Cyclopia-otocephaly-agnathia-synotia-astomia complex: A case report

Singh, Kanwar; Sharma, Shruti; Agarwal, Khushboo; Kalra, Abhimanyu

doi:10.4103/jcn.jcn_23_18

Cited by 4 publications

(4 citation statements)

References 1 publication

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“…However, various risk factors implicated include genetic factors and chromosomal anomalies (mostly trisomy D), multiple pregnancies (especially twin pregnancy), previous unexplained miscarriages, maternal diabetes, infections during pregnancy (toxoplasmosis, rubella, cytomegalovirus, and herpes simplex virus), exposure to UV light and ionic radiation, smoking, alcohol and certain drugs during pregnancy (such as salicylates, amidopyrine, corticosteroids, aspirin, lithium, anticonvulsants, retinoic acid, anticancer agents, cyclopamine [Veratrum californium, found in corn lily or false hellebore]). 1,3,5,[13][14][15][16][17] However, in the presented case, no risk factors could be identified.…”

Section: Discussionmentioning

confidence: 99%

A rare case report of a cyclopian malformation

Priya

Mukherjee

Singh

2023

Int J Reprod Contracept Obstet Gynecol

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A rare form of median faciocerebral dysplasia, characterized by a single central orbital fossa with a tubular nose-like appendage above the orbit is known as cyclopian malformation/monster. It is the most severe form of alobar holoprosencephaly. Since most of these cases are sporadic, incompatible with life, and due to the limited literature knowledge, the exact etiology of this condition remains undetermined. However, various risk factors implicated include genetic factors and chromosomal anomalies (mostly trisomy D). Here we present a case of stillborn male cyclopian fetus born to a 34 year old 3rd gravida by caesarean section. There was no history of any drugs or alternative medicine intake (except iron-folic acid, calcium, thyroxin), radiation exposure, or a significant family history or consanguinity. Her only 33-week scan (done at a peripheral center) failed to identify any fetal abnormality. This case is reported because cyclopia is a rare/uncommon developmental anomaly especially with the advancement in antenatal ultrasonography to identify malformed fetuses early in pregnancy.

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Section: Discussionmentioning

confidence: 99%

A rare case report of a cyclopian malformation

Priya

Mukherjee

Singh

2023

Int J Reprod Contracept Obstet Gynecol

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“…The exact causes of cyclopia remain unknown [4] . However, researchers believe that several factors can increase the risk of cyclopia.…”

Section: Discussionmentioning

confidence: 99%

“…Another risk factor related to this anomaly is Veratrum californicum , found in corn lily or false hellebore. It is implicated in causing cyclopia (when ingested believing the plant to be hellebore, which can cure the morning sickness symptoms associated with the first few months of pregnancy) [4] , [5] .…”

Section: Discussionmentioning

confidence: 99%

“…In this health condition, the eye's orbits are not properly divided into two cavities so that they can be seen either as a single eye field or two bilateral fields that are very close to each other [3] . This congenital disorder affects both animals and humans [4] . Patients with cyclopia syndrome typically have a missing or dysfunctional nose with a long snout.…”

Section: Introductionmentioning

confidence: 99%

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Cyclopia, a newborn with a single eye, a rare but lethal congenital anomaly: A case report

Faraji

Hassanpour

Goli

et al. 2021

International Journal of Surgery Case Reports

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Cyclopia Associated with Microcephaly, Hydrocephaly and Clubfoot: A Case Report from Burkina Faso, West Africa

Dieudonne,

Sibraogo,

Solo

et al. 2024

JGO

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Cyclopia is the most severe form of alobar holoprosencephaly, characterized by the fusion of the two orbits into one. It is a genetic disease incompatible with life. It is most often associated with other craniofacial malformations such as microcephaly, cleft lip and palate, nasal agenesis and facial dysmorphia. The incidence of cyclopia varies from 1/13,000 to 1/20,000 births, and the etiology of this malformation has yet to be elucidated. These include genetic factors, multiparity, female gender, unexplained miscarriage, gestational diabetes, infections during pregnancy, UV radiation, smoking and alcohol consumption. It is probably less diagnosed in developing countries, where pregnancies are not normally monitored, and antenatal ultrasound is less common. We report the case of a 22-year-old pregnant woman, third gesture and two pares with two live children. She came on her own for a third-trimester ultrasound. She had a spontaneous pregnancy. She reported no previous history of a spontaneous pregnancy. Morphological ultrasound revealed cyclopia associated with microcephaly and hydrocephaly. We obtained informed consent from the couple. The patient exploded with a female fetus weighing 700 g, her cranial perimeter at 18 cm and thoracic perimeter at 34 cm. A clubfoot was noted on expulsion of the fetus, which is a particular feature of our case.

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Cyclopia-otocephaly-agnathia-synotia-astomia complex: A case report

Cited by 4 publications

References 1 publication

A rare case report of a cyclopian malformation

A rare case report of a cyclopian malformation

Cyclopia, a newborn with a single eye, a rare but lethal congenital anomaly: A case report

Cyclopia Associated with Microcephaly, Hydrocephaly and Clubfoot: A Case Report from Burkina Faso, West Africa

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