Cyclic voltammetry study of glucose and insulin interactions with supported lipid membrane

Laputková, Galina; Sabó, Ján

doi:10.1016/s1567-5394(02)00044-0

Cited by 5 publications

(6 citation statements)

References 11 publications

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“…We found evidence that glucose influences the properties of s-BLM's in physiologically relevant concentrations. But we also observed that the influence of the glucose is different if s-BLM's are modified with anthraquinone-2-sulphonic acid [4], where the membrane current was reduced after the glucose application reached 10 mmol.l -1 .…”

Section: Discussionmentioning

confidence: 67%

Influence of D-Glucose on Lipid Solid Support Membrane System as Attempt for Biosensing of Medically Relevant Molecules

Laputková

Legin²,

Sabó³

2004

Acta Med. (Hradec Kralove, Czech Repub.)

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The influence of D-glucose on a lipid solid support system with the aid of impedance spectrocopy as a preliminary attempt for the biosensing of medical relevant molecules was studied. In spite of some shortcomings, s-BLM's proved to be an appropriate model for the study of lipid membrane – D-glucose interactions. The shortcomings were the roughness of the metal support, and the lack of homogeneity in the monolayer or multilayer lipid structures.

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Section: Discussionmentioning

confidence: 67%

Influence of D-Glucose on Lipid Solid Support Membrane System as Attempt for Biosensing of Medically Relevant Molecules

Laputková

Legin²,

Sabó³

2004

Acta Med. (Hradec Kralove, Czech Repub.)

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“…Laputkova et al . reported both the oxidation and the reduction current peaks of potassium ferricyanide were decreasing at the presence of glucose in concentration range from 10 to 320 mM by means of cyclic voltammetry (CV) [ 53 ]. In conclusion, the concentration of cell affected the current peak, whereas, the type of the cell affected the peak potentials.…”

Section: Discussionmentioning

confidence: 99%

Detection and Identification of Hematologic Malignancies and Solid Tumors by an Electrochemical Technique

Wang

Zhang

et al. 2016

PLoS ONE

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PurposeDevelop and evaluate an electrochemical method to identify healthy individuals, malignant hematopathic patients and solid tumor patients by detecting the leukocytes in whole-blood.MethodsA total of 114 individual blood samples obtained from our affiliated hospital in China (June 2015- August 2015) were divided into three groups: healthy individuals (n = 35), hematologic malignancies (n = 41) and solid tumors (n = 38). An electrochemical workstation system was used to measure differential pulse voltammetry due to the different electrochemical behaviors of leukocytes in blood samples. Then, one-way analysis of variance (ANOVA) was applied to analyze the scanning curves and to compare the peak potential and peak current.ResultsThe scanning curve demonstrated the specific electrochemical behaviors of the blank potassium ferricyanide solution and that mixed with blood samples in different groups. Significant differences in mean peak potentials of mixture and shifts (ΔEp (mV)) were observed of the three groups (P< = 0.001). 106.00±9.00 and 3.14±7.48 for Group healthy individuals, 120.90±11.18 and 18.10±8.81 for Group hematologic malignancies, 136.84±11.53 and 32.89±10.50 for Group solid tumors, respectively. In contrast, there were no significant differences in the peak currents and shifts.ConclusionsThe newly developed method to apply the electrochemical workstation system to identify hematologic malignancies and solid tumors with good sensitivity and specificity might be effective, suggesting a potential utility in clinical application.

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“…It has been shown, that both the oxidation and the reduction current peaks decreased at the presence of glucose in concentration range varying from 10 to 320 mmol L −1 . The pretreatment of membrane with physiological concentration of insulin (0.13 nmol L −1 ) evoked slight increase of the sBLM conductance at presence of glucose 104.…”

Section: Biosensors Based On Supported Lipid Films In Electroanalysismentioning

confidence: 95%

Stabilized Lipid Films in Electrochemical Biosensors

2010

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Lipid membrane based electrochemical biosensors have been exploited for the last 40 years. However, a major obstacle that limited their applications and commercialization was their fragility. Recent advances in stabilization of lipid membranes have tremendously increased the number of publications in the last 5 years. The objective of the present article is to present procedures for the stabilization of lipid film biosensors and recent advances in their analytical uses. These novel devices are used as chemo-and biosensors for the quantification of environmental contaminants and food toxicants. Recent research is directed to the construction of a portable mini electrochemical device that will be commercialized and readily be used by non-skilled personnel for in the field measurements.

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Cyclic voltammetry study of glucose and insulin interactions with supported lipid membrane

Cited by 5 publications

References 11 publications

Influence of D-Glucose on Lipid Solid Support Membrane System as Attempt for Biosensing of Medically Relevant Molecules

Influence of D-Glucose on Lipid Solid Support Membrane System as Attempt for Biosensing of Medically Relevant Molecules

Detection and Identification of Hematologic Malignancies and Solid Tumors by an Electrochemical Technique

Stabilized Lipid Films in Electrochemical Biosensors

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