Cyclodextrin-based metal-organic framework materials: Classifications, synthesis strategies and applications in variegated delivery systems

Zhao, Runan; Zhu, Beiwei; Xu, Yu; Yu, Songfeng; Wang, Wenjun; Liu, Donghong; Hu, Jiang‐Ning

doi:10.1016/j.carbpol.2023.121198

Cited by 21 publications

(6 citation statements)

References 125 publications

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“…Notably, drugs like ibuprofen, folic acid, sodium diclofenac, valsartan, and other drugs have been successfully encapsulated in CD-based MOFs using various crystallization protocols, including cocrystallization, vapor diffusion, hydrothermal, and others. These approaches have significantly improved the solubility and bioavailability of the drugs. , …”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin Metal–Organic Frameworks as a Drug Delivery System for Selected Active Pharmaceutical Ingredients

Kru̅kle-Be̅rziṇa,

Lends,

Boguszewska-Czubara

2024

ACS Omega

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The cyclodextrin-based metal−organic frameworks (CD MOFs) are a suitable molecular platform for drug delivery systems of various active pharmaceutical ingredients (APIs). The low toxicity and cost-efficient synthesis make CD MOFs an attractive host for the encapsulation of APIs. In this study, we created a model system based on γCD-K MOFs with widely used drugs carmofur (HCFU), 5fluorouracil (5-FU), and salicylic acid (HBA) to study host−guest encapsulation methods using different crystallization protocols. The host−guest complexes of API:CD MOF in an in-depth study were investigated by liquid chromatography−mass spectrometry (LC-MS), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and 19 F-and 13 C-detected solid-state NMR spectroscopy (ssNMR). These techniques confirmed the structure and interaction sites within the encapsulation product in the host−guest complex. We also evaluated the toxicity and biocompatibility of the API:CD MOF complex using in vitro and in vivo methods. The cytotoxicity, hepatotoxicity, and neurotoxicity were established with cell lines of fibroblasts (BJ), human liver cell line (HepG2), and human oligodendrocytic cells (MO3.13). Then, Danio rerio was used as an in vivo experimental model of ecotoxicity. The results showed the choice of γCD-K-5 as the most protective and safe option for drug encapsulation to decrease its toxicity level against normal cells.

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Section: Introductionmentioning

confidence: 99%

Cyclodextrin Metal–Organic Frameworks as a Drug Delivery System for Selected Active Pharmaceutical Ingredients

Kru̅kle-Be̅rziṇa,

Lends,

Boguszewska-Czubara

2024

ACS Omega

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“…Moreover, CDs are among the products yielded through the enzymatic degradation of naturally occurring starch. , The U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have approved natural CDs and some derivatives as safe additives . Owing to its advantages of being edible, strong inclusion ability, high loading capacity, and multifunctional role, CDs seem to be promising applications in the food and medicine fields. , Therefore, CD-MOFs exhibit high safety, biocompatibility, and biodegradability . Additionally, they demonstrate significant advantages in loading volatile components, solidifying volatile substances, enhancing solubility, and improving stability. − …”

Section: Introductionmentioning

confidence: 99%

“…23 Moreover, CDs are among the products yielded through the enzymatic degradation of naturally occurring starch. 24,25 The U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have approved natural CDs and some derivatives as safe additives. 24 Owing to its advantages of being edible, strong inclusion ability, high loading capacity, and multifunctional role, CDs seem to be promising applications in the food and medicine fields.…”

Section: Introductionmentioning

confidence: 99%

“…26,27 Therefore, CD-MOFs exhibit high safety, biocompatibility, and biodegradability. 28 Additionally, they demonstrate significant advantages in loading volatile components, solidifying volatile substances, enhancing solubility, and improving stability. 29−31 Based on the volatile characteristics of I 2 , our research group have already loaded I 2 into KI-γ-CD-MOF as iodine vapors without introducing any solvent.…”

Section: Introductionmentioning

confidence: 99%

“…Cyclodextrin metal–organic frameworks (CD-MOFs) are porous framework materials formed by the coordination of cyclodextrin (CD) with alkali metal ions. , In terms of its components, metal ions, such as K + , Ca 2+ , and Na + , are mostly safe and nontoxic . Moreover, CDs are among the products yielded through the enzymatic degradation of naturally occurring starch. , The U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have approved natural CDs and some derivatives as safe additives . Owing to its advantages of being edible, strong inclusion ability, high loading capacity, and multifunctional role, CDs seem to be promising applications in the food and medicine fields. , Therefore, CD-MOFs exhibit high safety, biocompatibility, and biodegradability .…”

Section: Introductionmentioning

confidence: 99%

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Supramolecular Structure of the β-Cyclodextrin Metal–Organic Framework Optimizes Iodine Stability and Its Co-delivery with l-Menthol for Antibacterial Applications

Zhao,

Li,

Guo

et al. 2024

ACS Appl. Mater. Interfaces

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The spread of upper respiratory tract (URT) infections harms people's health and causes social burdens. Developing targeted treatment strategies for URT infections that exhibit good biocompatibility, stability, and strong antimicrobial effects remains challenging. The dual antimicrobial and antiviral effects of iodine (I 2 ) in combination with the cooling sensation of L-menthol in the respiratory tract can simultaneously alleviate URT inflammation symptoms. However, as both I 2 and L-menthol are volatile, addressing stability issues is crucial. In this study, a potassium iodide β-cyclodextrin metal−organic framework [β-CD-POF(I)] with appropriate particle size was used to coload and deliver I 2 and L-menthol. Primarily, β-CD-POF(I) was employed as the most efficient carrier to significantly enhance the stability of I 2 , surpassing any other known protection strategies in the pharmaceutical field (CD complexations, PVP conjugations, and cadexomer iodine). The mechanism underlying the improvement in stability of I 2 by β-CD-POF(I) was investigated through scanning electron microscopy with energy-dispersive X-ray spectroscopy, Xray photoelectron spectroscopy, Raman spectroscopy, and molecular docking. The results revealed that the key processes involved in improving stability were the inclusion of I 2 by β-CD cavities in β-CD-POF(I) and the formation of polyiodide anion between iodine ions and I 2 . Furthermore, the potential of β-CD-POF(I) to load and deliver drugs was validated, and coloading of L-menthol and I 2 demonstrated reliable stability. β-CD-POF(I) achieved a rate of URT deposition ≥95% in vitro, and the combined antibacterial effects of coloaded I 2 and L-menthol was better than I 2 or PVP-I alone, with no irritation noted following URT administration in rabbits. Therefore, the stable coloading of drugs by β-CD-POF(I), leading to enhanced antimicrobial effects, provides a new strategy for treating URT infections.

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CD-MOFs: From preparation to drug delivery and therapeutic application

Si,

Luo,

Zhang

et al. 2024

Carbohydrate Polymers

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Cyclodextrin-based metal-organic framework materials: Classifications, synthesis strategies and applications in variegated delivery systems

Cited by 21 publications

References 125 publications

Cyclodextrin Metal–Organic Frameworks as a Drug Delivery System for Selected Active Pharmaceutical Ingredients

Cyclodextrin Metal–Organic Frameworks as a Drug Delivery System for Selected Active Pharmaceutical Ingredients

Supramolecular Structure of the β-Cyclodextrin Metal–Organic Framework Optimizes Iodine Stability and Its Co-delivery with l-Menthol for Antibacterial Applications

CD-MOFs: From preparation to drug delivery and therapeutic application

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