Cyclic Block Copolymer Microchannel Fabrication and Sealing for Microfluidics Applications

Yen, Chia Yi; Chang, Moh Ching O.; Shih, Zong Fu; Lien, Yi Hsing; Tsao, Chia Wen

doi:10.3390/inventions3030049

Cited by 9 publications

(6 citation statements)

References 36 publications

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“…[ 171 ] Thermal bonding of COC has been widely reported in the literature. [ 172–179 ] When using the same material for thermal bonding, the microchannel exhibits homogeneous surface properties and higher bonding strength. Spigarelli et al.…”

Section: Bondingmentioning

confidence: 99%

A Review of Cyclic Olefin Copolymer Applications in Microfluidics and Microdevices

Agha

Waheed

Alamoodi

et al. 2022

Macro Materials & Eng

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Cyclic olefin copolymers (COC) are amorphous, transparent thermoplastics composed of cyclic olefin monomers (norbornene) and linear olefins (ethene). They are increasingly utilized as fabrication materials for microsystems and microfluidic devices, owing to their promising features of low water absorption, high electrical insulation, long-term stability of surface treatments, and resistance to a broad variety of acids and solvents. Many manufacturing processes for COC-based devices have been developed in recent decades. These methodologies are categorized as replication methods or fast prototyping as common in fabrication of thermoplastic microfluidic devices. This review gives a full discussion of the features of COCs, the various production processes, and the numerous selected applications in microfluidic platforms. The review also explores COC's composition and fundamental features, as well as fabrication processes and applications in a variety of fields, investigates the material's potential advantages and uses, and attempts to create a comprehensive list of COC's possible benefits. Due to their unique features and simplicity of fabrication, COCs are projected to advance the future of microfluidics, microsystems, and optofluidics.

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Section: Bondingmentioning

confidence: 99%

A Review of Cyclic Olefin Copolymer Applications in Microfluidics and Microdevices

Agha

Waheed

Alamoodi

et al. 2022

Macro Materials & Eng

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“…After total hydrogenation of the CC and benzene ring, the obtained product CBC (cyclic block copolymer) has the advantages of low density, high transparency, high UV penetration, high heat/oxidation/UV resistance, low water absorption, etc. CBC has been widely used in optics, medical treatment, biomedical detection, and other fields. − …”

Section: Catalytic Hydrogenation Of Unsaturated Polymersmentioning

confidence: 99%

Advances in the Catalytic Hydrogenation and Properties of Unsaturated Polymers

Yan

Cao

2023

Macromolecules

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Polymer reaction and performance improvement are one of the important contents in the field of polymer materials science and engineering, in which polymer catalytic hydrogenation is an important part of polymer reaction. We reviewed the research achievements on polymer hydrogenation over the past 70 years and studied the mechanism of the hydrogenation reaction from the aspects of performance changes before and after polymer hydrogenation, the catalyst preparation/structure−activity relationship, and polymer hydrogenation kinetics. We pointed out the difficulty in separation and unsatisfactory high-temperature adaptability of traditional homogeneous catalysts and first proposed four effects affecting traditional heterogeneous polymer hydrogenation: scale effect, conformation effect, viscosity effect, and adhesion effect. Based on the structure−activity relationship of polymers, we put forward the application direction of hydrogenated polymers at present. We found that using a new kind of nanometal catalyst (Pd/CNTs@FN) as hydrogenation catalyst can effectively reduce or eliminate the negative effects of these four effects on the polymer hydrogenation reaction, and it is easy to separate from the reaction system. The addition of CNTs can effectively increase the specific surface area of the catalyst and strengthen the interaction between reactants and catalyst. Subsequent research should focus on designing the multiscale structure and improving low-temperature activity of the catalyst, reducing process cost, and using green and efficient separation methods to eliminate adverse effects, create a green and efficient polymer reaction system, accelerate the industrialization of polymer hydrogenation process, and provide theoretical guidance for the research and development of new polymer materials.

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“…The two PMMA substrates exposed briefly to an oxygen plasma were assembled by thermal bonding, at a temperature close to T g (i.e., 108 °C) and under a pressure of 100 bar [ 42 ]. UV treatment before thermal bonding has been shown to achieve an increase in bonding strength and reduced bonding temperature [ 34 , 43 , 44 ]. O 2 plasma and ethanol treatment prior to thermal bonding has been explored as an alternative to conventional O 2 -plasma-assisted thermal bonding to reduce the distortion of nanochannels [ 45 ].…”

Section: Direct Bondingmentioning

confidence: 99%

Recent Advances in Thermoplastic Microfluidic Bonding

Giri

Tsao

2022

Micromachines

Self Cite

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Microfluidics is a multidisciplinary technology with applications in various fields, such as biomedical, energy, chemicals and environment. Thermoplastic is one of the most prominent materials for polymer microfluidics. Properties such as good mechanical rigidity, organic solvent resistivity, acid/base resistivity, and low water absorbance make thermoplastics suitable for various microfluidic applications. However, bonding of thermoplastics has always been challenging because of a wide range of bonding methods and requirements. This review paper summarizes the current bonding processes being practiced for the fabrication of thermoplastic microfluidic devices, and provides a comparison between the different bonding strategies to assist researchers in finding appropriate bonding methods for microfluidic device assembly.

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Cyclic Block Copolymer Microchannel Fabrication and Sealing for Microfluidics Applications

Cited by 9 publications

References 36 publications

A Review of Cyclic Olefin Copolymer Applications in Microfluidics and Microdevices

A Review of Cyclic Olefin Copolymer Applications in Microfluidics and Microdevices

Advances in the Catalytic Hydrogenation and Properties of Unsaturated Polymers

Recent Advances in Thermoplastic Microfluidic Bonding

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