Cyclic neutropenia

The role of gram-negative bacteria in the pathogenesis of necrotizing enterocolitis has been stressed. We describe a 21-year-old woman with chronic neutropenia with cyclic fluctuations who died of necrotizing enterocolitis due to Clostridium septicum. Seven patients with cyclic neutropenia and necrotizing enterocolitis have been described in the literature and in each case in which bacteriologic data were reported, a Clostridial infection was documented. Patients with cyclic neutropenia should be treated with antibiotics effective against Clostridial species when abdominal symptoms complicate neutropenic periods.

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Clostridial species in the pathogenesis of necrotizing enterocolitis in patients with neutropenia

Hopkins

Kushner

1983

American J Hematol

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Derzeitiger Stand der Synchronisationstherapie von malignen Tumoren und akuten Leuk�mien

Sauer

Wilmanns

1976

Klin Wochenschr

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Chemotherapy of malignant tumors can be made more effective by synchronization of the cell cycle. Synchronization therapy consists of a synchronizing step (phase I), an interval and a cytocidal step (phase II). Some regimens till now approved in clinical treatment are presented. The results are found to be encouraging. In all schedules three effects work together namely synchronization recruitment, summation.

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The Severe Chronic Neutropenia International Registry: 10-Year Follow-up Report

Dale

Bolyard

Schwinzer

et al. 2006

Supportive Cancer Therapy

142

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Cyclic neutropenia

Cited by 3 publications

References 4 publications

Clostridial species in the pathogenesis of necrotizing enterocolitis in patients with neutropenia

Clostridial species in the pathogenesis of necrotizing enterocolitis in patients with neutropenia

Derzeitiger Stand der Synchronisationstherapie von malignen Tumoren und akuten Leuk�mien

The Severe Chronic Neutropenia International Registry: 10-Year Follow-up Report

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