Cyclodextrin-based nanosponges: A critical review

Sherje, Atul P.; Dravyakar, Bhushan R.; Kadam, Darshana; Jadhav, Mrunal

doi:10.1016/j.carbpol.2017.05.086

Cited by 277 publications

(168 citation statements)

References 115 publications

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“…According to the literature, CDNS has small total pore volume, which is much lower than that of SBA‐15. From a comparison of the total pore volume of CDNS–SBA‐15 and Ag@CDNS–SBA‐15, it can be concluded that, upon incorporation of silver nanoparticles in CDNS–SBA‐15, a slight decrease in total pore volume is observed.…”

Section: Resultsmentioning

confidence: 98%

“…Reaction of cyclodextrin with an appropriate cross‐linking agent such as diphenyl carbonate, carbonyl diimidazole or dimethyl carbonate results in the formation of a non‐toxic, insoluble cyclodextrin‐based hyper‐cross‐linked polymer, known as a cyclodextrin nanosponge (CDNS) . CDNS are stable over a wide range of temperature and pH and benefit from both the cavities of the cyclodextrin monomer and the cavities arising from the polymeric network.…”

Section: Introductionmentioning

confidence: 99%

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Bio‐assisted synthesized Ag(0) nanoparticles immobilized on SBA‐15/cyclodextrin nanosponge adduct: Efficient heterogeneous catalyst for the ultrasonic‐assisted synthesis of benzopyranopyrimidines

Sadjadi

Heravi

Malmir

2018

Applied Organom Chemis

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For the first time, SBA-15/cyclodextrin nanosponge adduct was synthesized through reaction of Cl-functionalized SBA-15 and amine-functionalized cyclodextrin nanosponge (CDNS). This adduct, which benefits from features of both SBA-15 and CDNS, was then used for immobilization of Ag (0) nanoparticles which were prepared and capped using a bio-based approach.Ag@CDNS-SBA-15 was applied as a heterogeneous catalyst for promoting the three-component reaction of benzaldehydes, 4-hydroxycoumarin and urea or thiourea under ultrasonic irradiation to furnish benzopyranopyrimidines. The reaction variables were optimized using response surface methodology.The catalytic activity of Ag@CDNS-SBA-15 was higher than those of Ag@CDNS, Ag@SBA-15 and Ag@SBA-15 + CDNS, confirming the contribution of both components to catalysis as well as a synergistic effect between CDNS and SBA-15. The role of CDNS was to accommodate the substrates and bring them to the vicinity of the Ag(0) nanoparticles. Notably the catalyst was reusable and could be recovered and reused for up to four reaction runs with slight Ag(0) leaching and loss of catalytic activity.

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Section: Resultsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Bio‐assisted synthesized Ag(0) nanoparticles immobilized on SBA‐15/cyclodextrin nanosponge adduct: Efficient heterogeneous catalyst for the ultrasonic‐assisted synthesis of benzopyranopyrimidines

Sadjadi

Heravi

Malmir

2018

Applied Organom Chemis

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“…Among these, they have been predominantly studied for drug delivery. Numerous active molecules including lipophilic and hydrophilic actives and volatile oils can be conventionally entrapped in these multifaceted nanostructures for solubility and stability enhancement and for controlled delivery [7]. Hence, these novel carriers have attracted much interest of formulation scientists as they hold promise in addressing other challenges like poor bioavailability, permeation and therapeutic activity [69].…”

Section: Nanosponges In Drug Deliverymentioning

confidence: 99%

“…Nanosponges are a new class of structures based on hyper reticulated polymers that have cavities in the nanorange [7,8]. Nanosponge technology offers pay load of active moieties and thought to help in reducing side effects, increase elegance, improve formulation flexibility and stability.…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin Nanosponges: A Promising Approach for Modulating Drug Delivery

Kumar¹,

Dalal²,

Rao³

2020

Colloid Science in Pharmaceutical Nanotechnology

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Nanotechnology showed great promise and impact on administration of therapeutic agents owing to its advantages over contemporary delivery systems. Nanoscale carriers like nanosponges represent a novel category of hyper crosslinked polymer structures with nanosized cavities which can be filled with variety of active moieties (hydrophilic as well as hydrophobic). These nanocarriers can circulate around the body until they found the specific target site and adhere on the surface and release the active moiety in a predictable and controlled manner, resulting in more effective delivery of a given dosage. Nanosponge technology helps to reduce drug associated side effects, improve stability, increase elegance and improve the flexibility of formulations, administered orally, parenterally and topically. Among nanosponges, cyclodextrin-based nanosponges (CDNS) are smart versatile carriers studied widely for drug delivery applications. Statistically, it have presented that approximately 40% of active moieties marketed currently and about 90% of active moieties in their preliminary phase confront problems regarding to solubility. In the past decade, the number of studies describing CDNS has dramatically increased. In the present chapter, scientists working in arena of nanotechnology can get an idea of fabrication, characterization and therapeutic utilities of nanosponges.

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“…CCPs have been employed in designing assemblies (hydrogels, micelles, and nanoparticles) with a range of bio‐applications, from complexing disinfecting drugs for control release in wound and burn treatments to delivery vehicles for nucleic acids, from the construction of biosensors for cocaine to sophisticated host–guest assemblies for regenerative medicine . In general, CCPs offer several advantages over the simple monomeric CDs, such as: i) improved water solubility for the presence of several CD units, ii) higher catalytic effect and iii) greater drug‐loading capacity . The improved binding abilities are essentially due to the cooperation of several adjacent CD moieties to bind guest molecules that are too large to be accommodated in a single CD cavity .…”

Section: Cds Embedded Into Polymeric Structurementioning

confidence: 99%

Cyclodextrin‐Based Macromolecular Systems as Cholesterol‐Mopping Therapeutic Agents in Niemann–Pick Disease Type C

Puglisi

Yaǧcı

2018

Macromol. Rapid Commun.

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Over the last decade, cyclodextrins (CDs) have gained considerable attention as a potential therapeutic intervention in the treatment of the rare genetic condition Niemann-Pick type C disease (NPC). However, the oligosaccharide in its monomeric form suffers from serious side effects, especially from a pharmacokinetic and biodistribution standpoint. CD-based macromolecular systems hold great promise to overcome such limitations and might provide an improved therapeutic approach in reducing cholesterol accumulation in NPC. In the present article, the latest developments and synthetic strategies in the preparation of CD-containing polymers as cholesterol-mopping therapeutic agents in NPC are summarized.

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Cyclodextrin-based nanosponges: A critical review

Cited by 277 publications

References 115 publications

Bio‐assisted synthesized Ag(0) nanoparticles immobilized on SBA‐15/cyclodextrin nanosponge adduct: Efficient heterogeneous catalyst for the ultrasonic‐assisted synthesis of benzopyranopyrimidines

Bio‐assisted synthesized Ag(0) nanoparticles immobilized on SBA‐15/cyclodextrin nanosponge adduct: Efficient heterogeneous catalyst for the ultrasonic‐assisted synthesis of benzopyranopyrimidines

Cyclodextrin Nanosponges: A Promising Approach for Modulating Drug Delivery

Cyclodextrin‐Based Macromolecular Systems as Cholesterol‐Mopping Therapeutic Agents in Niemann–Pick Disease Type C

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