Cyclodextrin-enabled nepafenac eye drops with improved absorption open a new therapeutic window

Vincze, Anna; Facskó, Réka; Budai-Szűcs, Mária; Katona, Gábor; Csorba, Anita; Zelkó, Romána; Nagy, Zoltán Zsolt; Szente, Lajos; Balogh, György Tibor

doi:10.1016/j.carbpol.2023.120717

Cited by 2 publications

(1 citation statement)

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“…The host-guest interaction is a stable intermolecular interaction formed by the synergy of multiple noncovalent bonding interaction forces (e.g., hydrogen bonding, hydrophobic interactions, and van der Waals forces), which is highly useful for drug release and pH response. [35,36] However, little attention has been paid to rationalizing the use of host-guest interactions to manipulate 2D nanosheets for ordered assembly and to modulate the chemistry of interlayer channels in 2D membranes, which may obscure the great potential of such interactions in the preparation of high-performance 2D lamellar membranes.…”

Section: Introductionmentioning

confidence: 99%

From Sheep Track to Motorway: Supramolecular‐Mediated 2D Nanofluidic Channels for Ultrafast Water Transport

Zhu,

Guo,

et al. 2023

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Atomic thick 2D materials hold great potential as building blocks to construct highly permeable membranes, yet the permeability of laminar 2D material membranes is still limited by their irregularity sheep track‐like interlayer channels. Herein, a supramolecular‐mediated strategy to induce the regular assembly of high‐throughput 2D nanofluidic channels based on host–guest interactions is proposed. Inspired by the characteristics of motorways, supramolecular‐mediated ultrathin 2D membranes with broad and continuous regular water transport channels are successfully constructed using graphene oxide (GO) as an example. The prepared membrane achieves an ultrahigh water permeability (369.94 LMH bar−1) more than six times higher than that of the original membranes while maintaining dye rejection above 98.5%, which outperforms the reported 2D membranes. Characterization and simulation results show that the introduction of hyaluronate‐grafted β‐cyclodextrin not only expands the interlayer channels of GO membranes but also enables the membranes to operate stably under harsh conditions with the help of host–guest interactions. This universal supramolecular assembly strategy provides new opportunities for the preparation of 2D membranes with high separation performance and reliable and stable nanofluidic channels.

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Section: Introductionmentioning

confidence: 99%