2011
DOI: 10.1007/bf03245892
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Cyanuric chloride catalysed rapid conversion of β-ketoesters into β-enaminoesters under mild and solvent-free conditions

Abstract: Cyanuric chloride is shown to be an extremely efficient catalyst for the synthesis of β-enaminoesters from β-ketoesters under solvent-free conditions by grinding in a mortar with pestle at 25 °C. A short reaction time, an inexpensive and easily available catalyst, mild reaction conditions and excellent yields of the products are attractive features of this methodology.

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Cited by 4 publications
(2 citation statements)
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“…Kamble et al, [63] developed the solvent-free synthesis of β-enaminoesters into β-ketoesters using a cyanuric acid catalyst. The reaction involved grinding at 25 C in a mortar pestle.…”
Section: Synthesis Of 14-dihydropyridines: Hantzsch Reactionmentioning
confidence: 99%
“…Kamble et al, [63] developed the solvent-free synthesis of β-enaminoesters into β-ketoesters using a cyanuric acid catalyst. The reaction involved grinding at 25 C in a mortar pestle.…”
Section: Synthesis Of 14-dihydropyridines: Hantzsch Reactionmentioning
confidence: 99%
“…Initially amine precursor, a diketone precursor and cyanuric chloride were added to an algae mortar. [140] Upon grinding the reaction was initiated. The concept was excellent for syntheses of model secondary enamino ketone.…”
Section: Synthesis Of Starting Materials and Optimization Studiesmentioning
confidence: 99%