Cyanotoxins in desert environments may present a risk to human health

Metcalf, James S.; Richer, Renee; Cox, Paul Alan; Codd, Geoffrey A.

doi:10.1016/j.scitotenv.2012.01.053

Cited by 125 publications

(77 citation statements)

References 37 publications

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“…For example, in vitro bioassays have revealed a stimulation of mammalian estrogenic activity by cyanobacterial exudates (Sychrova et al, 2012) and a stimulation of proinflammatory responses by MC-LR; the latter effect not being attributable to the long-known inhibition of protein phosphatases by MCs (Adamovsky et al, 2015). Recognition of the roles of exposure media and routes via which cyanotoxins may present risks to human health has also been increased: one of the first risk assessments of exposure to cyanotoxins from terrestrial sources concerned potential inhalation exposure to airborne MCs from cyanobacterial desert crusts (Metcalf et al, 2012).…”

Section: Fate Impact and Health Effectsmentioning

confidence: 99%

Toxic cyanobacteria and cyanotoxins in European waters – recent progress achieved through the CYANOCOST Action and challenges for further research

et al. 2017

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This review aims to summarise the outcomes of some recent European research concerning toxic cyanobacteria and cyanotoxins, with an emphasis on developments within the framework of the CYANOCOST Action: COST Action ES1105, Cyanobacterial Blooms and Toxins in Water Resources: Occurrence, Impacts and Management. Highlights of the Action include phycological and ecological studies, development of advanced techniques for cyanotoxin analysis, elucidation of cyanotoxin modes of action, management techniques to reduce cyanobacterial mass development, and research on methods and practices for cyanotoxin removal during drinking water treatment. The authors have identified a number of gaps in knowledge. Proposed directions for future research on toxic cyanobacteria and cyanotoxins are also discussed.

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Section: Fate Impact and Health Effectsmentioning

confidence: 99%

Toxic cyanobacteria and cyanotoxins in European waters – recent progress achieved through the CYANOCOST Action and challenges for further research

et al. 2017

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“…In the Pacific island of Guam, BMAA exposure has been associated with an elevated prevalence of sporadic ALS and ALS/PDC (Murch et al, 2004a). In the Middle East, exposure to BMAA is presumed to include inhalation of disturbed desert dust which harbors cyanobacteria and their toxins Metcalf et al, 2012;Powell et al, 2013;Richer et al, 2014). In Guam, it has been suggested that eating flying foxes as a delicacy, along with feral animals and food products made of the starchy interior of the cycad seed all contribute to the BMAA found within the neuroproteins of the Chamorro people (Murch et al, 2004b;Banack et al, 2006Banack et al, , 2009.…”

Section: Introductionmentioning

confidence: 99%

Detection of cyanobacterial neurotoxin β-N-methylamino-l-alanine within shellfish in the diet of an ALS patient in Florida

Banack

Metcalf

Bradley

et al. 2014

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“…Moreover, some studies state that MCs can be transferred along food chain [33], suggesting a potential risk for human consumption of contaminated food products. Furthermore, a study by Metcalf and associates [34] showed that the presence of MCs in desert crusts had substantial implications for human health via inhalation.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Primary Liver Cancer in Serbia and Possible Connection With Cyanobacterial Blooms

Svirčev

Drobac

Tokodi

et al. 2013

Journal of Environmental Science and Health, Part C

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Today, the occurrence of harmful cyanobacterial blooms is a common phenomenon and a potential global health problem. Cyanobacteria can produce metabolites highly toxic to humans. More than 80% of reservoirs used for water supply in Central Serbia have bloomed over the past 80 years. A 10-year epidemiological study showed a significant increase in the incidence of primary liver cancer (PLC) in the regions where water from the blooming reservoirs was used for human consumption. At the same time, no correlation was found between the incidence of PLC and other risk factors, such as cirrhosis and hepatitis viruses. Given the strong association with PLC induction and various known possible mechanisms of carcinogenic action, it is highly possible that, cyanotoxins--acting as initiator and promoter--may be the major risk factor that acts synergistically with other risk factors to cause increased incidence of PLC. However, at present, it is still not certain whether cyanotoxins alone were sufficient to induce PLC. Therefore, additional assessment of the health risks that may arise from human exposure to cyanotoxins is advisable.

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Cyanotoxins in desert environments may present a risk to human health

Cited by 125 publications

References 37 publications

Toxic cyanobacteria and cyanotoxins in European waters – recent progress achieved through the CYANOCOST Action and challenges for further research

Toxic cyanobacteria and cyanotoxins in European waters – recent progress achieved through the CYANOCOST Action and challenges for further research

Detection of cyanobacterial neurotoxin β-N-methylamino-l-alanine within shellfish in the diet of an ALS patient in Florida

Epidemiology of Primary Liver Cancer in Serbia and Possible Connection With Cyanobacterial Blooms

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