CyberKnife therapy of 24 multiple brain metastases from lung cancer: A case report

Yang, Guoren; Wang, Yishan; Wang, Yuanyuan; Lin, Shiji; Sun, Di

doi:10.3892/ol.2013.1383

Cited by 4 publications

(5 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared with GK, CK is a relatively non-invasive treatment modality. It could provide more accurate target localization, higher tumor control, and lower toxicity with repeated treatments for recurrent metastases [ 88 , 91 ]. To date, there is robust evidence supporting the efficacy of CK in treating BM from different primary cancers.…”

Section: Radiotherapymentioning

confidence: 99%

Brain metastases from hepatocellular carcinoma: recent advances and future avenues

Wang

Lin

et al. 2017

Oncotarget

View full text Add to dashboard Cite

The incidence of brain metastases from hepatocellular carcinoma (BMHCC) is becoming more frequent than that of the past as a result of prolonged survival of patients with HCC. Compared with brain metastases from other types of cancer, BMHCC tends to exhibit a high incidence of intracerebral hemorrhage (ICH) and poor liver function. Unfortunately, the prognosis is extremely poor for patients with BMHCC owing to the limited treatment selection. Currently, optimal treatment requires multidisciplinary approaches including surgery, whole-brain radiation therapy and stereotactic radiosurgery. Besides these traditional approaches, novel treatments such as target therapy and immunotherapy provide an opportunity to improve the survival of these patients. This review provides an overview of the incidence, characteristics, prognosis, and current and potential future management strategies for BMHCC.

show abstract

Section: Radiotherapymentioning

confidence: 99%

Brain metastases from hepatocellular carcinoma: recent advances and future avenues

Wang

Lin

et al. 2017

Oncotarget

View full text Add to dashboard Cite

show abstract

“…The CyberKnife design coupled with real-time imaging have improved accurate target localization and dose delivery for brain tumors allowing higher biologically effective dose delivery without increased incidence of toxicity, which showed to be an effective technique for BMs. [ 25 ] There is one case reporting the repeated SRS using Cyberknife, and the procedure of the repeated SRT was controlled well and also reduced the incidence of toxicity. From Table 3 , we found when planning Stereotactic intracranial treatment, the emphasis should be on the total intracranial tumor volume involved rather than the number of lesions to be treated; the cumulative intracranial tumor volume of the present case was 11.129 cc, which is in well agreement with the previously published results.…”

Section: Discussionmentioning

confidence: 99%

“…The CyberKnife described in 1997 is an image-guided frameless robotic technology for whole-body radiosurgery; it can be used for classic single-fraction radiosurgery and for hypofractionated treatments. The CyberKnife design coupled with real-time imaging have improved accurate target localization and dose delivery for brain tumors allowing higher biologically effective dose delivery without increased incidence of toxicity, which showed to be an effective technique for BMs [25] . There is one case reporting the repeated SRS using Cyberknife, and the procedure of the repeated SRT was controlled well and also reduced the incidence of toxicity.…”

Section: Discussionmentioning

confidence: 99%

Re-irradiation of multiple brain metastases using CyberKnife stereotactic radiotherapy

Zhou

Wu²,

Zhu³

et al. 2021

Medicine

View full text Add to dashboard Cite

Introduction: Brain metastasis (BM) is the commonest adult intracranial malignancy and many patients with brain metastases require two course radiotherapy. Re-irradiation is frequently performed in Radiotherapy (RT) departments for multiple brain metastases.Patient concerns: We present a case of a 55-year-old male patient suffering from brain metastases, who had previously received whole-brain radiotherapy (WBRT) and first CyberKnife Stereotactic Radiotherapy (CKSRT) for metastases, presented with a recurrence of metastasis and new lesions in the brain.Diagnoses: An enhanced computed tomography (CT) scan of the brain revealed abnormalities with double-dosing of intravenous contrast that identified >10 lesions scattered in the whole brain.Interventions: Re-irradiation was performed using CKSRT. The patient was treated with 30 Gy in 5 fractions for new lesions and 25 Gy in 5 fractions for lesion that were locally recurrent and close to brainstem lesions.Outcome: The lesions were well-controlled, and the headache of the patient was significantly relieved one month after radiotherapy. The total survival time of the patients was 17 months from the beginning of the Cyberknife treatment. Conclusion:The present case report demonstrates that CyberKnife therapy plays a significant role in the repeated radiotherapy for multiple metastatic brain tumors. CKSRT can be used as a salvage method in recurrent multiple brain metastases.

show abstract

“…Brain metastases from lung cancer have become significant areas of focus in oncology research, including in genomic studies, and in the development of modern radiotherapy techniques and novel anticancer agents (12)(13)(14). A number of patients with few cerebral metastases receive radiosurgery, either alone or in combination with whole-brain irradiation.…”

Section: Discussionmentioning

confidence: 99%

Number of cerebral lesions predicts freedom from new brain metastases after radiosurgery alone in lung cancer patients

et al. 2015

View full text Add to dashboard Cite

Abstract. Numerous patients with few brain metastases receive radiosurgery, either alone or in combination with whole-brain irradiation. The addition of whole-brain irradiation to radiosurgery reduces the rate of intracerebral failures, particularly the development of new cerebral lesions distant from those treated with radiosurgery. Less intracerebral failures mean less neurocognitive deficits. However, whole-brain irradiation itself may lead to a decline in neurocognitive functions. Therefore, a number of physicians have reservations with regard to adding whole-brain irradiation to radiosurgery. Prognostic factors that allow an estimation of the risk of developing new cerebral metastases can facilitate the decision regarding additional whole-brain irradiation. Since primary tumors show a different biology and clinical course, prognostic factors should be identified separately for each primary tumor leading to brain metastasis. The present study investigated 10 characteristics in a series of 98 patients receiving radiosurgery alone for 1-2 cerebral metastases from lung cancer, the most common primary tumor associated with brain metastasis. These characteristics included radiosurgery dose, age, gender, performance status, histology, number of cerebral lesions, maximum total diameter of cerebral lesions, main location of cerebral lesions, extracranial spread and interval from first diagnosis of lung cancer to administration of radiosurgery. On univariate analysis, the number of cerebral lesions prior to radiosurgery (1 vs. 2 lesions) was the only characteristic significantly associated with freedom from new brain metastases (P=0.002). In cases of 2 lesions, 73% of patients developed new cerebral lesions within 1 year. On multivariate analysis, the number of brain metastases remained significant (risk ratio, 2.46; 95% confidence interval, 1.34-4.58; P=0.004). Given the high rates of new cerebral lesions in patients with 2 brain metastases, these patients should be strongly considered for additional whole-brain irradiation. IntroductionNumerous patients with few brain metastases receive neurosurgical resection or radiosurgery, either alone or in combination with whole-brain irradiation. As radiosurgery is similarly effective but less invasive than resection, the use of radiosurgery for the treatment of brain metastases has become more popular (1-3). Previous studies have shown that the addition of whole-brain irradiation can improve intracerebral control when compared with radiosurgery alone (4,5). As an intracerebral recurrence has been reported to be a major cause of neurocognitive deficits, the addition of whole-brain irradiation, which reduces the risk of intracerebral failure, also appears beneficial for the patients from this viewpoint (6,7). However, whole-brain irradiation itself can lead to a decline in neurocognitive function. This important treatment-related late morbidity was found to occur significantly more frequently after radiosurgery plus wholebrain irradiation than after radiosurgery alone at 4 mo...

show abstract

CyberKnife therapy of 24 multiple brain metastases from lung cancer: A case report

Cited by 4 publications

References 18 publications

Brain metastases from hepatocellular carcinoma: recent advances and future avenues

Brain metastases from hepatocellular carcinoma: recent advances and future avenues

Re-irradiation of multiple brain metastases using CyberKnife stereotactic radiotherapy

Number of cerebral lesions predicts freedom from new brain metastases after radiosurgery alone in lung cancer patients

Contact Info

Product

Resources

About