Cyclosporine-related neurotoxicity in a patient after bilateral lung transplantation for cystic fibrosis

Posterior Reversible Encephalopathy Syndrome after Solid Organ Transplantation

“…[3][4][5][6][9][10][11][12][13][14][15][16][17]19,[22][23][24][25][26][27]32 Severe infection, sepsis, and shock may also represent important associations. 18 Although blood levels of cyclosporine and tacrolimus tend not to correlate with PRES, medication withdrawal often results in alleviation of toxicity.…”

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] PRES is also seen in association with infection, sepsis, shock, autoimmune disease, and after chemotherapy. [18][19][20][21][22][23][24][25][26][27] Patients develop headache, visual disturbance, or altered mentation, which often progress to seizure.…”

The investigation of correlation between Iminoral concentration and neurotoxic levels after kidney transplantation

“…Previous publication reported that combination of cyclosporine with high doses of methylprednisolone, in a 33-year-old male with cystic fibrosis, caused severe neurotoxic signs tended to coma. [ 19 ] Out of 75 kidney transplant recipients, tremor, headache and anxiety were identified in 47%, 68% and 45%. This is in agreement with previous publication in which it was reported that calcineurin inhibitors may cause mild symptoms, such as tremors and paresthesia, or severe symptoms, such as disabling pain syndrome and leukoencephalopathy.…”

“…This is in agreement with previous publication in which it was reported that calcineurin inhibitors may cause mild symptoms, such as tremors and paresthesia, or severe symptoms, such as disabling pain syndrome and leukoencephalopathy. [ 14 19 20 21 22 ] ABCB1 polymorphisms may be supportive in estimating convinced cyclosporine-linked adverse effects in renal transplant recipients. [ 23 ] Cyclosporine is metabolized by intestinal and hepatic CYP3A4/3A5 and transported across the cell membrane by P-glycoprotein.…”