Cyclosporin in Behçet's Disease

mentioning

confidence: 99%

Cyclosporin‐Induced Gingival Overgrowth at the Newly Formed Edentulous Ridge in Rats: A Morphological and Histometric Evaluation

Hsieh

Shen

et al. 2001

“…5 Cyclosporin A (CsA), an immunosuppressant agent, is widely used not only in transplantation but also in the treatment of immune diseases. 6,7 The side effects of CsA, such as nephrotoxicity and hepatoxicity, as well as gingival alteration, have been noticed since the initial clinical evaluation of the drug. 6,8 Recently, the role of NO in CsA-induced nephrotoxicity has been investigated.…”

mentioning

confidence: 99%

Ameliorated Effect of L‐Arginine Supplementation on Gingival Morphology in Cyclosporin‐Treated Rats

Chou

Liu

et al. 2000

Gingival morphology in CsA-fed rats was evaluated after NO substrate (L-arginine) and blockade (L-NAME) treatment for 4 weeks. Significantly decreased dimensions were noted in the L-arginine group compared to the CsA group at weeks 2 and 4. Although an inhibitory effect on the gingival morphology was also observed in the L-NAME group, another unknown mechanism might be involved. Within the limitations of the study, we suggest that NO may have an important role in the mechanism of CsA-induced gingival overgrowth.

“…[3][4] The incidence of gingival overgrowth in CSA-treated patients has been reported to vary between 10 and 70%. '5-9 The possible efficacy of CSA is also being evaluated in other diseases, such as Type 1 diabetes mellitus,10 " Bechet's disease, 12 psoriasis,13'14 and other skin disorders. '5-18 This increasing spectrum of indications is expected to significantly increase CSA use, and thus, a concomitant increase in prevalence of its side effects should be expected.…”

mentioning

confidence: 99%

Dose‐Dependent Gingival Overgrowth Induced by Cyclosporin in Rats

Nieh²,

Chang

et al. 1995

This study evaluated the effect of dosage on severity of cyclosporin-A (CSA) induced gingival overgrowth. Eighty (80) male Sprague-Dawley rats were randomly distributed into 4 groups. Rats in each group daily received CSA in mineral oil by gastric feeding at dosages of 0 (control), 3, 10, and 30 mg/kg, respectively, for 6 weeks. Stone models of the mandibular incisal region were obtained biweekly and were used for analysis of the gingival dimensions. Animals were sacrificed at the end of week 6 and tissue sections were processed for histopathologic evaluations. Animals were sacrificed at the end of week 6 and tissue sections were processed for histopathologic evaluation Gingival overgrowth including bucco-lingual and mesio-distal width and vertical height were significantly increased with increasing CSA dosage. Furthermore, the gingival dimensions displayed a positive linear relation to dosage and treatment duration. The histopathologic evaluation revealed a granulomatous tissue wedging the tooth-gingival interface in the 3 mg/kg group. This tissue had reached exuberant size in the 10 and 30 mg/kg groups. In summary, the analysis of gingival dimensions the histopathologic evaluation shows a dose-dependent effect on the severity of CSA-induced gingival overgrowth.