Advances in Experimental Medicine and Biology

1980

DOI: 10.1007/978-1-4684-3632-7_14

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Cyclic Amp And ß-Adrenergic Receptors during The Development Of Physical Dependence On Ethanol In The Rat

Ronald G. Thurman¹,

T. Kendall Harden²,

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1983

1983

1999

1999

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Cited by 4 publications

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Physico-Chemical Interactions between Alcohol and Biological Membranes

¹

,

²

1983

Research Advances in Alcohol and Drug Problems

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Physico-Chemical Interactions between Alcohol and Biological Membranes

¹

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²

1983

Research Advances in Alcohol and Drug Problems

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Coupling efficiency of brain β -adrenergic receptors to G s protein in suicide, alcoholism and control subjects

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²

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³

et al. 1999

Psychopharmacology

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Abnormal beta-adrenergic receptor (betaAR) density in the brains of suicide victims has been reported, although results of studies are inconsistent. Ethanol modifies betaAR-mediated signal transduction. Moreover abnormal betaAR function has been implicated in alcoholism. BetaAR antagonists, which were used as ligands in previous betaAR binding studies, also bind to 5-HT1B/1Dbeta receptors; hence, their estimates of betaAR density are confounded by binding to 5-HT1B/1Dbeta receptors. More importantly, previous studies did not examine betaAR agonist affinity or coupling efficiency to Gs protein. We investigated agonist affinity and coupling efficiency of betaAR to Gs protein in the brains of ten suicide victims, six subjects with alcoholism, and eight controls. There were no differences in betaAR density in either the frontal cortex or hippocampus of suicide victims or alcoholic subjects compared to controls. Preliminary results indicate betaAR supercoupling in suicide victims in both brain regions and uncoupling in alcoholic subjects in the frontal cortex. These results are discussed in view of the existing literature on the role of betaAR in suicide and alcoholism and the mechanism of action of antidepressants.

The combined effects of chronic ethanol/desipramine treatment on β-adrenoceptor density and coupling efficiency in rat brain

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²

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³

et al. 1998

European Journal of Pharmacology

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