Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

Evans, Tom; Rosenthal, Eric T.; Youngblom, Jim; Distel, Daniel L.; Hunt, Tim

doi:10.1016/0092-8674(83)90420-8

Cited by 1,364 publications

(721 citation statements)

References 30 publications

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“…The latter observation ignored the cytogenetic and metabolic patterns observed by Hansemann and Warburg, respectively, in tumor tissues, perhaps because of the scarcity of available knowledge. The correct number of human chromosomes was determined only in the 1950s (Tijo and Levan, 1956); normal cells were believed to be immortal (Carrel and Ebeling, 1921); and cyclins, proteins responsible for controlling cell-cycle progression, were discovered only in 1982s (Evans et al, 1983).…”

Section: The Warburg Effectmentioning

confidence: 99%

Metabolic reprogramming of the tumor

2012

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Cancer is classically considered as a genetic and, more recently, epigenetic multistep disease. Despite seminal studies in the 1920s by Warburg showing a characteristic metabolic pattern for tumors, cancer bioenergetics has often been relegated to the backwaters of cancer biology. This review aims to provide a historical account on cancer metabolism research, and to try to integrate and systematize the metabolic strategies in which cancer cells engage to overcome selective pressures during their inception and evolution. Implications of this renovated view on some common concepts and in therapeutics are also discussed.

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Section: The Warburg Effectmentioning

confidence: 99%

Metabolic reprogramming of the tumor

2012

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“…The tightly regulated progression through the cell cycle is brought about by periodic activation of cyclin and cyclindependent kinases (CDKs). The independent discoveries of cyclins in sea urchin oocytes, along with the simultaneous identification of maturation-promoting factors in frog oocytes and of CDC proteins in Saccharomyces cerevisiae, converged to give rise to the present-day concepts of cyclin-CDK complexes (Hartwell et al, 1970;Masui and Markert, 1971;Evans et al, 1983). The seminal discovery of cyclin/CDK complexes is believed to be at the core of understanding cellular proliferation controls.…”

Section: Intracellular Redox State and Cell Cycle Proteinsmentioning

confidence: 99%

A redox cycle within the cell cycle: ring in the old with the new

2006

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In recent years, the intracellular oxidation-reduction (redox) state has gained increasing attention as a critical mediator of cell signaling, gene expression changes and proliferation. This review discusses the evidence for a redox cycle (i.e., fluctuation in the cellular redox state) regulating the cell cycle. The presence of redox-sensitive motifs (cysteine residues, metal co-factors in kinases and phosphatases) in several cell cycle regulatory proteins indicate periodic oscillations in intracellular redox state could play a central role in regulating progression from G 0 /G 1 to S to G 2 and M cell cycle phases. Fluctuations in the intracellular redox state during cell cycle progression could represent a fundamental mechanism linking oxidative metabolic processes to cell cycle regulatory processes. Proliferative disorders are central to a variety of human pathophysiological conditions thought to involve oxidative stress. Therefore, a more complete understanding of redox control of the cell cycle could provide a biochemical rationale for manipulating aberrant cell proliferation.

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“…The concentration of cyclin B increases steadily from late S phase up to its peak at the phase transition point from G 2 to M, whereas the level of p34 cdc2 remains relatively constant throughout the cell cycle [5], [6]. The modulation of cyclin concentration by synthesis and degradation is of special importance for the control of MPF (maturation/M-phase promoting factor) activity [7].…”

Section: Introductionmentioning

confidence: 99%

A novel ubiquitin carboxyl terminal hydrolase is involved in toad oocyte maturation

et al. 2002

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ABSTRACTp28, a 28kD protein from toad (Bufo bufo gargarizans) oocytes, was identified by using p13 suc1 -agarose affinity chromatography. Sequence homology analysis of the full-length cDNA of p28(Gene Bank accession number: AF 314091) indicated that it encodes a protein containing 224 amino-acids with about 55% identities and more than 70% positives to human, rat or mouse UCH-L1, and contains homological functional domains of UCH family. Anti-p28 monoclonal antibody, on injecting into the oocytes, could inhibit the progesterone-induced resumption of meiotic division in a dose-dependent manner. The recombinant protein p28 showed similar SDS/PAGE behaviors to the native one, and promoted ubiquitin ethyl ester hydrolysis, a classical catalytic reaction for ubiquitin carboxyl terminal hydrolases (UCHs). The results in this paper reveal that a novel protein, p28, exists in the toad oocytes, is a UCH L1 homolog, was engaged in the process of progesterone-induced oocyte maturation possibly through an involvement in protein turnover and degradation.

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Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

Cited by 1,364 publications

References 30 publications

Metabolic reprogramming of the tumor

Metabolic reprogramming of the tumor

A redox cycle within the cell cycle: ring in the old with the new

A novel ubiquitin carboxyl terminal hydrolase is involved in toad oocyte maturation

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