Cyclophosphamide-induced Cardiotoxicity with a Prolonged Clinical Course Diagnosed on an Endomyocardial Biopsy

Kusumoto, Saburo; Kawano, Hiroaki; Hayashi, Tomayoshi; Satoh, Osami; Yonekura, Tsuyoshi; Eguchi, M.; Takeno, Masayoshi; Tsuneto, Akira; Koide, Yuji; Jo, Tatsuro; Maemura, Koji

doi:10.2169/internalmedicine.52.0347

Cited by 17 publications

(10 citation statements)

References 11 publications

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“…Cyclophosphamide-induced cardiac damage is dosedependent and the total dose of an individual course is the best indicator of toxicity; patients who receive greater than 150 mg/kg or 1.55 g/m2/day are at high risk for cardiotoxicity [10]. Cardiotoxicity is a dose-limiting factor during cyclophosphamide therapy [11].…”

Section: Introductionmentioning

confidence: 99%

Cardioprotective Effect of Croton macrostachyus Stem Bark Extract and Solvent Fractions on Cyclophosphamide‐Induced Cardiotoxicity in Rats

Ayza

Balasubramanian²,

Berhe

2020

Evidence-Based Complementary and Alternative Medicine

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Context. Croton macrostachyus Hochst. ex Delile (Euphorbiaceae) has been used in traditional medicine to manage heart failure and other heart diseases in Ethiopia. Objective. To evaluate the antioxidant and cardioprotective activities of stem bark extract and solvent fractions of Croton macrostachyus on cyclophosphamide-induced cardiotoxicity in rats. Materials and Methods. DPPH free radical scavenging assay method was used to determine antioxidant activity whereas Sprague-Dawley rats were used to evaluate the cardioprotective activity. Except for the normal control, all groups were subjected to cyclophosphamide (200 mg/kg, i.p.) toxicity on the first day. Enalapril at 10 mg/kg was used as a reference. The hydromethanolic crude extract (100, 200, and 400 mg/kg) and aqueous and ethyl acetate fractions (100 and 200 mg/kg, each) were administered for 10 days. The cardioprotective activities were evaluated using cardiac biomarkers such as Troponin I, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total cholesterol (TC), triglyceride (TG), and histopathological studies of heart tissue. Results. Crude extract and ethyl acetate and aqueous fractions exhibited free radical scavenging activities at IC50 of 594 μg/mL, 419 μg/mL, and 716 μg/mL, respectively. Crude extract at 400 mg/kg decreased the levels of troponin, AST, ALT, and ALP to 0.29 ± 0.06 ng/mL, 103.00 ± 7.63 U/L, 99.80 ± 6.18 U/L, and 108.80 ± 8.81 U/L, respectively. In addition, ethyl acetate fraction at 200 mg/kg decreased the levels of troponin, AST, ALT, and ALP to 0.22 ± 0.02 ng/mL, 137.00 ± 14.30 U/L, 90.33 ± 6.13 U/L, and 166.67 ± 13.50 U/L, respectively, compared with the cyclophosphamide control group. Conclusions. Croton macrostachyus possesses cardioprotective activities and it could be a possible source of treatment for cardiotoxicity induced by cyclophosphamide.

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Section: Introductionmentioning

confidence: 99%

Cardioprotective Effect of Croton macrostachyus Stem Bark Extract and Solvent Fractions on Cyclophosphamide‐Induced Cardiotoxicity in Rats

Ayza

Balasubramanian²,

Berhe

2020

Evidence-Based Complementary and Alternative Medicine

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“…В комплексе с кардиомиопатией наблюдаются системная и легочная артериальная гипертензия, ухудшение функционирования печени и почек [8].…”

Section: Research Institute Of Molecular Pathology and Pathomorphologunclassified

STRUCTURAL BASIS OF MYOCARDIAL REMODELING UNDER CYCLOPHOSPHAMIDE TREATMENT WITH CORRECTION OF K+ , Mg 2+ ION EXCHANGE IN CARDIOMYOCYTES

Лушникова¹,

Клинникова²,

Nikityuk³

et al. 2016

СПНО (MPSE)

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“…Many case studies report that CP induced cardio toxicity is associated with systemic endothelial damage. 11 The present study was aimed to investigate the cardioprotective effect of different combination of Silymarin (SILY) and Quercetin (QUE) against Cyclophosphamide (CP) induced cardiotoxicity in experimental rats.…”

Section: Indroductionmentioning

confidence: 99%

Pharmacodynamic Interaction of Quercetin and Silymarin Against Cyclophosphamide Induced Cardio-Toxicity

Jithin¹,

Chakraborty²,

Kamath³

2016

Int. Res. J. Pharm.

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The study was designed to investigate the cardioprotective effect of different combination of Silymarin and Quercetin against Cyclophosphamide induced cardiotoxicity in experimental rats. The Albino rats of either sex were divided into five groups of six animals. Group 1 and group 2 served as normal and control group respectively. Other groups treated with Silymarin (60 mg/kg, p.o.) alone, high (30 mg/kg, p.o.) and low (15 mg/kg, p.o.) dose of Silymarin combined with Quercetin (10 mg/kg, p.o.). Myocardial damage was induced by the administration of Cyclophosphamide (200mg/kg, i.p.) on the first day and the treatment was conducted for ten days. Twenty-four hours after the last administration, the blood was collected by the retro-orbital puncture method and the serum biomarker level of Lactate Dehydrogenase (LDH), Creatinine Kinase-NAC (CK-NAC), Creatinine Kinase-MB (CK-MB), Aspartate Transaminase (AST), Alanine Transaminase (ALT) and Alkaline Phosphatase (ALP) in serum were evaluated. Electro-cardiograph parameters such as Heart rate, QRS interval, QT segment, PR interval and RR interval also carried out. Compared to the control group all treated group showed significant activity and high and low dose combination group showed profound cardiac protection compare to the Silymarin alone. Among the entire groups high dose combination group (SILLY30+QUE10) showed most effective Cardio-protection and was also responsible for the significant improvement in the ECG parameters.

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Cyclophosphamide-induced Cardiotoxicity with a Prolonged Clinical Course Diagnosed on an Endomyocardial Biopsy

Cited by 17 publications

References 11 publications

Cardioprotective Effect of Croton macrostachyus Stem Bark Extract and Solvent Fractions on Cyclophosphamide‐Induced Cardiotoxicity in Rats

Cardioprotective Effect of Croton macrostachyus Stem Bark Extract and Solvent Fractions on Cyclophosphamide‐Induced Cardiotoxicity in Rats

STRUCTURAL BASIS OF MYOCARDIAL REMODELING UNDER CYCLOPHOSPHAMIDE TREATMENT WITH CORRECTION OF K+ , Mg 2+ ION EXCHANGE IN CARDIOMYOCYTES

Pharmacodynamic Interaction of Quercetin and Silymarin Against Cyclophosphamide Induced Cardio-Toxicity

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