Cyclodextrin-based nanosponges of curcumin: formulation and physicochemical characterization

Molecular Inclusion Complex of Curcumin–β-Cyclodextrin Nanoparticle to Enhance Curcumin Skin Permeability from Hydrophilic Matrix Gel

“…Therefore, this polydispersity index is considered a homogenous formulation or uniform particle size distribution. These BCD-CUR-Ns have a negative surface charge (Table III) reflecting by the zeta potential value, as also reported by other group [16]. Negative charge at the surface indicates that the molecular aligning of the amphiphilic BCDs are such that the unsubstituted -OH groups are pointing towards the aqueous surrounding rendering a potential surface hydrophilicity.…”

Cyclodextrin‐Based Nanosponges for Improving Solubility and Sustainable Release of Curcumin

“…On the contrary, curcumin exhibited several characteristic peaks at 2θ=8.870, 12.410, 17.480, 18.350, 25.440, 26.500, confirming the crystalline nature of pristine curcumin . In XRD patterns of all three C–CDNS samples, the characteristic peaks of curcumin are absent, broad and weak, implying the molecularly loading of C on CDNS …”

“…Furthermore, the P−C‐CDNS, F−C‐CDNS, and I−C‐CDNS curves illustrated no phase transition, demonstrating that the encapsulation of the curcumin molecules into the nanosponges, possibly attributed to the molecularly dispersion of curcumin in polymeric matrix and cavities (Figure c, 4d, and 4e). Thus, this finding revealed that curcumin lost its crystallinity and confirmed its molecule entrapment into the nanosponges structure …”

“…Lately, nanotechnology has been applied for circumventing the drawbacks of curcumin. In this line, encapsulation of drugs in carries such as CDNS, proteins and liposomes via hydrophobic interactions, have been used to enhance the solubility and bioavailability of curcumin drug . Among all, CDNSs provide great advantages over the other methods due to the high capacity for drug loading, prolong release and cost effectiveness.…”

Glucosamine anchored cancer targeted nano-vesicular drug delivery system of doxorubicin

“…Furthermore, nanocarriers functionalized with targeting ligand can lead to preferential localization of anticancer agent into cancerous cells which ultimately improve the specificity, therapeutic index and reduce systemic toxicity [9,10]. There are various nanocarrier drug delivery systems studied to deliver anticancer agents, such as polymer conjugate [11], polymeric micelles [12], polymeric nanoparticles [13], nanosponges [14], niosomes [15] and liposomes [16]. Liposomes are most widely explored for anticancer formulation and are very well accepted approach; however, liposomes have some reservations, viz storage stability (mainly oxidation of phospholipid) and leakage of entrapped drugs.…”