Cycloidal Computed Tomography

Hagen, Charlotte K.; Vittoria, Fabio A.; Morgó, Oriol Roche i; Endrizzi, Marco; Olivo, Alessandro

doi:10.1103/physrevapplied.14.014069

Cited by 23 publications

(31 citation statements)

References 24 publications

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“…The cycloidal CT images acquired with the step‐and‐shoot, continuous unidirectional, and continuous back‐and‐forth strategies have similar resolutions, between 20 and 40 µm, with step‐and‐shoot being slightly better than the other two. This agrees with previous results, where the in‐slice resolution of the step‐and‐shoot approach was found to be only slightly below that of the dithered image 7 . Among the cycloidal CT images, the continuous pixel‐wise approach yields the lowest resolution around 50 µm.…”

Section: Resultssupporting

confidence: 92%

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Technical Note: Practical implementation strategies of cycloidal computed tomography

et al. 2021

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Purpose: Cycloidal computed tomography is a novel imaging concept which combines a highly structured x-ray beam, offset lateral under-sampling, and mathematical data recovery to obtain highresolution images efficiently and flexibly, even with relatively large source focal spots and detector pixels. The method reduces scanning time and, potentially, delivered dose compared to other sampling schemes. This study aims to present and discuss several implementation strategies for cycloidal computed tomography (CT) in order to increase its ease of use and facilitate uptake within the imaging community. Methods: The different implementation strategies presented are step-and-shoot, continuous unidirectional, continuous back-and-forth, and continuous pixel-wise scanning. In step-and-shoot scans the sample remains stationary while frames are acquired, whereas in all other cases the sample moves through the scanner continuously. The difference between the continuous approaches is the trajectory by which the sample moves within the field of view. Results: All four implementation strategies are compatible with a standard table-top x-ray setup. With the experimental setup applied here, step-and-shoot acquisitions yield the best spatial resolution (around 30 µm), but are the most time-consuming (1.4 h). Continuous unidirectional and back-andforth images have resolution between 30 and 40 µm, and are faster (35 min). Continuous pixel-wise images are equally time-efficient, although technical challenges caused a small loss in image quality with a resolution of about 50 µm. Conclusion:The authors show that cycloidal CT can be implemented in a variety of ways with high quality results. They believe this posits cycloidal CT as a powerful imaging alternative to more timeconsuming and less flexible methods in the field.

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Section: Resultssupporting

confidence: 92%

“…This agrees with previous results, where the in-slice resolution of the step-and-shoot approach was found to be only slightly below that of the dithered image. 7 Among the cycloidal CT images, FIG. 4.…”

Section: Resultsmentioning

confidence: 99%

Technical Note: Practical implementation strategies of cycloidal computed tomography

et al. 2021

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“…EI can be implemented with detectors with any pixel size and PSF, while allowing flexible, user-defined resolution de-coupled from focal spot and detector characteristics, as this is determined by the apertures in the pre-sample mask [ 57 ]. While in principle reaching aperture-driven resolution requires dithering, which lengthens acquisitions and is not compatible with flyscans, the recently developed cycloidal CT method, in which the sample is roto-translated in a structured beam, offers a possible solution [ 109 ]. Finally, the use of a pre-sample absorbing mask makes it easy to keep the delivered dose under control [ 62 , 68 ].…”

Section: Edge-illumination In the Context Of Other X-ray Phase Contrast Imaging Techniques Implemented With Laboratory Sourcesmentioning

confidence: 99%

Edge-illumination x-ray phase-contrast imaging

Olivo¹

2021

J. Phys.: Condens. Matter

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Although early demonstration dates back to the mid-sixties, x-ray phase-contrast imaging (XPCI) became hugely popular in the mid-90s, thanks to the advent of 3rd generation synchrotron facilities. Its ability to reveal object features that had so far been considered invisible to x-rays immediately suggested great potential for applications across the life and the physical sciences, and an increasing number of groups worldwide started experimenting with it. At that time, it looked like a synchrotron facility was strictly necessary to perform XPCI with some degree of efficiency—the only alternative being micro-focal sources, the limited flux of which imposed excessively long exposure times. However, new approaches emerged in the mid-00s that overcame this limitation, and allowed XPCI implementations with conventional, non-micro-focal x-ray sources. One of these approaches showing particular promise for ‘real-world’ applications is edge-illumination XPCI: this article describes the key steps in its evolution in the context of contemporary developments in XPCI research, and presents its current state-of-the-art, especially in terms of transition towards practical applications.

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“…Cycloidal computed tomography 6,27 refers to an imaging concept by which the abovementioned under-sampling problem is alleviated in a different manner. Rather than step-scanning the sample for each rotational position, as is done in dithering, the sample is translated as it rotates.…”

Section: Cycloidal Computed Tomographymentioning

confidence: 99%

“…We have developed a new acquisition method ("cycloidal CT") by which our scanners' resolution could potentially be increased without extending scan time 6 . In this method, the sample is translated in the lateral plane as it rotates, which alleviates the under-sampling imposed by the beamlets.…”

Section: Introductionmentioning

confidence: 99%

Exploring the potential of cycloidal computed tomography for advancing intraoperative specimen imaging

Morgó

Massimi

Suaris

et al. 2021

Developments in X-Ray Tomography XIII

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A preliminary investigation into the use of cycloidal computed tomography for intraoperative specimen imaging is presented. Intraoperative imaging is applied in time-sensitive clinical settings, where obtaining a high-resolution, highquality image within minutes is paramount in evaluating the success of operations and/or the need for additional surgery. As a flexible imaging method that is compatible with x-ray phase contrast imaging, cycloidal computed tomography can provide both high spatial resolution and high image contrast, whilst keeping scan times short thanks to an effective under-sampling approach. To gather early evidence, the method was tested on resected breast and oesophageal tissue. The results, although preliminary, indicate that cycloidal imaging may indeed be beneficial for intraoperative specimen imaging, although further studies are required to confirm this potential.

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Cycloidal Computed Tomography

Cited by 23 publications

References 24 publications

Technical Note: Practical implementation strategies of cycloidal computed tomography

Technical Note: Practical implementation strategies of cycloidal computed tomography

Edge-illumination x-ray phase-contrast imaging

Exploring the potential of cycloidal computed tomography for advancing intraoperative specimen imaging

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