Cyclin D1 Expression and Its Correlation with Histopathological Differentiation in Oral Squamous Cell Carcinoma

Abstract

Background. Cyclin D1 regulates the G1 to S transition of cell cycle. Its deregulation or overexpression may lead to disturbance in the normal cell cycle control and tumour formation. Overexpression of cyclin D1 has been reported in various tumors of diverse histogenesis. This case control retrospective study was carried out to study the immunohistochemical reactivity and expression of cyclin D1 and its association with site, clinical staging, and histopathological differentiation of oral squamous cell carcinoma (OSCC). Methods. Forty formalin-fixed paraffin-embedded tissue blocks of biopsy specimens of oral squamous cell carcinoma were immunohistochemically evaluated for expression of cyclin D1. Results. Cyclin D1 expression was seen in 45% cases of OSCC. It did not correlate with site and clinical staging. Highest expression was seen in well-differentiated, followed by moderately differentiated, and poorly differentiated squamous cell carcinomas, with a statistically significant correlation. Conclusion. Cyclin D1 expression significantly increases with increase in differentiation.

Role of E-cadherin and cyclin D1 as predictive markers of aggression and clonal expansion in head and neck squamous cell carcinoma

“…In our study we did not find a statistically significant association ( P =0.081) although we noted that 68.4% of early-stage tumours did not show cyclin D1 overexpression. No significant association was noted with tumour grade, which is in agreement with previous studies2842, although there are a few reports of a significant correlation between tumour grade and cyclin D1 overexpression2941444546.…”

Cyclin D1 expression in Bowen’s disease and cutaneous squamous cell carcinoma

“…Additionally, the expression of cyclin D1 in SCC was higher compared to that in BD and the control groups (P<0.05). Huang et al (25) reported a marked overexpression of cyclin D1 in cutaneous SCC compared to that in normal skin, which is in line with the data reported for several other malignancies, including head and neck SCC (3) and oropharyngeal SCC (16), including a large number of samples. The prognostic value of cyclin D1 has been described in detail for tumor entities in these experiments.…”

“…However, whether cyclin D1 expression correlates with histopathological differentiation in tumors remains controversial. Saawarn et al (16) observed that there was an increase in cyclin D1 expression with increasing histological differentiation in oral SCC. However, Liang et al (14) reported that the expression of cyclin D1 was markedly increased from normal skin through dysplasia to BD, but was not significantly correlated with the degree of SCC differentiation.…”

“…The overexpression of cyclin D1 leads to shortening of the G1 phase and increases independence from growth factors and abnormal cell proliferation, which may foster the occurrence of additional genetic alterations (4,5). This induction of proliferation by cyclin D1, which is due to gene amplification, was previously identified in different types of human malignant tumors, including cancer of the breast (6), esophagus (7), liver (8), head and neck (3), lung (9), larynx (10), bladder (11), uterus (12), lymphoid tissue (13), melanoma (14,15) and oral SCC (4,16). Cyclin D1 has been considered to be an oncogene and it is hypothesized that it plays a significant role in the neoplastic transformation of certain tumors (14).…”

Prognostic and Predictive Values of cell Cycle Proteins Centrosomal Protein 5 (CEPP 5)

“…The final SI was ranged from 0 to 12, and optimal SI cutoff value 6 were chosen and we used SI of ≥ 6 to define tumors with CEP55 over expression, and a score of ≤ 6 to define tumors with low expression [14]. The final SI was ranged from 0 to 12, and optimal SI cutoff value 4 were chosen and we used SI of ≥ 4 to define tumors with Cyclin D1 over expression, and a score of ≤ 4 to define tumors with low expression [15].…”