Cyclometallated gold(III) complexes against colon cancer. X-ray structure of [Au(C,NPhenylpyridine)(OAc)2]

The Ca2+-ATPase Inhibition Potential of Gold(I, III) Compounds

“…Thus, it was described that several inorganic compounds and complexes present Ca 2+ -ATPases IC 50 inhibition values globally not so different from the above well-known Ca 2+ -ATPases drugs inhibitors, for example decavanadate (IC 50 = 15 µM), polyoxotungstates (IC 50 = 0.3-200 µM), polyoxovanadates (IC 50 =1 µM), and vanadium complexes such as BMOV (IC 50 = 40 µM), among others [31][32][33][34][35]. In summary, both gold(I) and gold(III) compounds 1-4 are strong inhibitors of the SR Ca 2+ -ATPase, pointing out this enzyme as a putative target for gold compounds with anticancer activity, described as promising agents for the future in medicinal chemistry [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]23,29,[42][43][44].…”

Selective Anticancer and Antimicrobial Metallodrugs Based on Gold(III) Dithiocarbamate Complexes

“…As can be observed in Table 4 , great results were accomplished since most of our complexes showed a higher antiproliferative effect on tumor cells than cisplatin (IC 50 = 45.60 ± 8.08 µM), auranofin (IC 50 = 2.10 ± 0.40 µM) [ 27 ], and some other dithiocarbamates reported on [ 27 ]. The DTC group seemed to play a crucial role in the complexes to exhibit this cytotoxicity, as the cyclometalated precursors did not alter Caco-2 normal or tumor cell viability [ 17 ]. However, something to be remarkable is that our complexes exhibited excellent selectivity, 4.5–8.8-fold higher for tumor than normal cells, and especially complex C5 , which seemed to not alter cell proliferation of normal cells up to 100 µM, with a selectivity at least 48.3 times higher for cancer cells.…”

“…This problem has been solved in the literature by the coordination of multidentate ligands to the gold center and therefore, cyclometallation is a good strategy to enhance their stability. Several cyclometalating ligands exist, where C^N is especially interesting due to the possibility of coordinating different ancillary ligands to optimize the final drug design [ 17 , 18 , 19 , 20 ]. In the literature, several examples of cyclometalated gold(III) complexes with (C^N), (N^N^C), or (C^N^C) ligands have been studied [ 21 ], showing promising antitumor properties.…”

Synthesis of substituted (N,C) and (N,C,C) Au(iii) complexes: the influence of sterics and electronics on cyclometalation reactions

“…15 N NMR spectroscopic studies of cyclometalated Au(III) complexes Some of the complexes and ligands discussed herein were investigated by 15 N NMR spectroscopy, and coordination shifts Δδ 15 N (δ 15 N complex -δ 15 N ligand ) were obtained in order to gain insight about the Au-N interactions. Furthermore, a selection of previously reported tpy-ligated Au(III) complexes 8,14,19,22,25,95 with varying substituents cis and trans to pyridine-N was studied by 15 N NMR spectroscopy to shed light on which factors influence the 15 N NMR chemical shifts of N-ligated square planar d 8 metal complexes (Fig. 6).…”

“…(N,C)-Cyclometalated Au(III) complexes [1][2][3][4] have found application within catalysis [5][6][7][8][9] and medicine [10][11][12][13][14][15] and have also gained attention for their photophysical properties. 3,4,[16][17][18] While cyclometalated Au(III) dichloro complexes have been known since the 1980s, 1 corresponding acetate and trifluoroacetate complexes are less studied.…”