Cyclophosphazene-based multi-site coordination ligands

Investigation of nucleophilic substitution pathway for the reactions of 1,4-benzodioxan-6-amine with chlorocyclophosphazenes

“…The crystal packing investigations of compounds 1, 2, and 4, and compounds 7a and 7c showed that there were many intermolecu- Table 3 The selected bond lengths (Å) and angles (°) for cyclotriphosphazene derivatives 1, 2 and 4. 119.00 (12) 119.29 (11) 119.14 (12) 115.43 (11) 115.51(12) N2-P3-N3 118.50 (12) 119.77 (11) 119.93 (12) 120.04 (12) 120.35(12) P1-N1-P2 120.35 (14) 122.32 (12) 123.02 (14) 124.72 (14) 124.83 (14) lar interactions where separation between donor and acceptor atoms was less than 3.2 Å (Table S1 was given in the Supplementary information). The exocyclic NH and dioxan moieties of substituents played an important role in the packing organization, the intermolecular N-HÁ Á ÁO interaction was commonly observed for all compounds apart from the N-HÁ Á ÁN and C-HÁ Á ÁO interactions in compound 4.…”

“…Aminocyclophosphazenes use a variety of applications in science and technology including anti-cancer reagents [1][2][3][4], tumor growth inhibitors [5,6], biologically and biomedically active molecules [7], flame retardants [8], antimicrobial reagents [9], multisite coordination ligands [10][11][12][13] and supramolecular chemistry [14]. Although the reactions of hexachlorocyclotriphosphazatriene (N 3 P 3 Cl 6 , trimer) with primary aliphatic [15,16] and aromatic [8b, [17][18][19] amines have been studied in great detail [20][21][22][23], there are limited studies about the reactions of octachlorocyclotetraphosphazatetraene (N 4 P 4 Cl 8 , tetramer), with a number of especially primary aromatic amines in the literature [13b, 22,[24][25][26][27].…”

The Syntheses and Structural Characterizations, Antimicrobial Activity and in Vitro Dna Binding of 4-Fluorobenzylspiro(n/O)cyclotriphosphazenes and Their Phosphazenium Salts

“…Hexachlorocyclotriphosphazene, N3P3Cl6, is one of the best known and studied one as the starting compound in the family of inorganic heterocyclic ring systems [1]. Various cyclotriphosphazene derivatives have been prepared from the Cl replacement reactions of N3P3Cl6 with the different nucleophiles [2].…”

Chiral configurations in cyclophosphazene chemistry

“…It is possible to use cyclophosphazene rings as scaffolds for the design and construction of a variety of ligands each of which can provide unique steric and electronic environments for transition metal coordination [131][132][133][134][135][136][137][138][139]. The interaction of cyclophosphazene-based multisite coordination ligands with transition metal ions can lead to metal-rich assemblies possessing interesting catalytic or magnetic properties [139].…”