Cycloartane glycosides from Astragalus gombo

Maamria, Leyla; Long, Christophe; Haba, Hamada; Lavaud, Catherine; Cannac, Audrey; Benkhaled, Mohammed

doi:10.1016/j.phytol.2015.01.014

Cited by 10 publications

(4 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous phytochemical investigations on Astragalus genus revealed the presence of saponins, polysaccharides, phenolics and alkaloids. [2][3][4][5] In continuation of on-going studies on the constituents of Astragalus species, [6][7][8] a phytochemical study on Astragalus monspessulanus L. was realized.…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and antioxidant activity of Astragalus monspessulanus L. growing in semiarid areas of Algeria

et al. 2018

Self Cite

View full text Add to dashboard Cite

This paper reports a phytochemical study of the aerial parts of Astragalus monspessulanus L. growing in Algeria. It deals with the isolation and structure elucidation of 13 known compounds. From the n-butanol extract, seven flavonoids 1-7, two saponins and one lignan were isolated. In addition, two phytosterols and one triterpenoid were isolated from the ethyl acetate extract. The structures of all the isolated products were determined by using 1D and 2D-NMR techniques, measurement of optical rotation, mass spectrometry ESI-MS and by comparison with literature data. Furthermore, the antioxidant activity of the n-butanol extract of the aerial parts of Astragalus monspessulanus L. was investigated using the DPPH radical scavenging and ferrous ion chelating assays. The n-butanol extract showed low (EC 50 = 2.09±0.434 mg mL -1 ) to moderate (IC 50 = 63.60±0.01 μg mL -1 ) antioxidant activities depending on the test method.

show abstract

Section: Introductionmentioning

confidence: 99%

Chemical composition and antioxidant activity of Astragalus monspessulanus L. growing in semiarid areas of Algeria

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…Te number of B. coagulans (also known as Weizmannia coagulans) [26] cells increased to 1.3 × 10 8 CFU/g. Trace elements and polysaccharides produced during the fermentation process of Astragalus [27,28] Probiotics, in an appropriate ratio, can exert synergistic efects on fermentation substrates [29]. A single strain may ofer an incomplete enzyme system, imposing certain limitations on the transformation of fermentation substrates.…”

Section: Discussionmentioning

confidence: 99%

Synergistic Impact of Lactobacillus plantarum and Bacillus coagulans on Solid-State Fermentation of Astragalus and Effects of Fermentation Products on Disease Resistance of Crucian Carp (Carassius auratus)

Shi

Xue

et al. 2023

Aquaculture Research

View full text Add to dashboard Cite

Dietary supplementation with fermentation products of Astragalus can enhance the immune function of aquaculture animals. We explored the synergistic effects of Lactobacillus plantarum and Bacillus coagulans on the solid-state fermentation of Astragalus to investigate whether feeding fermentation products to crucian carp can improve disease resistance. The optimal ratio of Astragalus + (L. plantarum + B. coagulans) (ALB), temperature, and number was 3 : 3, 37°C, and 1.0 × 108 CFU/g, respectively. After 48 h mixed fermentation, the number of probiotics increased to 2.2 × 109 CFU/g, pH decreased to 3.2, and high molecular weight proteins disintegrated into small molecular weight or soluble proteins. In addition, several holes appeared on the Astragalus surface. Compared with unfermented Astragalus, the content of Astragalus polysaccharide and calycosin increased by 3.82- and 1.31-fold, respectively, on fermentation and that of total Astragalus saponins decreased by 0.77-fold. Furthermore, on Cyprinid herpesvirus 2 (CyHV-2) and Aeromonas veronii (A. veronii) challenges, the cumulative survival rates of crucian carp fed common feed and ALB were 80.00% and 65.00%, respectively. Overall, feeding mixed fermentation products to crucian carp positively impacted their health and disease resistance. We believe that our results provide theoretical guidance for developing effective plant-based agents to prevent diseases in crucian carp.

show abstract

“…The extraction protocol P3 is that of Maamria et al [ 54 ]. One hundred grams of the Zaghouan population was macerated twice for 48 h in 1 L of EtOH/H 2 O (70:30).…”

Section: Methodsmentioning

confidence: 99%

Screening for Astragalus hamosus Triterpenoid Saponins Using HPTLC Methods: Prior Identification of Azukisaponin Isomers

et al. 2022

View full text Add to dashboard Cite

Due to their particular structural characteristics, the extraction and isolation of saponins from plants present a serious challenge. In this study, specific extraction protocols were first implemented to extract the secondary metabolites from Astragalus hamosus and, more precisely, the saponins. Subsequent purification of the extracts was based on a single chromatographic technique, high-performance thin-layer chromatography, applying two development systems: a one-step system that separated molecules according to their polarity and a multiple development system that made it possible to detect the triterpenoid saponins, azukisaponin or soyasapogenol at a retarded Rf of 0.2. The difficulties of detecting the Astragalus hamosus saponins encountered during the extraction and purification of the extracts have been highlighted and the strategy carried out to isolate the saponins has been discussed.

show abstract

Cycloartane glycosides from Astragalus gombo

Cited by 10 publications

References 24 publications

Chemical composition and antioxidant activity of Astragalus monspessulanus L. growing in semiarid areas of Algeria

Chemical composition and antioxidant activity of Astragalus monspessulanus L. growing in semiarid areas of Algeria

Synergistic Impact of Lactobacillus plantarum and Bacillus coagulans on Solid-State Fermentation of Astragalus and Effects of Fermentation Products on Disease Resistance of Crucian Carp (Carassius auratus)

Screening for Astragalus hamosus Triterpenoid Saponins Using HPTLC Methods: Prior Identification of Azukisaponin Isomers

Contact Info

Product

Resources

About