Cyclooxygenase-2, P53 and Glucose Transporter-1 as Predictors of Malignancy in the Development of Gallbladder Carcinomas

Legan, Mateja

doi:10.17305/bjbms.2010.2684

Cited by 17 publications

(18 citation statements)

References 6 publications

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“…The expression of COX-2 is induced by several stimuli, including growth factors, inflammation and cytokines. COX-2 is upregulated in numerous types of cancer (34). EGFR is the cell-surface receptor for epidermal growth factors and is a growth factor involved in the regulation of cell growth, proliferation and differentiation.…”

Section: Discussionmentioning

confidence: 99%

Correlation among 16 biological factors [p53, p21waf1, MIB-1 (Ki-67), p16INK4A, cyclin D1, E-cadherin, Bcl-2, TNF-α, NF-κB, TGF-β, MMP-7, COX-2, EGFR, HER2/neu, ER, and HIF-1α] and clinical outcomes following curative chemoradiation therapy in 10 patients with esophageal squamous cell carcinoma

et al. 2013

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The expression levels of 16 proteins were analyzed to identify prognostic correlations in esophageal squamous cell carcinoma (ESCC) treated with concurrent chemoradiation therapy (CCRT). The immunohistochemical expression levels of p53, p21waf1, molecular immunology borstel-1 (MIB-1, Ki-67), p16INK4A, cyclin D1, E-cadherin, Bcl-2, tumor necrosis factor (TNF)-α, nuclear factor (NF)-κB, transforming growth factor (TGF)-β, matrix metalloproteinase (MMP)-7, cyclooxygenase (COX)-2, epidermal growth factor receptor (EGFR), human EGFR type 2 (HER2/neu), estrogen receptor (ER) and hypoxia-inducible factor (HIF)-1α were studied in 10 cases of ESCC treated with CCRT. The patients underwent CCRT between 2000 and 2010. The mean patient age was 68.1 years (range, 46-80 years). The numbers of patients in stages I, II, III and IV of the disease were 2, 2, 3 and 3, respectively. Of the tumors, 8 were positive for p53, 6 for p21waf1, 7 for MIB-1 (Ki-67), 7 for p16INK4A, 7 for cyclin D1, 8 for E-cadherin, 3 for Bcl-2, 0 for TNF-α, 5 for NF-κB, 7 for TGF-β, 9 for MMP-7, 7 for COX-2, 5 for EGFR, 1 for HER2/neu, 1 for ER and 7 for HIF-1α. The 2-year overall survival rate of patients expressing high levels of MIB-1 was 71% (±17%) compared with 0% (P=0.019) for those expressing low levels. For NF-κB, the rate was 0% for patients with high levels compared with 100% (P<0.018) for those with low levels. The 2-year local control rates of HER2/neu were 0% in patients expressing high levels and 88% (±12%) in patients expressing low levels (P=0.027). The 2-year disease-free survival rates of HER2/neu and ER were 0% for patients expressing high levels compared with 56% (±17%) for those with low levels (P=0.027). There were no significant correlations between the expression levels of the other proteins and clinical outcomes. In the present study, high levels of MIB-1 and low levels of NF-κB, HER2 and ER were shown to be good prognostic factors following definitive CCRT for ESCC.

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Section: Discussionmentioning

confidence: 99%

Correlation among 16 biological factors [p53, p21waf1, MIB-1 (Ki-67), p16INK4A, cyclin D1, E-cadherin, Bcl-2, TNF-α, NF-κB, TGF-β, MMP-7, COX-2, EGFR, HER2/neu, ER, and HIF-1α] and clinical outcomes following curative chemoradiation therapy in 10 patients with esophageal squamous cell carcinoma

et al. 2013

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“…(1) patients with histological diagnosis of GBC; (2) GBC patients with no other coexisting malignancies; (3) patients not receiving other treating processes before recruitment; (4) patients with available follow-up data and overall clinical data: and (5) patients aged >18 years. The exclusion criteria included (1) patients exhibiting acute infection or chronic active inflammatory disease; (2) patients with anemia, collagen diseases and others regarding the hematological mechanism; (3) patients having taken anticoagulant treatment or albumin transfusions before receiving the treatment; (5) patients exhibiting perioperative surgery-associated mortality. Clinical data within 30 days before surgery for 202 of the patients were included.…”

Section: Methodsmentioning

confidence: 99%

“…Gallbladder cancer (GBC) has been the commonest malignant biliary tract tumor, taking up 80%-95% of biliary cancer patients [1]. CBG refers to the fifth commonest malignancy of the gastrointestinal tract, taking up ~ 1% of all cancers in our nation [2]. Because of insufficient effective diagnostic markers, single treatment choices, late diagnosis, and atypical symptoms, the prognosis of GBC remains ineffective [3].…”

Section: Introductionmentioning

confidence: 99%

Preoperative Geriatric Nutritional Risk Index is an independent prognostic factor for postoperative survival after Gallbladder carcinoma radical surgery

Zhang

2020

Preprint

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Background Surgical results of gallbladder cancer (CBG) are currently inadequate. The Geriatric Nutritional Risk Index (GNRI) can effectively assess nutritional status. The present study attempted to delve into investigating whether preoperative GNRI can act as a predicting factor for CBG. Methods 202 consecutive GBC patients treated from 2010 to 2017 were taken retrospectively. By conducting univariate and multivariate Cox regression analyses on overall survival (OS) and recurrence-free survival (RFS), their preoperative GNRI was studied. Results Of the 202 patients, 103 (51.0%) had GNRI<100. The patients with low GNRI before surgery had the median OS of 26 months, less than that of patients having received high GNRI before surgery (39 months, P<0.001). GNRI displayed associations with less survival times in univariate (HR, 3.656; 95%CI, 2.308-5.790; P<0.001). As indicated from the results of multivariate analysis, patients exhibiting low GNRI showed a lower OS (HR, 2.386; 95%CI, 1.170-4.868; P=0.017) and RFS (HR, 7.610; 95%CI, 3.181-18.207; P<0.001) than those exhibiting high GNRI. Conclusions GNRI is an independent indicator of poor prognosis in GBC patients after GBC radical surgery.

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“…A decrease in the expression of hMLH1 and hMSH2 occurs in patients with adenomas and adenocarcinomas. The decrease in the expression of hMLH1 was observed in patients with microsatellite instability (MSI) in CRC [28]. So, inactivation of the genes taking part in MMR lead to MSI in CRC.…”

Section: Influence Of Genetic Mutation In Neoplasia Of Colorectal Cancermentioning

confidence: 99%

“…The expression level of COX-2 is elevated in many cancers (e.g. in gallbladder carcinomas along with increased angiogenesis) [28]. PGH 2 , the product of COX-2, is converted by prostaglandin E2 synthase into prostaglandin E2 (PGE 2 ), which can stimulate cancer progression.…”

Section: Expression Of Cyclooxygenase-2 In Serrated Adenomas Non-sermentioning

confidence: 99%

Large Bowel Genetic Background and Inflammatory Processes in Carcinogenesis – Systematic Review

Szylberg¹,

Janiczek²,

Popiel³

et al. 2016

Adv Clin Exp Med

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Colorectal cancer (CRC) has become the third most common cancer in developed countries. Each year more and more people die from CRC. CRC is also one of the most effectively studied topics in recent years. It has been found that the key phenomena in CRC development are genetic and inflammatory processes. Well-known genetic bases for the carcinogenesis of CRC include chromosomal changes characteristic of the chromosomal instability pathway which correlates with specific and well-defined genetic alterations (such as APC, K-RAS, DCC and p53) and genomic instability characteristics for the mutator pathway focused on KRAS and BRAF mutations. Recent studies have highlighted the impact of inflammation in CRC, especially elevated levels of pro-inflammatory cytokines. Among important risk factors of colon carcinogenesis are colorectal polyps, which are currently the subject of intense research. Recent studies have shown that different adenomas are characterized by different pathways of carcinogenesis as well as diverse COX-2 expression in various polyps. Understanding the mechanism of inflammatory processes in CRC parallel to basic genetic alterations might allow for effective and targeted treatment (Adv Clin Exp Med 2015, 24, 4, 555-561).

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Cyclooxygenase-2, P53 and Glucose Transporter-1 as Predictors of Malignancy in the Development of Gallbladder Carcinomas

Cited by 17 publications

References 6 publications

Correlation among 16 biological factors [p53, p21waf1, MIB-1 (Ki-67), p16INK4A, cyclin D1, E-cadherin, Bcl-2, TNF-α, NF-κB, TGF-β, MMP-7, COX-2, EGFR, HER2/neu, ER, and HIF-1α] and clinical outcomes following curative chemoradiation therapy in 10 patients with esophageal squamous cell carcinoma

Correlation among 16 biological factors [p53, p21waf1, MIB-1 (Ki-67), p16INK4A, cyclin D1, E-cadherin, Bcl-2, TNF-α, NF-κB, TGF-β, MMP-7, COX-2, EGFR, HER2/neu, ER, and HIF-1α] and clinical outcomes following curative chemoradiation therapy in 10 patients with esophageal squamous cell carcinoma

Preoperative Geriatric Nutritional Risk Index is an independent prognostic factor for postoperative survival after Gallbladder carcinoma radical surgery

Large Bowel Genetic Background and Inflammatory Processes in Carcinogenesis – Systematic Review

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