Cyclopeptide alkaloids

Abstract

Antibacterial activity 7.3 Antifungal activity 8 Biosynthesis: tissue culture 9 Conclusions 10 References 1 Introduction Cyclopeptide alkaloids are defined as basic compounds embodying an ansa structure, in which a 10-or 12-membered peptide-type bridge spans the 1,3 or 1,4 positions of a benzene ring.' They are widely distributed among plants of the Rhamnaceae family, but their occurrence has also been confirmed in representatives of Asteraceae, Celastraceae, Euphorbiaceae, Menispermaceae, Pandaceae, Rubiaceae, Sterculiaceae and Urticaceae. The general structure of cyclopeptide alkaloids is designated in Fig. 1.

Stereoselective Hydrogenation ofCCBonds: Application to Drug and Natural Product Synthesis

“…231 Adamczyk and co-workers set out to develop a straightforward access to enantioenriched (S)-(À)-acromelobinic 232 and (S)-(À)-acromelobic 233 acids to achieve elaboration of asymmetric hydrogenation of dehydroamino acid derivatives 145 and 147 (Scheme 29.10). 234 The dehydroamino acid derivative 145 was hydrogenated in the pres- Cyclopeptide alkaloids 235,236 belong to a class of natural products widely distributed among plants of the Rhamnaceae family, 237 but their occurrence has also been confirmed in representatives of Celastraceae, 238 antifungal, sedative, and antiplasmodial. 239 Both abyssenine A and murconine E were isolated from the roots and stem bark of several Zizyphus-type Rhamnaceae.…”

Cyclopeptide alkaloids

“…In a previous review article, Gournelis et al (1997) classified the cyclopeptide alkaloids according to the size of the macrocycle to: 13-, 14-, or 15-membered ring compounds, which are further divided according to the number of the amino acid units to: 4(13-), 5(13-), 4(14-), 5(14-), and 5(15-). Where (4) means constituted of four different subunits A, B, C, and D, and (5), having unites A, B, C, D, and E. A: a basic terminal end amino acid, B: a b-hydroxy amino acid, C: a ringbond amino acid, and D is the hydroxystyrylamine unit.…”

“…Cyclopeptide alkaloids are polyamidic bases, widely distributed among plants of many families like Rhamnaceae, Asteraceae, Celastraceae, Euphorbiaceae, Menispermaceae, Pandaceae, Rubiaceae, Sterculiaceae, and Urticaceae (Gournelis et al 1997). Recently we isolated and structure-elucidated some cyclopeptide alkaloids for the first time from the family Olacaceae (El-Seedi et al 1999.…”

Biomimetic Synthesis of Azole‐ and Aryl‐Peptide Alkaloids

“…Although various biological activities such as antibacterial, antifungal, sedative, and immunostimulant properties have been identified for these compounds, detailed understanding about their biological function and their biosynthesis still needs to be developed [58]. However, their likely precursors are oligopeptides.…”