Cyclooxygenase-2 inhibitory effects and composition of the volatile oil from the dried roots of Lithospermum erythrorhizon

Abstract

The composition of the volatile oil from Lithospermi Radix, the dried roots of Lithospermum erythrorhizon (Boraginaceae), has been investigated by capillary GC and GC-MS. To investigate the anti-inflammatory activity of the oil, in-vitro inhibition of ovine cyclooxygenase-1 and 2 (COX-1 and COX-2) activity by the oil was studied. Fifty-four components of the oil were identified, representing 92.74% of the oil. The main components were 2-methylbutanoic acid (21.50%), 3-methylbutanoic acid (12.61%), 2-methylpropanoic acid (8.99%), methyl linoleate (8.76%), methyl oleate (6.27%), methyl palmitate (6.06%), and 2-methyl-2-butenoic acid (5.74%). Highly selective COX-2 inhibition was observed; at 50 microg/ml the oil inhibited 38.8% of COX-2 activity.

Antimicrobial and Cytotoxic Isohexenylnaphthazarins from Arnebia euchroma (Royle) Jonst. (Boraginaceae) Callus and Cell Suspension Culture

“…Apart from naphthoquinone pigments, linoleic acid [ 17 ] and β-sitosterol [ 18 ] have been identified in both in vitro cultures. Additionally, methyl linolate [ 17 ] has been isolated from the cell suspension culture (also detected by GC-MS in the roots of other Boraginaceous species [ 19 , 20 ]) as well as methyl jasmonate ( 10 ) [ 21 , 22 ] (for the first time within the Boraginaceae family), a triglyceride mixture of palmitic, stearic and 8- Ζ - or 9- Ζ - or 11- Ζ or 9- Ε -octadecenoic acid (as determined after transesterification/methylation and GC-MS analysis of the resulting fatty acid methyl esters [ 23 ]) and also a mixture of 1-monoglycerides of palmitic, stearic and oleic acid (as determined after transesterification/methylation and GC-MS analysis of the resulting fatty acid methyl esters [ 23 ], as well as after GC-MS analysis of the silylated derivatives which were identified as 2,3- O -bis(trimethylsilyl)-1-glyceryl palmitate, stearate and oleate respectively) probably for the first time within Boraginaceae family.…”

Aromatherapy in the treatment of rosacea induced by Helicobacter pylori

“…owing to a wide range of various biological effects, aromatherapy may be a favourable alternative in the prevention and treatment of infections. Essential oils and their terpene components are proved to have antibacterial, antiviral, antifungal, antiparasitic, and anti-inflammatory effects [40,[48][49][50]. despite the fact that numerous studies confirm the bactericidal impact of essential oils, they still remain in the shadow of pharmacological treatments and have only an adjunctive role.…”

Volatile Composition and Sensory Properties of Indian Herbal Medicine-Pavonia odorata-used in Ayurveda

“…Based on the FD-factors, it was found that β-caryophyllene oxide 60; FD-factor 128, spicy was the most intense (Tronto, Canada); Other, reference mass spectrum and retention index were measured outside the author' s laboratory (the identification is therefore considered to be tentative). e Our previous studies: 21 from miyazawa et al 14) ; 45, 47 from miyazawa et al 15) ; 56 from miyazawa et al 16) ; 63, 64, 73, 77 and 85 from miyazawa et al 17,18) ; 66 from miyazawa et al 19)…”

“…In contrast, ageratochromene, h e x a h y d r o f a r n e s y l a c e t o n e , β -e u d e s m o l , a n d β-caryophyllene oxide were identified for the first time in this study as the components of the volatile oil from the aerial parts of P. odorata. Hexahydrofarnesyl acetone is a component of volatile oils found in many plants of families such as Fabaceae 19 , Rosaceae 25 , and Asteraceae 26 . In addition, muurolane 68; 0.90 is an unusual sesquiterpene and was identified as a characteristic compound in Malvaceae for the first time.…”