Cyclea Barbata Leaf Extract: Lipoxygenase Inhibitory Activity and Phytochemical Screening

Handayani, Nadya Febri; Elya, Berna; Puspitasari, Nuraini

doi:10.22159/ijap.2018.v10s1.22

Cited by 4 publications

(6 citation statements)

References 10 publications

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“…It was reported that flavonoids have many benefits, such as antibacterial, anti-inflammatory, anticancer, antioxidant, hepatoprotective, and antiviral properties [ 55 , 56 ]. Handayani et al reported inhibition of LOX with leaf extracts of C. Barbarata [ 57 ]. Three various solvents (ethyl acetate, n -hexane, and methanol) were employed for extraction.…”

Section: Lipoxygenase Inhibition By Plant Extracts Of Family Menismentioning

confidence: 99%

Lipoxygenase Inhibition by Plant Extracts

et al. 2021

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Lipoxygenases are widespread enzymes that catalyze oxidation of polyunsaturated fatty acids (linoleic, linolenic, and arachidonic acid) to produce hydroperoxides. Lipoxygenase reactions can be desirable, but also lipoxygenases can react in undesirable ways. Most of the products of lipoxygenase reactions are aromatic compounds that can affect food properties, especially during long-term storage. Lipoxygenase action on unsaturated fatty acids could result in off-flavor/off-odor development, causing food spoilage. In addition, lipoxygenases are present in the human body and play an important role in stimulation of inflammatory reactions. Inflammation is linked to many diseases, such as cancer, stroke, and cardiovascular and neurodegenerative diseases. This review summarized recent research on plant families and species that can inhibit lipoxygenase activity.

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Section: Lipoxygenase Inhibition By Plant Extracts Of Family Menismentioning

confidence: 99%

Lipoxygenase Inhibition by Plant Extracts

et al. 2021

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“…Berdasarkan hasil tersebut dapat dilihat bahwa efek antiinflamasi ekstrak etanol daun C. barbata dosis 7,5 mg/kgBB hampir setara dengan kontrol positif Na.Diklofenak yakni sebesar 38.43%. Penelitian lainnya dilakukan oleh Handayani et al, (2018) untuk menghambat aktivitas lipoxygenase. Persentase nilai penghambatan tertinggi ekstrak etil asetat sebesar 53.76%, sehingga diperoleh nilai IC50 0.267 µg/mL.…”

Section: Antiinflamasiunclassified

Cyclea barbata L. Miers.: Penggunaan tradisional, fitokimia, dan aktivitas farmakologi

Febrianto

Praharsini²,

Annas³

et al. 2022

SJP

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Indonesian people still favor the use of traditional medicine because they believe its side effects are lower than synthetic drugs. One of the plants that can be used in traditional medicine is Cyclea barbata L. Miers, or green grass jelly. This study aimed to explain and summarize the traditional use, phytochemical content, and pharmacological activity of C. barbata. All information on C. barbata was collected from various electronic databases (Google Scholar, Science Direct, and PubMed) using important and related keywords. Secondary metabolites found in stems, roots, and leaves are alkaloids and flavonoids. The pharmacological activities of C. barbata include antibacterial, antioxidant, anti-plasmodial, immunomodulator, Alzheimer, anti-inflammatory, anti-cholesterol, and antiulcer. Although C. barbata has been used empirically, further research is still needed to ensure the effectiveness and safety of this plant.

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“…The flavonoids have the potential to inhibit the expression of isoforms that induce nitric oxide, cyclooxygenase, and lipoxygenase, which manage the production of nitrate oxide, prostanoids, leukotrienes, and any other mediators of the inflammatory process, like cytokines and chemokines. Thus, the flavonoid compounds in Cyclea barbata leaves are thought to inhibit the formation of leukotriene, and also have an anti-inflammatory effect [10]. Handayani N.F., et al, research shows that the ethyl acetate extract from Cyclea barbata leaves the highest lipoxygenase inhibitory activity, with an IC50 of 0.267 mg/mL.…”

Section: Introductionmentioning

confidence: 99%

The percentages of chlorophyll, flavonoids, dietary fibre, and water content in cyclea barbata, premna oblongata miq, and cocculus orbiculatus leaves

Suharyo

Handayani

Wahjoerini

2023

IOP Conf. Ser.: Earth Environ. Sci.

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Some plants whose leaves can be made into green grass jelly are Cyclea barbata (Cincau rambat bulu), Premna oblongata Miq (Cincau perdu), and Cocculus orbiculatus (Cincau jelly). However, the percentage of the content contained in each plant leaf is not necessarily the same. This study aims to determine the percentage of chlorophyll, flavonoids, dietary fibre, and water content from these three fresh leaves planted by researchers in Semarang. The analysis of chlorophyll content using spectrophotometry method with a 663 nm and 645 nm wavelength. The analysis of flavonoid content using the spectrophotometry method with a 420 nm wavelength. The study of dietary fibre content using the multienzyme method. And the analysis of water content using the heating method. Cyclea barbata leaves have the highest chlorophyll (9.806%) and flavonoids (0.1054%) content of all, while Premna oblongata Miq leaves have the highest water content (79.3370%) and dietary fibre (12.5125%) content of all.

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Cyclea Barbata Leaf Extract: Lipoxygenase Inhibitory Activity and Phytochemical Screening

Cited by 4 publications

References 10 publications

Lipoxygenase Inhibition by Plant Extracts

Lipoxygenase Inhibition by Plant Extracts

Cyclea barbata L. Miers.: Penggunaan tradisional, fitokimia, dan aktivitas farmakologi

The percentages of chlorophyll, flavonoids, dietary fibre, and water content in cyclea barbata, premna oblongata miq, and cocculus orbiculatus leaves

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