2024
DOI: 10.2174/1567201820666230410120437
|View full text |Cite
|
Sign up to set email alerts
|

Cyclophosphamide Loading and Controlled Release in MIL-100(Fe) as an Anti-breast Cancer Carrier: In vivo In vitro Study

Abstract: Background: Biocompatible MIL-100 (Fe), a metal organic framework material, has recently attracted increasing attention in biomedical engineering. The high surface area, pore volume, and accessible Lewis acid sites make MIL-100 (Fe) a proper candidate for hydrophobic anticancer drug loading and storage. In this study, a novel investigation of cyclophosphamide (CP) -loaded MIL-100(Fe) (MIL-100(Fe)/CP) and a simulation of drug loading at a molecular level is presented. Methods: This research used a facile synt… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
4
1

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(1 citation statement)
references
References 50 publications
0
1
0
Order By: Relevance
“…Therefore, the amount of foreign materials that needs to be administrated to the patient decreases, potentially reducing the treatment’s unwanted side effects. Additionally, the MOF’s diverse chemistry from its organic and inorganic counterparts allows for tunable functionalities for drug delivery. As a result of these two advantages, MOFs reported in the literature have high payloads for a wide variety of active pharmaceutical ingredients and have been applied to treat various diseases. Multiple drug-loading and surface modification strategies have been developed. Nevertheless, due to the coordinative nature of their chemical bonds, the MOFs’ in vivo applications have faced the challenge of unpredictable and nongeneralizable degradation behaviors and associated toxicity. Therefore, each type of MOF needs an individual analysis of the degradation mechanism and the nature of degradation products.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, the amount of foreign materials that needs to be administrated to the patient decreases, potentially reducing the treatment’s unwanted side effects. Additionally, the MOF’s diverse chemistry from its organic and inorganic counterparts allows for tunable functionalities for drug delivery. As a result of these two advantages, MOFs reported in the literature have high payloads for a wide variety of active pharmaceutical ingredients and have been applied to treat various diseases. Multiple drug-loading and surface modification strategies have been developed. Nevertheless, due to the coordinative nature of their chemical bonds, the MOFs’ in vivo applications have faced the challenge of unpredictable and nongeneralizable degradation behaviors and associated toxicity. Therefore, each type of MOF needs an individual analysis of the degradation mechanism and the nature of degradation products.…”
Section: Introductionmentioning
confidence: 99%