Cyanidin 3-Rutinoside and Cyanidin 3-Xylosylrutinoside as Primary Phenolic Antioxidants in Black Raspberry

Tulio, Artemio Z.; Reese, R. Neil; Wyzgoski, Faith J.; Rinaldi, Peter L.; Fu, Ruiling; Scheerens, Joseph C.; Miller, Alexander

doi:10.1021/jf072313k

Cited by 149 publications

(116 citation statements)

References 39 publications

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“…In the present study, both anthocyanidin and proanthocyanidin levels were significantly higher in L-ORAC extracts of the red type than of the green type; specifically, the proanthocyanidin level in the red type was almost twice that of the green type. Anthocyanins and their aglycons are potent antioxidants (27,28) that prevent CCl4-induced liver damage in rats (29). Moreover, proanthocyanidins are reported to exert higher radical-scavenging activities than anthocyanins (26) or activities that are fifty times higher than vitamin E (30) Therefore, anthocyanidin and proanthocyanidin are considered to contribute to the higher value of L-ORACFL in the red type and significant suppression of the TBARS level in mice fed the red type of I. aquatica.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Red-Stemmed Type of Ipomoea aquatica Forsk against CCl4-Induced Oxidative Damage in Mice

Hirai

Ishibuchi

Watabe

et al. 2011

J Nutr Sci Vitaminol

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Summary Water spinach ( Ipomoea aquatica Forsk; I. aquatica ) of the green-stemmed type (green type) is widely consumed, but there also exists a red-stemmed variety (red type). In the present study, the antioxidant capacity of the red type was compared to that of the green type in carbon tetrachloride (CCl 4 )-treated mice. CCl 4 -induced thiobarbituric acid reactive substrate (TBARS) formation in the liver was significantly suppressed in mice fed 5% redtype I. aquatica , while the green type showed no effect. Hydrophobic oxygen radical absorbance capacity (H-ORAC FL ) in the red type showed a lower level than that in the green type; however, lipophilic ORAC (L-ORAC FL ) and total-ORAC FL levels were significantly higher in the red type than in the green type. ␣ -Tocopherol, anthocyanidin/proanthocyanidin, and ␤ -carotene contents were all significantly higher in the red type than in the green type. These results suggest that the wild red-type I. aquatica contains certain lipophilic components that exert antioxidant capacities not only in vitro but also in vivo. Such effective components in the red type would be beneficial phytochemicals for suppressing several diseases related to oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Red-Stemmed Type of Ipomoea aquatica Forsk against CCl4-Induced Oxidative Damage in Mice

Hirai

Ishibuchi

Watabe

et al. 2011

J Nutr Sci Vitaminol

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“…La identificación estructural fue corroborada por RMN (H 1 ) y (C 13 ) bajo comparación con datos reportados en literatura. Los compuestos fueron identificados como cianidina 3-O-rutinósido (2 ) (Tulio et al, 2008); cianidina 3-O-(6"-O-malonil)-glucopiranósido (3 ) (Bridle et al, 1984), pelargonidina 3-O-(6"-O-malonil)-glucopiranósido (5) (Toki et al, 1995), y peonidina 3-O-(6"-O-malonil)-glucopiranósido (6 ) (Fossen et al, 2001). Aunque ya ha sido identificada en un trabajo previo (Žilić et al, 2012), esta es la primera vez que la antocianina cianidina 3-O-rutinósido es aislada de granos de maíz de color púrpura, mientras que las demás antocianinas ya han sido aisladas de otras fuentes de maíz.…”

Section: Antocianinas Monoméricas Aisladas a Partir Del Grano Del Fenunclassified

COMPOSICIÓN DE ANTOCIANINAS MONOMÉRICAS DE CINCO FENOTIPOS DE MAÍZ COLOREADO (Zea mays) DE LA REGIÓN CENTRAL COLOMBIANA

Quiñones

Coy-Barrera

2015

Rev. Fac. Cienc.

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Recibido 24-03-2015, aceptado 29-05-2015, versión final 08-06-2015.Artículo Investigación RESUMEN: Colombia cuenta con variedades nativas de maíz (Zea mays L.) que lentamente se han ido perdiendo, a pesar de su interés potencial para programas de mejoramiento genético y uso nutracéutico. En Colombia, el maíz coloreado es poco conocido y escasamente aprovechado, el cual si ha sido investigado en otros países. Como parte de nuestros estudios del aprovechamiento de materiales vegetales nativos, cinco accesiones locales de maíz coloreado, provenientes de la región cundiboyacense colombiana, fueron recuperadas y cultivadas en condiciones agroecológicas. Se caracterizaron los extractos metanólicos obtenidos de sus granos, evaluando el contenido de antocianinas totales y la capacidad captadora de radicales DPPH • , cuyos valores estuvieron entre 21-168 mg eq cianidina 3-glucósido/kg grano seco y 195-412 µM Trolox/g grano seco, respectivamente. Se determinaron los perfiles de antocianinas de cada fenotipo mediante HPLC-DAD-MS. Se identificaron tentativamente nueve antocianinas, cuatro de ellas presentes en todos los fenotipos. Tales perfiles permitieron realizar una discriminación de los cinco fenotipos a partir de análisis multivariado. La información estructural se apoyó en el aislamiento y elucidación de cuatro de las antocianinas a partir del extracto enriquecido del fenotipo púrpura.PALABRAS CLAVE: Antocianinas, captura de radicales libres, HPLC, maíz coloreado, Zea mays.ABSTRACT: Colored corn is little known and poorly exploited in Colombia. Colombia has native corn varieties that are being slowly lost on spite of its relevance in breeding programs. As part of our research focused on native plants, five local landraces of colored corn from central Colombia were collected and cultivated under agroecological conditions. The grain were extracted with metanol and analyzed for total anthocyanins and DPPH• radical-scavenging capacity, whose values were between 21-168 mg eq C3G/kg dry grain and

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“…The rationale for the choice of BRB for study is their high content of anthocyanins and ellagic acid and their high antioxidant potential relative to most other berry types (9). The rationale for obtaining berries from a single farm stems from observations that the contents of ellagic acid and anthocyanins in BRB obtained from 12 different farms in Ohio during a single year can vary as much as two to threefold (10). The BRB are picked mechanically, washed with water, and placed in a -20 • C freezer on the farm within 2-4 h of the time of picking.…”

Section: Preparation Of Freeze-dried Berry Powdersmentioning

confidence: 99%

Cancer Prevention with Berries: Role of Anthocyanins

Stoner

Wang

Sardo

et al. 2010

Bioactive Compounds and Cancer

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Key Points1. Berries have been part of the human diet for many centuries. They are a rich source of known chemopreventive agents including provitamin A carotenoids, C, E, and folate, calcium and selenium, simple and complex phenols, and phytosterols. 2. It has been found that freeze-dried berries can inhibit cancer development in the esophagus, colon, oral cavity, and mammary gland of rodents. Studies suggest that the most active inhibitory compounds in berries are the anthocyanins, the most abundant flavonoids in berries. 3. Berries function to inhibit carcinogenesis by reducing the growth rate of premalignant cells, inhibiting angiogenesis and inflammation, and stimulating apoptosis, cell differentiation, and cell adhesion. Molecular studies indicate that berries exhibit a genome-wide effect on the expression of genes associated with these different cellular functions. 4. The ability of berries to prevent cancer is likely due to the localized absorption of berry compounds into target tissues. Topical treatment of oral dysplastic lesions with a black raspberry gel for a period of 6 weeks resulted in a reduction in histological grade and restoration of loss of heterozygosity (LOH) in about 50% of the lesions. Consumption of black raspberry powder (60 g/day) in a slurry of water for only 2-4 weeks reduced the Ki-67 cell proliferation index in colon tumors taken at surgery from cancer patients. 5. The protective effects of berries on cancer development at specific sites in animals are impressive; however, there is little evidence that berry consumption leads to significant side effects either in animals or in humans. It seems reasonable to suggest that berries be part of the daily diet, and that in individuals at high risk, the daily consumption of several grams of berry powder could well elicit protection.

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Cyanidin 3-Rutinoside and Cyanidin 3-Xylosylrutinoside as Primary Phenolic Antioxidants in Black Raspberry

Cited by 149 publications

References 39 publications

Protective Effect of Red-Stemmed Type of Ipomoea aquatica Forsk against CCl4-Induced Oxidative Damage in Mice

Protective Effect of Red-Stemmed Type of Ipomoea aquatica Forsk against CCl4-Induced Oxidative Damage in Mice

COMPOSICIÓN DE ANTOCIANINAS MONOMÉRICAS DE CINCO FENOTIPOS DE MAÍZ COLOREADO (Zea mays) DE LA REGIÓN CENTRAL COLOMBIANA

Cancer Prevention with Berries: Role of Anthocyanins

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