Cyclooxygenase-2 Inhibitory Phenylbutenoids from the Rhizomes of Zingiber cassumunar

Han, Ah Reum; Kim, Moon Sun; Jeong, Yeon Hee; Lee, Sang Kook; Seo, Eun Kyoung

doi:10.1248/cpb.53.1466

Cited by 50 publications

(41 citation statements)

References 18 publications

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“…Plai oil contains more active compounds and has various functions, for example, DMPBD 40 and phenylbutenoids inhibit COX-2 activity. 41 Furthermore, a study by Chaiyana et al also reported that sabinene and terpinene-4-ol could reduce the expression of nuclear factor-kappa and interleukin-6 released in human peripheral blood mononuclear cells, which reflected the compounds' anti-inflammatory activity. 18 Unfortunately, this study did not evaluate the effect of application of neurofen and Plai oil on anti-inflammatory pathways, which may be studied more in the future.…”

mentioning

confidence: 97%

Anti-inflammatory activity of niosomes entrapped with Plai oil (Zingiber cassumunar Roxb.) by therapeutic ultrasound in a rat model

Leelarungrayub¹,

Manorsoi²,

Manorsoi³

2017

IJN

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mentioning

confidence: 97%

Anti-inflammatory activity of niosomes entrapped with Plai oil (Zingiber cassumunar Roxb.) by therapeutic ultrasound in a rat model

Leelarungrayub¹,

Manorsoi²,

Manorsoi³

2017

IJN

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“…Nevertheless, the inside mechanisms of these two compounds may not be similar. Dexamethasone has been reported to strongly suppress prostaglandin E2 production, (Newton et al, 1998) while compound D has no inhibitory effect on lipopolysaccharide-induced prostaglandin E2 synthesis (Han et al, 2005). This indicates that the antiinflammatory effect of compound D is not involved in the cyclooxygenase pathway.…”

Section: Resultsmentioning

confidence: 98%

Active Compound of Zingiber Cassumunar Roxb. Down-Regulates the Expression of Genes Involved in Joint Erosion in a Human Synovial Fibroblast Cell Line

Chaiwongsa

Ongchai²,

Boonsing³

et al. 2012

Afr. J. Trad. Compl. Alt. Med.

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Rheumatoid arthritis (RA) is a chronic inflammatory disease of the synovium. It is involved in up-regulation of pro-inflammatory cytokines and matrix metalloproteinases (MMPs), resulting in joint inflammation and erosion. Zingiber cassumunar Roxb. has long been used to reduce joint pain and inflammation. This study aimed to investigate the inhibitory activities of an active compound of Z. cassumunar, (E)-4-(3',4'-dimethoxyphenyl)but-3-en-1-ol (compound D), against cytokine-induced up-regulation of catabolic genes involved in cartilage degradation in RA. Synovial fibroblast cell line, SW982, was cultured in media containing interleukin-1ß (IL-1ß), in the presence or absence of compound D at the concentration range of 1 to 100 µM. After 24 hours, the cells were analyzed for the expressions of MMPs, IL-1ß and interleukin-1ß-converting enzyme (ICE) by RT-PCR. MMPs activities in the culture media were analyzed by zymographic techniques. Dexamethasone was used as the positive control. It was found that compound D at the concentration of 10 -100 M significantly decreased the mRNA expressions of MMP-1, -2, -3, and -13 which was induced by IL-1ß (P<0.05) concomitantly with a decrease in activities of these MMPs in the culture media. An increase in the mRNA expression of IL-1ß and ICE was also suppressed by compound D. The results suggest that the potent activities of this compound may be involved in the reduction of IL-1ß protein synthesis in both pro-form and active form which played an important role in up-regulation of MMPs. This study first revealed the chondroprotective activity of Z. cassumunar in the transcriptional level by suppressing cytokine-induced catabolic genes which caused cartilage erosion in RA.

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“…1. Zingiber cassumunar has been reported with IC 50 (inhibition concentration at 50%) values against COX-2, ranging from 2.71 to 20.98 µM (Han, 2005). The first two compounds are structurally related to phenyl propane, which are 4-(3,4-dimethoxy-phenyl)but-1,3-diene (DMPBD), 4-[2,4,5-trimethoxy-phenyl)but-1,3-diene (TMPBD), and showed high IC 50 of 14.97 and 20.68 µM, respectively (Fig.…”

Section: Chemical Constituents and Anti-inflammatory Activity Of Prasmentioning

confidence: 99%

Prasaplai: An essential Thai traditional formulation for primary dysmenorrhea treatment

Tangyuenyongwatana¹,

Gritsanapan²

2014

TANG [HUMANITAS MEDICINE]

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Affecting more than half of menstruating women, dysmenorrhea is a cramp which causes abdominal or lower back pain just before or during a menstruation. In western medicine, non-steroidal antiinflammatory drugs (NSAIDs) are normally used to treat primary dysmenorrheal symptoms. Despite their rapidity in relieving pain, NSAIDs have many serious side effects on the liver, kidney, and gastrointestinal tract. Thai traditional medicines comprise many preparations for treating dysmenorrhea, especially Prasaplai preparation which has been listed in the Thai traditional common household drug list since 2006. The use of Prasaplai was originated about 100 years ago and is still being used in the present time to treat dysmenorrhea. This review focuses on the history of the preparation, active ingredients, and biological activities especially on cyclooxygenase inhibitor, artifacts occurred in the preparation, quantitative analysis, and clinical trial of Prasaplai formulation.

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Cyclooxygenase-2 Inhibitory Phenylbutenoids from the Rhizomes of Zingiber cassumunar

Cited by 50 publications

References 18 publications

Anti-inflammatory activity of niosomes entrapped with Plai oil (<em>Zingiber cassumunar</em> Roxb.) by therapeutic ultrasound in a rat model

Anti-inflammatory activity of niosomes entrapped with Plai oil (<em>Zingiber cassumunar</em> Roxb.) by therapeutic ultrasound in a rat model

Active Compound of <em>Zingiber Cassumunar</em> Roxb. Down-Regulates the Expression of Genes Involved in Joint Erosion in a Human Synovial Fibroblast Cell Line

Prasaplai: An essential Thai traditional formulation for primary dysmenorrhea treatment

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