Cyclic AMP is decreased in mononuclear leukocytes from psoriasis patients

Geerdink, J.P.M.; Bergers, Mieke; Erp, P.E.J. van; Gommans, J.M.; Mier, P.D.; Roelfzema, H.

doi:10.1111/j.1365-2133.1980.tb15847.x

Cited by 11 publications

(6 citation statements)

References 6 publications

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“…We found that in the same, highly purified cells assessed for monocyte and neutrophil cytotoxicity, the content of cyclic nucleotides was the same in the psoriatics as in normals. Recently, it has been stressed that monocytes from psoriatics have decreased cAMP content (Geerdink et al, 1980) supporting the suggestions of Bar-Eli et al (1979). However, Geerdink et al (1980) investigated mononuclear leukocjrtes containing only 30% monoc)rtes.…”

Section: Discussionsupporting

confidence: 73%

“…Recently, it has been stressed that monocytes from psoriatics have decreased cAMP content (Geerdink et al, 1980) supporting the suggestions of Bar-Eli et al (1979). However, Geerdink et al (1980) investigated mononuclear leukocjrtes containing only 30% monoc)rtes. The decreased cAMP level was therefore possibly confined to the contaminating lymphocytes as reported by others (Harpaz et al, 1980).…”

Section: Discussionsupporting

confidence: 73%

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Enhanced monocyte and neutrophil cytotoxicity and normal cyclic nucleotide levels in severe psoriasis

Herlin

Kragballe

1981

British Journal of Dermatology

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Eighteen patients with active psoriasis were investigated for antibody-dependent cell-mediated cytotoxicity (ADCC) mediated by monocytes and neutrophil leukocytes. Patients with extensive psoriatic lesions showed increased ADCC whereas patients with minimal psoriasis had normal monocyte and neutrophil function. After clinical remission the ADCC became normal. No stimulatory factors in psoriatic serum could be demonstrated. The increased monocyte and neutrophil cytotoxicity in severe psoriasis is not explained by altered cyclic nucleotide levels as cAMP and cGMP levels were normal in psoriatic monocytes and neutrophils showing both increased and normal ADCC. Our results indicate that increased ADCC is secondary to the psoriatic activity.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionsupporting

confidence: 73%

Enhanced monocyte and neutrophil cytotoxicity and normal cyclic nucleotide levels in severe psoriasis

Herlin

Kragballe

1981

British Journal of Dermatology

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“…Firstly, the increased activity of the hexose monophosphate shunt found in erythrocy tes in psoriasis (Holzmann & Morsches, 1970) is in keeping with the higher respiratory burst activity found in our experiments. Secondly, the decreased amount of the cyclic nucleotide cAMP as found in psoriatic monocytes (Geerdink et al, 1980) correlates well with the fact that by lowering the cAMP/cGMP ratio in phagocytes an enhanced phagocytic response ensues (Stossel et al, 1972). In addition, it was found that cyclic AMP decreases superoxide generation in phagocytes (Lohmeyer & Johnston, 1978).…”

Section: Discussionmentioning

confidence: 76%

Increased respiratory burst activity of monocytes and polymorphonuclear leukocytes in psoriasis

1982

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We studied the respiratory burst activity of peripheral blood monocytes and polymorphonuclear leukocytes (PMN) in eleven patients with psoriasis and eleven healthy controls, using zymosan particles to activate the phagocytes in vitro. The activation of the phagocytes was measured in a luminol-enhanced chiluminescence (CL) assay. We found a significantly higher respiratory burst activity of both monocytes and PMN in patients with psoriasis compared with the control subjects. The percentages of monocytes in psoriatics did not differ from those of the controls. The higher amount of zymosan-induced CL activity generated in the patient group was unrelated to the age of the individual. Our data indicate increased metabolic reactivity of both monocytes and PMN in psoriasis.

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“…These findings are in keeping with those of Krueger et al (1978), who demonstrated increased chemotactic activity in monocytes from disease-free psoriatic patients compared with those from normal subjects, and that this difference was enhanced after activation of the sera by zymosan. In contrast, many other abnormalities previously observed in monocytes from psoriatic patients, such as decreased cyclic AMP (Geerdink et al, 1980), increased chcmiluminescencc (Krueger & Jederberg, 1979) and increased respiratory burst activity (Schopf, Altmayer & Lemmel, 1982) occur only in active disease but not in quiescent psoriasis (Geerdink et al, 1984).…”

Section: Psoriatic Subjectsmentioning

confidence: 89%

The sequence of events in psoriatic plaque formation after tape-stripping

Heng¹,

Kloss²,

Kuehn³

et al. 2006

British Journal of Dermatology

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The sequence of events leading to the formation of a psoriatic plaque induced by tape-stripping was studied using light and electron microscopy. Among the earliest changes noted were increased mobility of the epidermal Langerhans cells across the basement membrane, evidence of Langerhans cell-lymphocyte interaction, and increased Langerhans cell 'activity' or 'cytotoxicity'. These changes were seen as early as 2 min after stripping and remained until the development of clinical psoriasis. Collections of epidermal lymphocytes showing the features of blastoid transformation while in contact with processes from activated Langerhans cells, suggest the involvement of la antigens in this process. We postulate that these findings are a manifestation of an increased immune responsiveness to trauma, controlled by genes located at the HLA-D locus of the major histoeompatibility complex, and mediated by enhanced cellular interactions. The appearance of basal keratinocyte herniations (BKH) at 1-3 weeks after stripping, coincided with the development of clinical psoriasis. Neutrophils made their appearance at the same time as, or slightly before, the appearance of BKH, and are suspected to play a role in the development of these structures. We believe that BKH maintain epidermal proliferation through the persistence of the epidermal-stromal interaction.

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Cyclic AMP is decreased in mononuclear leukocytes from psoriasis patients

Cited by 11 publications

References 6 publications

Enhanced monocyte and neutrophil cytotoxicity and normal cyclic nucleotide levels in severe psoriasis

Enhanced monocyte and neutrophil cytotoxicity and normal cyclic nucleotide levels in severe psoriasis

Increased respiratory burst activity of monocytes and polymorphonuclear leukocytes in psoriasis

The sequence of events in psoriatic plaque formation after tape-stripping

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