Cyclodextrin-based host–guest supramolecular hydrogels for local drug delivery

Fang, Guihua; Yang, Xuewen; Chen, Sumeng; Wang, Qiuxiang; Zhang, Aiwen; Tang, Bo

doi:10.1016/j.ccr.2021.214352

Cited by 89 publications

(53 citation statements)

References 161 publications

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“…The inner cavity is typically used to encapsulate size-matched guest molecules to form complexes through host-guest interactions. [55][56][57][58][59] Because of the differences in the number of D-glucose units in a-, b-, and g-CDs, the minimum internal diameter on the primary side, the maximum internal diameter on the secondary side, and the cavity volume are also different (Fig. 1b), meaning that guest molecules of different sizes can be encapsulated into the three hosts.…”

Section: Zhixue Liumentioning

confidence: 99%

Multicharged cyclodextrin supramolecular assemblies

Liu

2022

Chem. Soc. Rev.

143

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Section: Zhixue Liumentioning

confidence: 99%

Multicharged cyclodextrin supramolecular assemblies

Liu

2022

Chem. Soc. Rev.

143

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“…For these considerations, NPHbased hydrogels constructed with supramolecular combinations, such as hydrogen bonding, metal chelation, π−π interactions, hydrophobic interactions, and/or van de Waals forces, might be regarded as ideal hydrogels for bone regeneration, as NPH-based supramolecular hydrogels usually possess superior attributes in biocompatibility, biodegradability, injectability, and drug load and release profiles. 31,32 In contrast, covalently cross-linked hydrogels, such as polyacrylamide (PAM) and poly(acrylic acid) (PAA), containing these nondegradable components are usually elastic, robust, and stable in physiological environments, which usually inhibit tissue ingrowth and/or cause foreign body reactions and fibrotic capsules around implants. 31 Magnesium (Mg) is an essential element for humans and participates in various physiological and metabolic reactions.…”

mentioning

confidence: 99%

Magnesium Oxide Nanoparticle Coordinated Phosphate-Functionalized Chitosan Injectable Hydrogel for Osteogenesis and Angiogenesis in Bone Regeneration

Chen

Sheng

Lin

et al. 2022

ACS Appl. Mater. Interfaces

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Natural polysaccharide (NPH)-based injectable hydrogels have shown great potential for critical-sized bone defect repair. However, their osteogenic, angiogenic, and mechanical properties are insufficient. Here, MgO nanoparticles (NPs) were incorporated into a newly synthesized water-soluble phosphocreatine-functionalized chitosan (CSMP) water solution to form an injectable hydrogel (CSMP-MgO) via supramolecular combination between phosphate groups in CSMP and magnesium in MgO NPs to circumvent these drawbacks of chitosan-based injectable hydrogels. Water-soluble chitosan deviate CSMP was first synthesized by grafting methacrylic anhydride and phosphocreatine into a chitosan chain in a one-step lyophilization process. The phosphocreatine in this hydrogel not only provides sites to combine with MgO NPs to form supramolecular binding but also serves as the reservoir to control Mg 2+ release. As a result, the lyophilized CSMP-MgO hydrogels presented a porous structure with some small holes in the pore wall, and the pore diameters ranged from 50 to 100 μm. The CSMP-MgO injectable hydrogels were restricted from swelling in DI water (lowest swelling ratio was 16.0 ± 1.1 g/g) and presented no brittle failure during compression even at a strain above 85% (maximum compressive strength was 195.0 kPa) versus the control groups (28.0 and 41.3 kPa for CSMP and CSMP-MgO (0.5) hydrogels), with regulated Mg 2+ release in a stable and sustained manner. The CSMP-MgO injectable hydrogels promoted in vitro calcium phosphate (hydroxyapatite (HA) and tetracalcium phosphate (TTCP)) deposition in supersaturated calcium phosphate solution and presented no cytotoxicity to MC3T3-E1 cells; the CSMP-MgO hydrogel promoted MC3T3-E1 cell osteogenic differentiation with upregulation of BSP, OPN, and Osterix osteogenic gene expression and mineralization and HUVEC tube formation. Among them, CSMP-MgO (5) presented most of these properties. Moreover, this hydrogel (CSMP-MgO ( 5)) showed an excellent ability to promote new bone formation in critical-sized calvarial defects in rats. Thus, the CSMP-MgO injectable hydrogel shows great promise for bone regeneration.

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“…This occurs as the α-CD threads into the PEG chains as shown in Figure 9 (section 2e), and further interact between them through hydrogen bonds, creating junctions between the threaded polymer chains, and thus either increasing the viscoelasticity of the system or leading to gel formation. [180][181][182] Poudel and his group utilised this principle to form a supramolecular hydrogel comprising α-CD and PEG-b-PLA (Figure 11). [183] The structural integrity of this gel relied on both weak associative (hydrophobic) interactions between the PEG-PLA chains of neighbouring micelles and host-guest interactions between PEG chains and α-CD.…”

Section: Drug Deliverymentioning

confidence: 99%

“…The unique crosslinking interaction between α‐CD and polyethylene glycol (PEG) chains (host‐guest interactions) has been investigated as a means to alter the viscoelastic behaviour of a hydrogel by forming a so‐called ‘polyrotaxane’. This occurs as the α‐CD threads into the PEG chains as shown in Figure 9 (section 2e), and further interact between them through hydrogen bonds, creating junctions between the threaded polymer chains, and thus either increasing the viscoelasticity of the system or leading to gel formation [180–182] . Poudel and his group utilised this principle to form a supramolecular hydrogel comprising α‐CD and PEG‐b‐PLA (Figure 11).…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Supramolecular Hydrogels: Design Strategies and Contemporary Biomedical Applications

Omar

Ponsford

Dreiss

et al. 2022

Chemistry An Asian Journal

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Self‐assembly of supramolecular hydrogels is driven by dynamic, non‐covalent interactions between molecules. Considerable research effort has been exerted to fabricate and optimise supramolecular hydrogels that display shear‐thinning, self‐healing, and reversibility, in order to develop materials for biomedical applications. This review provides a detailed overview of the chemistry behind the dynamic physicochemical interactions that sustain hydrogel formation (hydrogen bonding, hydrophobic interactions, ionic interactions, metal‐ligand coordination, and host‐guest interactions). Novel design strategies and methodologies to create supramolecular hydrogels are highlighted, which offer promise for a wide range of applications, specifically drug delivery, wound healing, tissue engineering and 3D bioprinting. To conclude, future prospects are briefly discussed, and consideration given to the steps required to ultimately bring these biomaterials into clinical settings.

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Cyclodextrin-based host–guest supramolecular hydrogels for local drug delivery

Cited by 89 publications

References 161 publications

Multicharged cyclodextrin supramolecular assemblies

Multicharged cyclodextrin supramolecular assemblies

Magnesium Oxide Nanoparticle Coordinated Phosphate-Functionalized Chitosan Injectable Hydrogel for Osteogenesis and Angiogenesis in Bone Regeneration

Supramolecular Hydrogels: Design Strategies and Contemporary Biomedical Applications

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