Cyclophosphamide treatment expands the circulating hematopoietic stem cell pool in dogs.

Abrams, RA; McCormack, Katherine; Bowles, Charles A.; Deisseroth, AB

doi:10.1172/jci110167

Cited by 86 publications

(28 citation statements)

References 18 publications

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“…This notion is in accordance with studies of other groups in mice [49], dogs [50], and monkeys [Sl], supporting the concept that it is the role of blood stem cells to replenish the stem cell pool of hematopoietic tissue in case of a stem cell concentration deficit. This was substantiated by our previous studies in dogs.…”

Section: Stem Cell Migration To Reconstitute Hematopoiesissupporting

confidence: 91%

The role of blood stem cells in hematopoietic cell renewal

Fliedner

2009

STEM CELLS

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It has been the purpose of this keynote address to review available evidence for the notion that the stem and progenitor cells circulating in the peripheral blood play a decisive role in the homeostasis of blood cell formation distributed throughout dozens of bone marrow units in the skeleton. Furthermore, if this notion is correct, one could speculate that the quantity and quality of stem and progenitor cells in the blood should reflect the functional state of the hematopoietic stem cell system throughout the skeletal bone marrow and provide a new tool for the evaluation of alteration in blood cell production. On this basis, the following questions are considered: A) What do we know about the quality and quantity of blood stem cells in steady state conditions? B) In what way do blood stem cells respond to perturbations of the "steady state" of blood cell formation? C) Which role do blood stem cells play during hemopoietic development assuming that the establishment of bone marrow hemopoiesis requires the "seeding" of blood stem cells into an appropriate cellular environment? D) What is the role of blood stem cells in hemopoietic regeneration after partial body irradiation with a small volume of marrow (and hence stem cells) protected? and E) What are the mechanisms and/or kinetics of hemopoietic recovery if stem cells introduced into the circulation were collected from exogenous (autologous or allogeneic) sources? In this review presentation, experimental work of our group and of other members of the scientific community is summarized. It becomes obvious that blood stem and progenitor cells play a key role in hematopoietic homeostasis. Furthermore, their physiology and pathophysiology deserve rigorous experimental studies in order to develop a novel tool in the diagnosis and prognosis of neoplastic and non-neoplastic disorders of blood cell formation. Stem Cells 1998;16(suppl1):13-29

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Section: Stem Cell Migration To Reconstitute Hematopoiesissupporting

confidence: 91%

The role of blood stem cells in hematopoietic cell renewal

Fliedner

2009

STEM CELLS

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“…8 Studies in dogs and humans have shown that PBPC recirculation is usually observed after high-dose cyclophosphamide (HDCYC)-induced marrow aplasia. 9,10 Furthermore, it has been demonstrated that hematopoietic support is not necessary after HDCYC. 11 As HDCYC has been reported to be efficient in the treatment of refractory MM, 12 we have used it at the dose of 7 g/m 2 , either alone or followed by hematopoietic growth factors (HGF), for PBPC mobilization in 116 patients planned to receive subsequently autologous PBPC transplantation (ABPCT).…”

Section: Introductionmentioning

confidence: 99%

Factors affecting both peripheral blood progenitor cell mobilization and hematopoietic recovery following autologous blood progenitor cell transplantation in multiple myeloma patients: a monocentric study

et al. 1998

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The aim of the study was to analyze the factors influencing peripheral blood progenitor cell (PBPC) collection after high-dose cyclophosphamide (HDCYC) (7 g/m 2 ) and hematopoietic recovery after autologous transplantation of HDCYC-mobilized PBPC (ABPCT) in 116 patients with aggressive multiple myeloma (MM). Following HDCYC 74 patients received hematopoietic growth factors (HGF), either G-CSF (n = 19) or GM-CSF (n = 55). All the patients were subsequently planned to undergo ABPCT. PBPC collection was possible for 106 patients. The most important prognostic factor for collection of more than 25 × 10 4 CFU-GM cells/kg and 2 × 10 6 CD34 + cells/kg was the use of HGF (P = 0.002 and 0.009, respectively). Previous use of an alkylating agent, response to treatment before HDCYC, and interval between diagnosis and HDCYC were also significant factors (P = 0.004, 0.025 and 0.001, respectively). The number of CFU-GM cells infused was the most important parameter for rapid and complete hematological recovery after ABPCT (P Ͻ 0.0001). Thus the use of HGF post-HDCYC is the major factor which, associated with reduced time between diagnosis and HDCYC and the use of an alkylating agent, could increase the numbers of hematopoietic progenitors collected, and subsequently improve hematopoietic recovery following ABPCT in MM patients.

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“…23,24 (and references therein) Shortly after the CFU-S stem-cell assay became available, 1 a plethora of studies revealed perturbations in the number of circulating stem/progenitor cells (CFUSs) following several empiric treatments (endotoxin, 25,26 proteases, 25,27 vaccines, 28 Epo crude preparations, 29 polymethacrylic acid [PMAA], 25 poly I-C, 29,30 etc). Some of the treatments were interpreted to induce complement activation 31 or to release colony-stimulating factor, 30,32 or were seen as an insult to sinusoidal architecture of BM (ie, endotoxin, enzymes, neutral polysaccharides 25,30,33 ), whereas the mechanisms of other treatments (ie, pertussis vaccine, 28 polyanions, PMAA, 25 or dextran sulfate, 34,35 or after chemotherapy 36,37 ) remained totally obscure. …”

Section: Beyond Bonementioning

confidence: 99%

Stem-cell ecology and stem cells in motion

Papayannopoulou

Scadden

2008

Blood

158

125

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This review highlights major scientific developments over the past 50 years or so in concepts related to stem-cell ecology and to stem cells in motion. Many thorough and eloquent reviews have been presented in the last 5 years updating progress in these issues. Some paradigms have been challenged, others validated, or new ones brought to light. In the present review, we will confine our remarks to the historical development of progress. In doing so, we will refrain from a detailed analysis of controversial data, emphasizing instead widely accepted views and some challenging novel ones. (Blood. 2008;111:3923-3930)

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Cyclophosphamide treatment expands the circulating hematopoietic stem cell pool in dogs.

Cited by 86 publications

References 18 publications

The role of blood stem cells in hematopoietic cell renewal

The role of blood stem cells in hematopoietic cell renewal

Factors affecting both peripheral blood progenitor cell mobilization and hematopoietic recovery following autologous blood progenitor cell transplantation in multiple myeloma patients: a monocentric study

Stem-cell ecology and stem cells in motion

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