Cycle regimens for frozen-thawed embryo transfer

Abstract

Trusted evidence. Informed decisions. Better health.

Interval between IVF stimulation cycle and frozen embryo transfer: Is there a benefit to a delay between cycles?

“…There is limited published data available. Although the published studies identified on the subject differ somewhat in their conclusions, they support early FET after a stimulation cycle . Santos‐Ribiero et al .…”

“…Frozen embryo transfer is no longer seen as simply supplemental to fresh transfer and is more frequently being planned electively as evidence has accumulated of potential benefits of avoiding fresh transfer. This has been facilitated by improved cryopreservation techniques, including the use of vitrification and improved cycle preparation regimens for FET . Recognised benefits include improved implantation and pregnancy rates, and prevention of ovarian hyperstimulation syndrome …”

“…This has been facilitated by improved cryopreservation techniques, including the use of vitrification and improved cycle preparation regimens for FET . Recognised benefits include improved implantation and pregnancy rates, and prevention of ovarian hyperstimulation syndrome …”

“…There is currently little data to guide the optimal timing of FET following ovarian stimulation and they are frequently delayed to minimise the suspected residual effects of stimulation . Of particular concern is the supraphysiological concentrations of oestradiol and progesterone exposure, which are thought to impact on endometrial receptivity . However, delaying FET may be a source of patient stress and treatment discontinuation among couples who have already experienced a delay to conceiving, and thus it should be demonstrated that there is benefit to delayed FET if this is to be undertaken …”

Mimicking reproductive endocrinology to achieve successful pregnancy in frozen embryo replacement cycle in luteinized unruptured follicle (LUF

“…Currently there is insufficient evidence to support the use of one cycle regimen in preference to another in preparation for FET in sub-fertile women with regular ovulatory cycles. 3 Luteinized unruptured follicle (LUF) is considered as one of the causes of subfertility. LUF is observed in 10% of natural menstrual cycles in fertile women, but in stimulated cycles it is higher.…”