Cyclophosphamide treatment causes impairment of sperm and its fertilizing ability in mice

Elangovan, Namasivayam; Chiou, Tzeon‐Jye; Tzeng, Woan-Fang; Chu, Shao‐I

doi:10.1016/j.tox.2006.01.027

Cited by 125 publications

(140 citation statements)

References 39 publications

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“…Testis weight is connected with quantities of different differentiational spermatids (19). We found results here that were consistent with those in our previous work which indicated that CP exposure resulted in decreases in sperm count and survival ratio, an increased sperm abnormality ratio, as well as signifi cant reductions in body weight, testis weight and index in CP-treated mice, which also agreed with current data (3,4,9,20).…”

Section: Discussionsupporting

confidence: 93%

Interventional effects of squid ink polysaccharides on cyclophosphamide-associated testicular damage in mice

Le¹,

Luo²,

Gu³

et al. 2015

BLL

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Cyclophosphamide (CP) is a commonly used antitumour and immunosuppressive drug, but it is inevitable that the chemotherapeutic agent may cause long-term or permanent reproductive damage on young male patients through inducing oxidative stress in the testes. Squid ink polysaccharides (SIP), a newly found marine glycosaminoglycon have been proved to have antioxidant capabilities and chemotherapy-protective activities on model animals in our recent investigations. This study was conducted to assess whether or not SIP could protect male mice against gonadotoxicity during CP exposure. Sexually mature male Kunming mice were allocated to one of four groups. CP was abdominally administered at dose of 15 mg/kg body weight to two groups of mice for ten weeks, once a week, one group of mice received SIP at dose of 80 mg/kg body weight by gavage for ten weeks, once a day. The other two groups comprised a vehicle treated group and an SIP treated group. Toxicity of CP and protective activity of SIP on the testes were assessed by: sperm parameters, organ index, testicular antioxidant ability, activities of marker enzymes, sex hormone content, and histopathological features. Data showed CP-induced, serious negative changes on murine sperm parameters, organ index, testicular antioxidant ability, activities of marker enzymes, sexual hormone contents, and histopathological features which were all signifi cantly impaired by SIP. This study found that SIP were demonstrated to offer protective effects against CP-induced toxicity on testes in mice (Tab. 2, Fig. 3, Ref. 29). Text in PDF www.elis.sk.

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Section: Discussionsupporting

confidence: 93%

Interventional effects of squid ink polysaccharides on cyclophosphamide-associated testicular damage in mice

Le¹,

Luo²,

Gu³

et al. 2015

BLL

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“…Exposures of mice to a variety of environmental agents, including components of tobacco smoke, have been shown to affect sperm motility (Chapin et al, 1997;Elangovan et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Differential sensitivity of male germ cells to mainstream and sidestream tobacco smoke in the mouse

Polyzos

Schmid

Piña-Guzmán

et al. 2009

Toxicology and Applied Pharmacology

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Cigarette smoking in men has been associated with increased chromosomal abnormalities in sperm and with increased risks for spontaneous abortions, birth defects and neonatal death.Little is known, however, about the reproductive consequences of paternal exposure to secondhand smoke. We used a mouse model to investigate the effects of paternal exposure to sidestream (SS) smoke, the main constituent of second-hand smoke, on the genetic integrity and function of sperm, and to determine whether male germ cells were equally sensitive to mainstream (MS) and SS smoke. A series of sperm DNA quality and reproductive endpoints were investigated after exposing male mice for two weeks to MS or SS smoke. Our results indicated that: (i) only SS smoke significantly affected sperm motility; (ii) only MS smoke induced DNA strand breaks in sperm; (iii) both MS and SS smoke increased sperm chromatin structure abnormalities; and (iv) MS smoke affected both fertilization and the rate of early embryonic development, while SS smoke affected fertilization only. These results show that MS and SS smoke have differential effects on the genetic integrity and function of sperm and provide further evidence that male exposure to second-hand smoke, as well as direct cigarette smoke, may diminish a couple's chance for a successful pregnancy and the birth of a healthy baby.

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“…When the farnesol was used as a pretreatment medicine in treated groups, the amount of MDA decreased significantly in comparison with CP group (group B) but the antioxidant enzymes such as CAT and GSH increased. There is a common agreement that male reproductive organ is especially susceptible to the toxic effects of ROS and lipid peroxidation which eventually result in infertility and CP has a critical role in the production of these toxic agents (29,30). Farnesol was able to show an ameliorative effect on CP induced testicular injuries.…”

Section: Discussionmentioning

confidence: 93%

Ameliorative action of farnesol on cyclophosphamide induced toxicity in mice

Araghi¹,

Golshahi²,

Baghban³

et al. 2017

J Herbmed Pharmacol

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Cyclophosphamide treatment causes impairment of sperm and its fertilizing ability in mice

Cited by 125 publications

References 39 publications

Interventional effects of squid ink polysaccharides on cyclophosphamide-associated testicular damage in mice

Interventional effects of squid ink polysaccharides on cyclophosphamide-associated testicular damage in mice

Differential sensitivity of male germ cells to mainstream and sidestream tobacco smoke in the mouse

Ameliorative action of farnesol on cyclophosphamide induced toxicity in mice

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