Cyclopia syndrome

Cyclopia with proboscis: A rare congenital anomaly

“…4 Genes affecting chromosomes 3 and 10, maternal exposure to teratogenic drugs (such as salicylates, amidopyrine, corticosteroids, aspirin, lithium, anticonvulsants, retinoic acid, anticancer agents), alcohol, toxoplasmosis, rubella, cytomegalovirus, and herpes simplex (TORCH) infections, ionic radiation, and maternal diabetes are the notable risk factors in previously reported cases. 4,[12][13][14] As already mentioned, finding an etiologic relation is very difficult in such conditions, mainly due to the limited literature knowledge and our inability to reach the patient's previous laboratory and medical reports, and lack of other aforementioned risk factors, and the regular consumption of alcohol might the associated factor for the fetal anomaly in our case.…”

Cyclopia, a newborn with a single eye, a rare but lethal congenital anomaly: A case report

“…Cyclopia often leads to a stillbirth since the brain and other parts of the body do not grow normally in fetuses with this disorder. The brain of a neonate with cyclopia cannot manage the formation of the other organs that are necessary for survival [13] . In 2015, the live birth of a newborn with cyclopia was reported in Jordan.…”

Symmetry Transformations in Metazoan Evolution and Development

“…The Shh gene is involved in the separation of the single eye field into two bilateral fields. If the expression of the Shh gene is lost or inhibited, the result may be cyclopia (a single eye in the center of the face) and other ocular malformations in vertebrates, including humans [33,103,104,[106][107][108]. Such malformations as holoprosencephaly and cyclopia reveal a morphological midline seam between left and right sides, demonstrating these disorders of the midline [103][104][105]107,108].…”