Antibacterial activity 7.3 Antifungal activity 8 Biosynthesis: tissue culture 9 Conclusions 10 References 1 Introduction Cyclopeptide alkaloids are defined as basic compounds embodying an ansa structure, in which a 10-or 12-membered peptide-type bridge spans the 1,3 or 1,4 positions of a benzene ring.' They are widely distributed among plants of the Rhamnaceae family, but their occurrence has also been confirmed in representatives of Asteraceae, Celastraceae, Euphorbiaceae, Menispermaceae, Pandaceae, Rubiaceae, Sterculiaceae and Urticaceae. The general structure of cyclopeptide alkaloids is designated in Fig. 1.

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SummarySolid phase extraction (SPE) methods are studied for the sample pretreatment for HPLC analysis of Taxus cell suspension cultures. Various types of SPE materials were tested for the extraction of both the taxane standards and samples of various origin. Comparison between the different cartridges and the different elution solvents are made in terms of extraction recovery and sample clean-up. Selective elution of the taxanes is achieved by a gradient elution scheme.