Cyclodextrins-Peptides/Proteins Conjugates: Synthesis, Properties and Applications

Łagiewka, Jakub; Girek, Tomasz; Ciesielski, Wojciech

doi:10.3390/polym13111759

Cited by 23 publications

(8 citation statements)

References 148 publications

(159 reference statements)

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“…Albumin accumulates in certain tumor cells via macropinocytosis, so albumin-coupled cytotoxic drugs can be designed to carry anticancer agents ( Lagiewka et al, 2021 ). Nab-paclitaxel, a widely applied clinical nanomedicine, is a nano-albumin-bound drug that leverages the therapeutic potential of macropinocytosis ( Adkins et al, 2021 ).…”

Section: Anticancer Therapies Targeting Macropinocytosismentioning

confidence: 99%

The Role and Therapeutic Potential of Macropinocytosis in Cancer

et al. 2022

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Macropinocytosis, a unique endocytosis pathway characterized by nonspecific internalization, has a vital role in the uptake of extracellular substances and antigen presentation. It is known to have dual effects on cancer cells, depending on cancer type and certain microenvironmental conditions. It helps cancer cells survive in nutrient-deficient environments, enhances resistance to anticancer drugs, and promotes invasion and metastasis. Conversely, overexpression of the RAS gene alongside drug treatment can lead to methuosis, a novel mode of cell death. The survival and proliferation of cancer cells is closely related to macropinocytosis in the tumor microenvironment (TME), but identifying how these cells interface with the TME is crucial for creating drugs that can limit cancer progression and metastasis. Substantial progress has been made in recent years on designing anticancer therapies that utilize the effects of macropinocytosis. Both the induction and inhibition of macropinocytosis are useful strategies for combating cancer cells. This article systematically reviews the general mechanisms of macropinocytosis, its specific functions in tumor cells, its occurrence in nontumor cells in the TME, and its application in tumor therapies. The aim is to elucidate the role and therapeutic potential of macropinocytosis in cancer treatment.

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Section: Anticancer Therapies Targeting Macropinocytosismentioning

confidence: 99%

The Role and Therapeutic Potential of Macropinocytosis in Cancer

et al. 2022

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“…Lagiewka et al [197] Cyclodextrin-Containing Hydrogels: A Review of Preparation Method, Drug Delivery, and Degradation Behavior…”

Section: Title Of Review Focus Of Review Referencementioning

confidence: 99%

Microbial Cyclodextrin Glycosyltransferases: Sources, Production, and Application in Cyclodextrin Synthesis

Gupta¹,

Tyagi²,

Pathak³

et al. 2022

Catal Res

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Cyclodextrin glycosyltransferase (CGTase) is a multifunctional enzyme that hydrolyzes the α-glycosidic bond between two sugar molecules and synthesizes cyclodextrins (CDs) and other transglycosylation products. It is a ubiquitously present extracellular enzyme that offers the CGTase-producing organism the sole right onto starch substrates over other microbes. The present review provides a brief account of diversity among CGTase-producing microbes, CGTase production in different heterologous hosts (wherein extracellular secretion is highly desired), and different physicochemical properties of CGTases. Overall, 52 crystal structures that highlight the five domain tertiary structure of CGTases have been discovered so far. On the basis of these structures, the catalytic mechanism of CGTase reactions has been discussed, and three catalytic residues, namely Glu257, Asp229, and Asp328, have been identified at the active site in all CGTases. Moreover, the active site is constituted by at least nine sugar-binding sites, denoted as -7 to +2. Furthermore, a sequence alignment of selected CGTases highlighted the conserved regions and the sequential differences among α-CGTases, β-CGTases, and γ-CGTases. Various biotechnological applications of CGTases and CGTase immobilization on a variety of support matrices are briefly discussed. This review also encompasses a detailed account of CDs, their enzymatic production, extraction, and applications in different industrial sectors.

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“…Cyclodextrin (CD), a cyclic oligosaccharide, is a known host molecule with a central cavity that allows the inclusion of a guest drug molecule [ 8 , 9 , 10 , 11 ]. Remarkably, chemically incorporating functional molecules into CDs is an interesting strategy that strengthens the site-specific bioreaction of CDs, which has often been used to improve drug therapeutic efficacy [ 10 , 11 , 12 , 13 ]. Recently, multifunctional CD-based nanoparticles (NPs) have been widely reported for the efficient transportation of antitumor drugs to tumors in response to specific stimuli such as temperature, light, redox, and pH [ 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Development of pH-Responsive Hyaluronic Acid-Conjugated Cyclodextrin Nanoparticles for Chemo-/CO-Gas Dual Therapy

Lee

2023

Pharmaceutics

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In this study, we fabricated γ-cyclodextrin (γCD)-based nanoparticles (NPs) for dual antitumor therapy. First, γCD (the backbone biopolymer) was chemically conjugated with low-molecular-weight hyaluronic acid (HA; a tumoral CD44 receptor-targeting molecule) and 3-(diethylamino)propylamine (DEAP; a pH-responsive molecule), termed as γCD-(DEAP/HA). The obtained γCD-(DEAP/HA) self-assembled in aqueous solution, producing the γCD-(DEAP/HA) NPs. These NPs efficiently entrapped paclitaxel (PTX; an antitumor drug) and triiron dodecacarbonyl (FeCO; an endogenous cytotoxic gas molecule) via hydrophobic interactions between PTX and FeCO with the unprotonated DEAP molecules in γCD-(DEAP/HA) and a possible host–guest interaction in the γCD rings. The release of PTX and FeCO from the NPs resulted from particle destabilization at endosomal pH, probably owing to the protonation of DEAP in the NPs. In vitro studies using MCF-7 tumor cells demonstrated that these NPs were efficiently internalized by the cells expressing CD44 receptors and enhanced PTX/FeCO-mediated tumor cell apoptosis. Importantly, local light irradiation of FeCO stimulated the generation of cytotoxic CO, resulting in highly improved tumor cell death. We expect that these NPs have potential as dual-modal therapeutic candidates with enhanced antitumor activity in response to acidic pH and local light irradiation.

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Cyclodextrins-Peptides/Proteins Conjugates: Synthesis, Properties and Applications

Cited by 23 publications

References 148 publications

The Role and Therapeutic Potential of Macropinocytosis in Cancer

The Role and Therapeutic Potential of Macropinocytosis in Cancer

Microbial Cyclodextrin Glycosyltransferases: Sources, Production, and Application in Cyclodextrin Synthesis

Development of pH-Responsive Hyaluronic Acid-Conjugated Cyclodextrin Nanoparticles for Chemo-/CO-Gas Dual Therapy

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