Cyclodextrin-MEEKC for the analysis of oxybutynin and its impurities

Giannini, Iacopo; Orlandini, Serena; Gotti, Roberto; Pinzauti, S.; Furlanetto, Sandra

doi:10.1016/j.talanta.2009.07.071

Cited by 32 publications

(18 citation statements)

References 27 publications

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“…Furthermore, it could be realized by varying of the type and concentration of the surfactant, oil, and cosolvent so as to adjust the microemulsion composition for promoting of the separation selectivity of some nonpolar solutes. 30 Based on these experiences about the MEEKC, it could be expected that more efficient separation is possible upon optimization of the microemulsion composition.…”

Section: Microemulsion Composition Optimizationmentioning

confidence: 99%

Chiral Separation of Sertraline with Microemulsion Electrokinetic Chromatography on a Polymer/β-cyclodextrin Assembling Molecular Film Modified Capillary

Zhang

Tu³

2010

ANAL. SCI.

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A capillary modified by assembling a molecular film was presented for the chiral separation of sertraline by microemulsion electrokinetic chromatography. The assembling molecular film was constructed with poly(diallyldimethylammoniumchloride) and β-cyclodextrin via inclusion complexation. The separation efficiency of cis-trans isomers and enantiomers of sertraline was improved with a running microemulsion that contained the acetonitrile, sodium dodecyl sulfate, n-butanol and n-hexane buffered with sodium tetraborate. The baseline separation of four sertraline cis-trans isomers and enantiomers was achieved under the optimum conditions. The detection limit for isomers and enantiomers of sertraline (1S,4S, 1R,4R, 1S,4R, 1R,4S) was 0.15, 0.15, 0.30, 0.30 mg/L, respectively. The mechanism of chiral separation was studied and it could be applied for the determination of commercial Zoloft tablet samples satisfactorily.

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Section: Microemulsion Composition Optimizationmentioning

confidence: 99%

Chiral Separation of Sertraline with Microemulsion Electrokinetic Chromatography on a Polymer/β-cyclodextrin Assembling Molecular Film Modified Capillary

Zhang

Tu³

2010

ANAL. SCI.

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“…DD needs fewer experiments, which makes it more efficient and can easily move through the experimental domain if the optimum is not in the initially studied domain. For these reasons, DD is a widespread chemometric tool used for parameter optimization in many fields, such as analytical chemistry [23][24][25][26][27], chemical engineering [28,29], and pharmacy [30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Rational design of core–shell molecularly imprinted polymer based on computational simulation and Doehlert experimental optimization: application to the separation of tanshinone IIA from Salvia miltiorrhiza Bunge

Jia

Luo

et al. 2012

Anal Bioanal Chem

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Computational simulation and Doehlert experimental optimization were done for the rational design of a core-shell molecularly imprinted polymer (CS-MIP) for use in the highly selective separation of Tanshinone IIA (TSIIA) from the crude extracts of Salvia miltiorrhiza Bunge (SMB). The functional monomer layer of the polymer shells directed the selective occurrence of imprinting polymerization at the surface of silica through the copolymerization of vinyl end groups with functional monomers and also drove TSIIA templates into the formed polymer shells through the charge-transfer complex interactions between TSIIA and the functional monomer layer. As a result, the maximum rebinding capacity was achieved with the use of optimal grafting ratio by the Doehlert design. The CS-MIP exhibited high recognition selectivity and binding affinity to TSIIA. When the imprinted particles were used as dispersive solid phase extraction sorbents, the recovery yield of TSIIA reached 93% by a one-step extraction from the crude extracts of SMB, and the purity of TSIIA was larger than 98% by HPLC analysis. These results show the possibility of a highly selective separation and enrichment of TSIIA from the SMB using the TSIIA-imprinted core-shell molecularly imprinted polymers.

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“…This attribution is appealing for a laboratory routinely performing identity confirmation testing of a diverse range of product types. Recent applications of MEEKC include determination of insulin and related synthetic analogues [8], analysis of oxybutynin and its impurities [9] and the high-throughput determination of log P values by MEEKC [10].…”

Section: Introductionmentioning

confidence: 99%

Use of a Single Capillary Electrophoresis Method as a Routine Identity Test for Batch Release of a Range of Pharmaceutical Products

et al. 2011

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Two independent and orthogonal analytical methods are required when performing identity testing of pharmaceutical products during routine release testing. A microemulsion electrokinetic chromatography method has been developed and validated for routine use as an identity test to release various pharmaceutical products including tablets, capsules and creams. Implementation of the method involved optimisation of parameters to achieve reliable routine operation. Rinsing procedures, in particular, were found to be essential to obtain consistent profiles and migration times. The method has replaced, and offers the potential to replace, a number of methods including HPLC and IR due to the considerable cost and time savings obtained through its use. This method has been successfully approved by the US FDA as a part of 2 New Drug Applications, is registered in Japan, and is in routine QA use within a factory environment.

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Cyclodextrin-MEEKC for the analysis of oxybutynin and its impurities

Cited by 32 publications

References 27 publications

Chiral Separation of Sertraline with Microemulsion Electrokinetic Chromatography on a Polymer/β-cyclodextrin Assembling Molecular Film Modified Capillary

Chiral Separation of Sertraline with Microemulsion Electrokinetic Chromatography on a Polymer/β-cyclodextrin Assembling Molecular Film Modified Capillary

Rational design of core–shell molecularly imprinted polymer based on computational simulation and Doehlert experimental optimization: application to the separation of tanshinone IIA from Salvia miltiorrhiza Bunge

Use of a Single Capillary Electrophoresis Method as a Routine Identity Test for Batch Release of a Range of Pharmaceutical Products

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