Cyclodextrin as a magic switch in covalent and non-covalent anticancer drug release systems

Tian, Bingren; Liu, Yumei; Liu, Jiayue

doi:10.1016/j.carbpol.2020.116401

Cited by 46 publications

(23 citation statements)

References 171 publications

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“…14 The native CDs typically contains six (a-CD), seven (b-CD) eight (g-CD) D-glucopyranose units linked by 1,4-glucoside bonds. [15][16][17] In terms of structure, CDs possess a hydrophilic outer surface and hydrophobic central cavity. 18 Because of the distinctive molecular structure of CDs, they are used as hosts to form inclusion complexes with various inorganic, organic and biological molecules.…”

Section: Introductionmentioning

confidence: 99%

Solubility and biological activity enhancement of docetaxel via formation of inclusion complexes with three alkylenediamine-modified β-cyclodextrins

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Solubility and biological activity enhancement of docetaxel via formation of inclusion complexes with three alkylenediamine-modified β-cyclodextrins

et al. 2021

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“…Similarly, b-cyclodextrin (b-CD) has been widely used in pharmaceutical field due to their excellent performance characteristics such as low toxicity, biodegradability, stability, biocompatibility, and ease of chemical modification (Zhang et al, 2020). A variety of cyclodextrinbased biological materials such as cyclodextrin polymers, cyclodextrin polyrotaxanes, and cyclodextrin dendrimers are widely used to construct drug carriers (Alvarez-Lorenzo et al, 2017;Tian et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin pendant polymer as an efficient drug carrier for scutellarin

Liao

Liu

et al. 2020

Drug Delivery

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A novel β-cyclodextrin pendant polymer (ε-PL-CD), composed of poly(ε-lysine) (ε-PL) main chain and glycine-β-cyclodextrin (Gly-CD) side chains, was prepared by a simple two-step procedure. The ε-PL-CD was investigated as a drug carrier of hydrophobic drug scutellarin (SCU). The characterization and complexation mode of the SCU:ε-PL-CD were researched in both solution and solid state by means of photoluminescence spectroscopy, 1 H and 2D NMR, X-Ray powder diffraction (XRPD), thermal gravimetric analysis, Particle size and Zeta potential. The solubility test indicated that the solubilizing ability of SCU:ε-PL-CD was significantly improved compared with SCU:β-CD and free SCU. Besides, in vitro cell experiment, it was found that SCU:ε-PL-CD has a strong inhibitory effect on the growth and invasion of tumor cells. The present study provides useful information for ε-PL-CD as a drug carrier material.

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“…The stability and water solubility of the guest can be improved in this manner, or the target guest can be captured, removed or masked, broadening application scopes. Indeed, the academic and (bio)technological interest for cyclodextrins has been historically dominated by their inclusion complex-formation ability, which has translated into numerous applications in fields like food [1,2], cosmetics [3], environment [4,5], and medicine [3,[6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin-Based Functional Glyconanomaterials

2020

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Cyclodextrins (CDs) have long occupied a prominent position in most pharmaceutical laboratories as “off-the-shelve” tools to manipulate the pharmacokinetics of a broad range of active principles, due to their unique combination of biocompatibility and inclusion abilities. The development of precision chemical methods for their selective functionalization, in combination with “click” multiconjugation procedures, have further leveraged the nanoscaffold nature of these oligosaccharides, creating a direct link between the glyco and the nano worlds. CDs have greatly contributed to understand and exploit the interactions between multivalent glycodisplays and carbohydrate-binding proteins (lectins) and to improve the drug-loading and functional properties of nanomaterials through host–guest strategies. The whole range of capabilities can be enabled through self-assembly, template-assisted assembly or covalent connection of CD/glycan building blocks. This review discusses the advancements made in this field during the last decade and the amazing variety of functional glyconanomaterials empowered by the versatility of the CD component.

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Cyclodextrin as a magic switch in covalent and non-covalent anticancer drug release systems

Cited by 46 publications

References 171 publications

Solubility and biological activity enhancement of docetaxel via formation of inclusion complexes with three alkylenediamine-modified β-cyclodextrins

Solubility and biological activity enhancement of docetaxel via formation of inclusion complexes with three alkylenediamine-modified β-cyclodextrins

Cyclodextrin pendant polymer as an efficient drug carrier for scutellarin

Cyclodextrin-Based Functional Glyconanomaterials

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