large number of studies have reported that anthocyanins have an anticancer effect through a wide range of anti-inflammatory and antioxidant effects. The anti-disease impact and mechanism of anthocyanins are diverse, so they have high research value. This review summarizes the research progress of anthocyanins on the pharmacological agents of different diseases to provide references for subsequent research.

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“…A recently published study also confirmed that C-3-G shows strong potential to overcome the adverse effect of alcohol. It found that C-3-G alleviated alcoholic steatohepatitis by inactivating NLRP3 inflammasome and Sirtuin1 (SIRT1)/NF-κB signaling pathway [ 107 ].…”

Section: Bioactive Compounds Ameliorate Ald Via Multiple Pathwaysmentioning

confidence: 99%

Protective Mechanism of Edible Food Plants against Alcoholic Liver Disease with Special Mention to Polyphenolic Compounds

et al. 2021

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Alcoholic liver disease (ALD) is one type of liver disease, causing a global healthcare problem and mortality. The liver undergoes tissue damage by chronic alcohol consumption because it is the main site for metabolism of ethanol. Chronic alcohol exposure progresses from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which further lead to fibrosis, cirrhosis, and even hepatocellular cancer. Therapeutic interventions to combat ALD are very limited such as use of corticosteroids. However, these therapeutic drugs are not effective for long-term usage. Therefore, additional effective and safe therapies to cope with ALD are urgently needed. Previous studies confirmed that edible food plants and their bioactive compounds exert a protective effect against ALD. In this review article, we summarized the hepatoprotective potential of edible food plants and their bioactive compounds. The underlying mechanism for the prevention of ALD by edible food plants was as follows: anti-oxidation, anti-inflammation, lipid regulation, inhibition of apoptosis, gut microbiota composition modulation, and anti-fibrosis.

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Cyanidin-3-O-β-glucoside inactivates NLRP3 inflammasome and alleviates alcoholic steatohepatitis via SirT1/NF-κB signaling pathway

Cited by 59 publications

References 27 publications

The emerging role of miR‐128 in musculoskeletal diseases

The emerging role of miR‐128 in musculoskeletal diseases

Anthocyanins: Promising Natural Products with Diverse Pharmacological Activities

Protective Mechanism of Edible Food Plants against Alcoholic Liver Disease with Special Mention to Polyphenolic Compounds

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