Cyclization of 4-(2-Aminoanilino)-2-Benzylthiopyrimidine to Novel 1-(2-Benzylthiopyrimidin-4-Yi)-2-Substituted Benzimidazoles

Basha, N. Jeelan; Reddy, CH Upendar; Goudgaon, Ν. M.

doi:10.1515/hc.2008.14.6.469

Cited by 11 publications

(5 citation statements)

References 4 publications

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“…Literature evidence the design, synthesis, and development of large‐scale antiviral drugs. Further, most of the antivirals belong to the class of pyrimidines, fused pyrimidines, and their nucleoside analogs [146,147] . Like safe vaccine development, there are challenges for antiviral drugs like low bioavailability, toxicity, and non‐specificity [148–150] .…”

Section: Scope For Present Antiviral Drugs and Challengesmentioning

confidence: 99%

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Synthesis and Antiviral Efficacy of Pyrimidine Analogs Targeting Viral Pathways

Basha¹,

Chandana²

2023

ChemistrySelect

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To date, viruses are known to cause chronic to acute pathogenesis. Nevertheless, antiviral drugs have been known for their medicinal applications for the last few decades to treat infections caused by these pathogens. Despite advancements in the field of vaccination and antiviral drugs, there is a need for a molecule that can eradicate or control viral infection without getting resistance from pathogens will be a real challenge. This review covers possible ways to treat viral infections with pyrimidine and its mimics compared to known antiviral drugs. A comprehensive study of the report accomplished synthetic routes of pyrimidine analogs and their target‐specific antiviral potential. The present review article covers literature from 2018 to 2022.

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Section: Scope For Present Antiviral Drugs and Challengesmentioning

confidence: 99%

“…Further, most of the antivirals belong to the class of pyrimidines, fused pyrimidines, and their nucleoside analogs. [146,147] Scheme 4. Pyrimidine analogs synthesized based on the importance of 5-iodox uridine, a potent antiviral agent…”

Section: Scope For Present Antiviral Drugs and Challengesmentioning

confidence: 99%

Synthesis and Antiviral Efficacy of Pyrimidine Analogs Targeting Viral Pathways

Basha¹,

Chandana²

2023

ChemistrySelect

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“…Second-line drugs that have been reported are Liu et al [163] used virtual high-throughput screening, in vitro assay, and synthesized 1-(2-chloro-6-fluorobenzyl)-2,5-dimethyl-4-((phenethylamino)methyl)-1H-pyrrole-3-carboxylate (92) as anti-tubercular agents that inhibit ClpP1P2 peptidase in M. tuberculosis. Many nitrogen-containing heterocyclic compounds were designed, synthesized, and screened for their biological activities [164,165]. However, pyrrole and pyrrolidine analogs have been attracted more for their diverse pharmacological activities [166].…”

Section: Antimycobacterial Agentsmentioning

confidence: 99%

Therapeutic potential of pyrrole and pyrrolidine analogs: an update

Basha¹,

Basavarajaiah²,

Shyamsunder³

2022

Mol Divers

102

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The chemistry of nitrogen-containing heterocyclic compound pyrrole and pyrrolidine has been a versatile field of study for a long time for its diverse biological and medicinal importance . Biomolecules such as chlorophyll, hemoglobin, myoglobin, and cytochrome are naturally occurring metal complexes of pyrrole. These metal complexes play a vital role in a living system like photosynthesis, oxygen carrier, as well storage, and redox cycling reactions. Apart from this, many medicinal drugs are derived from either pyrrole, pyrrolidine, or by its fused analogs. This review mainly focuses on the therapeutic potential of pyrrole, pyrrolidine, and its fused analogs, more specifically anticancer, anti-inflammatory, antiviral, and antituberculosis. Further, this review summarizes more recent reports on the pyrrole, pyrrolidine analogs, and their biological potential. Graphical Abstract

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“…Whereas-other nitrogen and sulfurcontaining 5-membered heterocycles like thiazolidinone are also known for their diverse biological activities [7][8][9]. In continuation of our research work on isolation and synthesis of potent molecules derived from either natural products or by synthetic route [10][11][12][13] and also because of a literature survey on the importance of pyrimidine-bearing thiazolidinone [14], here in reporting synthesis and antimicrobial activity of (5-phenylselenanyl-2-benzylthio-pyrimidin-4-yl) thiazolidin-4-one analogs 4 (a, b).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Antimicrobial Activity, and Drug-likeness profiles of 5-Phenylselenanyl-2-benzylthiopyrimidine Analogs

Basha¹

2023

Preprint

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Given literature findings on the biological importance of pyrimidine and thiazolidine, we herein report synthesis and antimicrobial activity of 5-phenylselenanyl-2-benzylthio- pyrimidin-4-yl) thiazolidine-4-one analogs 4(a, b). Compound 5-phenylselenenyl-4-hydrazino-2-benzylthiopyrimidines (2) on condensation with substituted aromatic aldehydes afforded the corresponding Schiff bases 5-phenylselenenyl-4-(substituted benzylidenehydrazino)-2-benzylthiopyrimidine 3(a-c). Finally, the cyclization of compounds 3(a-c) with thioglycolic acid in benzene as solvent yielded target compounds 4(a, b). The structures of synthesized compounds were characterized by spectral studies such as IR, 1H-NMR, and Mass spectra. Results obtained by screening these synthesized compounds for antimicrobial activity reveal that only 1, 2, 3a, 3b, and 4a exhibited good antibacterial activity against P. aeruginosa compared to the standard drug gentamycin. Among all pyrimidine analogs, compound 4b has shown good antifungal activity against the fungal strain A. niger and A. terreus. Other compounds have shown moderate to poor antifungal activity when compared with fluconazole. Also, ADMET properties were studied for synthesized compounds.

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Cyclization of 4-(2-Aminoanilino)-2-Benzylthiopyrimidine to Novel 1-(2-Benzylthiopyrimidin-4-Yi)-2-Substituted Benzimidazoles

Cited by 11 publications

References 4 publications

Synthesis and Antiviral Efficacy of Pyrimidine Analogs Targeting Viral Pathways

Synthesis and Antiviral Efficacy of Pyrimidine Analogs Targeting Viral Pathways

Therapeutic potential of pyrrole and pyrrolidine analogs: an update

Synthesis, Antimicrobial Activity, and Drug-likeness profiles of 5-Phenylselenanyl-2-benzylthiopyrimidine Analogs

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