Corrigendum

Gournelis, Dimitris C.; Laskaris, Gregory; Verpoorte, Robert

doi:10.1039/np9971400432

Cited by 2 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In case of the erythro form, a J value of 8 Hz is typical, while the threo form exhibits a smaller J value of approximately 2 Hz. 2 For oxyphylline-C, the L-erythro form has been reported before (J8-9 7.2 Hz). 6 Here, both oxyphylline-C (7) and the new compound, oxyphylline-F (9) were found to contain L-erythro-β-hydroxy-phenylalanine, since they showed J8-9 values of 7.2 and 8.4 Hz, respectively.…”

Section: Resultsmentioning

confidence: 62%

“…Oxyphyllines-C (7), -E (8) and -F ( 9) are so-called neutral cyclopeptide alkaloids, in which the basic amino acid in the side-chain is missing, and contain a cinnamoyl moiety instead. 2 Neutral cyclopeptide alkaloids are relatively rare. Until now, only fifteen representatives have been reported and all of them were found to contain a 14-membered macrocyclic ring.…”

Section: Resultsmentioning

confidence: 99%

“…Nine cyclopeptide alkaloids (1)(2)(3)(4)(5)(6)(7)(8)(9), of which five (compounds 2, 3, 5, 8 and 9,) are described herein for the first time, were isolated from roots of Ziziphus oxyphylla by means of conventional separation methods as well as semi-preparative HPLC with DAD and ESIMS detection and LC-DAD-SPE-NMR. Structure elucidation was done by spectroscopic means.…”

Section: Introductionmentioning

confidence: 99%

“…In this manner, the 4(13)-, 4(14)-, 5(13)-, and 5(14)-cyclopeptide alkaloid subclasses are distinguished. 1,2 Ziziphus oxyphylla Edgew. (Rhamnaceae) is a small-to medium-sized tree that grows in the northern regions of Pakistan.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Isolation and Structure Elucidation by LC-DAD-MS and LC-DAD-SPE-NMR of Cyclopeptide Alkaloids from the Roots of Ziziphus oxyphylla and Evaluation of Their Antiplasmodial Activity

et al. 2016

View full text Add to dashboard Cite

Nine cyclopeptide alkaloids (1-9), of which five (compounds 2, 3, 5, 8, and 9) are described herein for the first time, were isolated from roots of Ziziphus oxyphylla by means of conventional separation methods as well as semipreparative HPLC with DAD and ESIMS detection and LC-DAD-SPE-NMR. Structure elucidation was done by spectroscopic means. Nummularine-R (1), a previously known constituent from this species, was isolated along with its new derivatives O-desmethylnummularine-R (2) and O-desmethylnummularine-R N-oxide (3). In addition, the known compounds hemsine-A (4) and ramosine-A (6), as well as hemsine-A N-oxide (5), were isolated. Moreover, oxyphylline-C (7), a known constituent of Z. oxyphylla stems, was obtained, and two new compounds were identified, oxyphyllines-E (8) and -F (9). Just like oxyphylline-C, oxyphyllines-E and -F belong to the relatively rare class of neutral cyclopeptide alkaloids. The antiplasmodial activity and cytotoxicity of compounds 1, 2, 4, 6, and 9 were evaluated, and the most promising activity was found for O-desmethylnummularine-R (2), which exhibited an IC value of 3.2 ± 2.6 μM against Plasmodium falciparum K1, whereas an IC value of >64.0 μM was evident for its cytotoxicity against MRC-5 cells.

show abstract

Section: Resultsmentioning

confidence: 62%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Isolation and Structure Elucidation by LC-DAD-MS and LC-DAD-SPE-NMR of Cyclopeptide Alkaloids from the Roots of Ziziphus oxyphylla and Evaluation of Their Antiplasmodial Activity

et al. 2016

View full text Add to dashboard Cite

show abstract

“…They consist of a styrylamine unit and three or four amino acids as common structural elements. 10,11 ■ RESULTS AND DISCUSSION The root bark of H. acida was extracted with 80% methanol, and the crude extract was fractionated by liquid−liquid partitioning, followed by flash chromatography. The isolation of single compounds was performed with semipreparative HPLC with DAD and ESIMS detection, and in this way four cyclopeptide alkaloids were obtained (1-4).…”

mentioning

confidence: 99%

Cyclopeptide Alkaloids from Hymenocardia acida

Tuenter¹,

Exarchou²,

Baldé

et al. 2016

J. Nat. Prod.

View full text Add to dashboard Cite

Four cyclopeptide alkaloids (1-4) were isolated from the root bark of Hymenocardia acida by means of semipreparative HPLC with DAD and ESIMS detection and conventional separation methods. Structure elucidation was performed by spectroscopic means. In addition to the known compound hymenocardine (1), three other alkaloids were isolated for the first time from a natural source. These included a hymenocardine derivative with a hydroxy group instead of a carbonyl group that was named hymenocardinol (2), as well as hymenocardine N-oxide (3) and a new cyclopeptide alkaloid containing an unusual histidine moiety named hymenocardine-H (4). The isolated cyclopeptide alkaloids were tested for their antiplasmodial activity and cytotoxicity. All four compounds showed moderate antiplasmodial activity, with IC50 values ranging from 12.2 to 27.9 μM, the most active one being hymenocardine N-oxide (3), with an IC50 value of 12.2 ± 6.6 μM. Compounds 2-4 were found not to be cytotoxic against MRC-5 cells (IC50 > 64.0 μM), but hymenocardine (1) showed some cytotoxicity, with an IC50 value of 51.1 ± 17.2 μM.

show abstract

Corrigendum

Cited by 2 publications

References 0 publications

Isolation and Structure Elucidation by LC-DAD-MS and LC-DAD-SPE-NMR of Cyclopeptide Alkaloids from the Roots of Ziziphus oxyphylla and Evaluation of Their Antiplasmodial Activity

Isolation and Structure Elucidation by LC-DAD-MS and LC-DAD-SPE-NMR of Cyclopeptide Alkaloids from the Roots of Ziziphus oxyphylla and Evaluation of Their Antiplasmodial Activity

Cyclopeptide Alkaloids from Hymenocardia acida

Contact Info

Product

Resources

About