Cyclodextrins as “smart” components of polymer nanoparticles

Gref, Ruxandra; Duchêne, Dominique

doi:10.1016/s1773-2247(12)50033-x

Cited by 27 publications

(10 citation statements)

References 99 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, CD encapsulation could reduce or prevent irritation and other side-effects of the drugs, enhance drug permeation across the biological membranes, prevent drug-to-drug and drug-to-excipient interactions, favorably modify organoleptic characteristics of included molecule and even convert liquid and volatile compounds in technologically more acceptable free-flowing powders [2,3,4,5,6,7]. Finally, CDs are often introduced into a wide range of advanced drug delivery formulations, ranging from monolithic to micro and nano-particulate ones, in order to target and control the drug release kinetic in accordance with the therapeutic needs [8,9,10,11]. In some cases, addition of a third component, such as polymers, organic acids, metal ions, or lipids could additionally enhance CD efficiency through a ternary complex formation [1].…”

Section: Introductionmentioning

confidence: 99%

Grinding as Solvent-Free Green Chemistry Approach for Cyclodextrin Inclusion Complex Preparation in the Solid State

Jug

Mura

2018

Pharmaceutics

View full text Add to dashboard Cite

Among the different techniques proposed for preparing cyclodextrin inclusion complex in the solid state, mechanochemical activation by grinding appears as a fast, highly efficient, convenient, versatile, sustainable, and eco-friendly solvent-free method. This review is intended to give a systematic overview of the currently available data in this field, highlighting both the advantages as well as the shortcomings of such an approach. The possible mechanisms involved in the inclusion complex formation in the solid state, by grinding, have been illustrated. For each type of applied milling device, the respective process variables have been examined and discussed, together with the characteristics of the obtained products, also in relation with the physicochemical characteristics of both the drug and cyclodextrin subjected to grinding. The critical process parameters were evidenced in order to provide a useful guide for a rational selection of the most suitable conditions for an efficient inclusion complex preparation by grinding, with the final purpose of promoting a wider use of this effective solvent-free cyclodextrin inclusion complex preparation method in the solid state.

show abstract

Section: Introductionmentioning

confidence: 99%

Grinding as Solvent-Free Green Chemistry Approach for Cyclodextrin Inclusion Complex Preparation in the Solid State

Jug

Mura

2018

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…By improving the physico-chemical properties of the drugs, such as stability, solubility and bioavailability, CDs clearly appear to be not just simple additives, but rather "smart" parts of the drug delivery devices. 1,2 Taking advantage of the peculiar structure of the CDs and their unique properties, particles made of crosslinked CDs became popular in recent years. 3 In particular, cyclodextrin cross-linked polymers or so called "nanosponges" (CD-sponges) have been proposed as a new nanosized drug delivery system but display inhomogeneous morphologies and size distributions in the micron range.…”

Section: Introductionmentioning

confidence: 99%

Template-directed synthesis of a cubic cyclodextrin polymer with aligned channels and enhanced drug payload

Singh

Guo

et al. 2017

RSC Adv.

View full text Add to dashboard Cite

Despite its 3D porous structure, the pharmaceutical applications of cyclodextrin based cross-linked polymers are limited due to their structural irregularities. To address this issue, a template-directed strategy is used to obtain cubic micro and nano cyclodextrin cross-linked polymer (CD-cubes) from cyclodextrin metal organic frameworks in this study. The well-organized g-CDs in MOFs were crosslinked by diphenyl carbonate by a facile single step chemical reaction. Scanning electron microscopy and X-ray diffraction analysis revealed the almost perfect cubic shapes of the particles with a disordered internal structure. Contrarily to the non-crosslinked materials which immediately dissolved in water, the CD-cubes were remarkably stable after extensive washing with water. The CD-cubes possessed a mesoporous structure with pore size in the range of 2-4 nm and showed much higher BET surface and 8 times higher adsorption capacity for doxorubicin as compared to conventional cyclodextrin-sponges. † Electronic supplementary information (ESI) available: Experimental details, SEM images of CD-MOFs and sponges, BET characterizations of CD-MOFs and sponges, FTIR spectra and doxorubicin adsorptions curves. See

show abstract

“…Biocompatible cyclodextrins (CDs) emerged as materials of choice for nanoMOF coating 38 . CDs, well known to improve the physicochemical properties of drugs (stability, solubility and bioavailability) 39 are considered as “smart” parts of the drug delivery devices 40 . Phosphated CDs (CD-P) were selected since: i) they are bulkier with regard to the nanoMOF windows (15.4 × 7.9 vs .…”

mentioning

confidence: 99%

A “green” strategy to construct non-covalent, stable and bioactive coatings on porous MOF nanoparticles

Agostoni

Horcajada

Noiray

et al. 2015

Sci Rep

Self Cite

158

164

View full text Add to dashboard Cite

Nanoparticles made of metal-organic frameworks (nanoMOFs) attract a growing interest in gas storage, separation, catalysis, sensing and more recently, biomedicine. Achieving stable, versatile coatings on highly porous nanoMOFs without altering their ability to adsorb molecules of interest represents today a major challenge. Here we bring the proof of concept that the outer surface of porous nanoMOFs can be specifically functionalized in a rapid, biofriendly and non-covalent manner, leading to stable and versatile coatings. Cyclodextrin molecules bearing strong iron complexing groups (phosphates) were firmly anchored to the nanoMOFs' surface, within only a few minutes, simply by incubation with aqueous nanoMOF suspensions. The coating procedure did not affect the nanoMOF porosity, crystallinity, adsorption and release abilities. The stable cyclodextrin-based coating was further functionalized with: i) targeting moieties to increase the nanoMOF interaction with specific receptors and ii) poly(ethylene glycol) chains to escape the immune system. These results pave the way towards the design of surface-engineered nanoMOFs of interest for applications in the field of targeted drug delivery, catalysis, separation and sensing.

show abstract

Cyclodextrins as “smart” components of polymer nanoparticles

Cited by 27 publications

References 99 publications

Grinding as Solvent-Free Green Chemistry Approach for Cyclodextrin Inclusion Complex Preparation in the Solid State

Grinding as Solvent-Free Green Chemistry Approach for Cyclodextrin Inclusion Complex Preparation in the Solid State

Template-directed synthesis of a cubic cyclodextrin polymer with aligned channels and enhanced drug payload

A “green” strategy to construct non-covalent, stable and bioactive coatings on porous MOF nanoparticles

Contact Info

Product

Resources

About